| Long name: |
HES3 Primary Polyclonal Antibody |
| Also known as: |
HES3 PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
HES3 |
| Specificity: |
This is a highly specific antibody against HES3 |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Subcellular location: |
Nucleus |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human HES3 |
| Gene ID number: |
390992 |
| Tested Applications: |
IF(IHC-P), IHC-P |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
HES1 and HES2 are expressed in a variety of adult and embryonic tissues, HES1-6, HES2 binds to both N and E box sites, HES3 is expressed exclusively in cerebellar Purkinje cells, HES6 inhibits HES1 activity, HES6 is produced in brain as well as in the limb buds of developing embryos, Most HES family members, Rather, The HES family members form a complex with TLE, The HES/TLE complex functions by directly binding to DNA, The mammalian homologues of Drosophila hairy and Enhancer of split are the HES gene family members, and HES5 is found solely in the nervous system, and this interaction is mediated by the carboxy terminal WRPW motif of the HES proteins, including HES1 and HES5, instead of interfering with activator proteins, preferentially bind to the N box (CACNAG) as opposed to the E box (CANNTG), the mammalian homologue of Groucho, thereby promoting transcription, which also encode bHLH transcriptional repressors that regulate myogenesis and neurogenesis, while HES6 does not bind DNA, The Drosophila hairy and Enhancer of split genes encode basic helix-loop-helix (bHLH) transcriptional repressors that function in the Notch signaling pathway and control segmentation and neural development during embryogenesis |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
Class B basic helix loop helix protein 43, Hairy and enhancer of split 3, Transcription factor HES 3, bHLHb43 |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
HES3 |
| Short name: |
HES3 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
HES3 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
26226 |
| Gene: |
HES3 |
More about : HES3 |
| Long gene name: |
hes family bHLH transcription factor 3 |
| Synonyms gene name: |
hairy and enhancer of split 3 (Drosophila) |
| Synonyms: |
bHLHb43 |
| Locus: |
1p36, 31 |
| Discovery year: |
2005-05-17 |
| Entrez gene record: |
390992 |
| RefSeq identity: |
NM_001024598 |
| Classification: |
Basic helix-loop-helix proteins |
| Havana BLAST/BLAT: |
OTTHUMG00000001271 |