| Long name: |
FITC Conjugated, RASSF1 Polyclonal Antibody |
| Category: |
Conjugated Primary Antibodies |
| Conjugation: |
Anti-FITC Antibody |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
RASSF1 |
| Specificity: |
This is a highly specific antibody against RASSF1 |
| Modification: |
Unmodified |
| Modification site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen_range: |
150-195/340 |
| Subcellular location: |
Nucleus, Cytoplasm |
| Source: |
KLH conjugated synthetic peptide derived from human RASSF1 |
| Gene ID number: |
11186 |
| Swiss Prot: |
Q9NS23 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Crossreactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Antigen background: |
APC, DAXX and USP7, Inhibits proliferation by negatively regulating cell cycle progression at the level of G1/S-phase transition by regulating accumulation of cyclin D1 protein, Isoform A disrupts interactions among MDM2, Isoform A interacts with CDC2, Isoform C has been shown not to perform these roles, Mediates activation of STK3/MST2 and STK4/MST1 during Fas-induced apoptosis by preventing their dephosphorylation, Required for death receptor-dependent apoptosis, When associated with MOAP1, an activator of the anaphase-promoting complex, no function has been identified for this isoform, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF1 stimulation, resulting in the inhibition of APC activity and mitotic progression, thus contributing to the efficient activation of TP53 by promoting MDM2 self-ubiquitination in cell-cycle checkpoint control in response to DNA damage, Potential tumor suppressor |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA |
| Excitation Emission: |
494nm/518nm |
| Synonyms: |
NORE2A REH3P21 RDA32 123F2 |
| Properties: |
Bioss Primary Conjugated Antibodies FITC is highly sensitive to pH extremes, FITC has a green emission that's usually collected at 530 nanometers, FITC has a high quantum yield (efficiency of energy transfer from absorption to emission fluorescence) and approximately half of the absorbed photons are emitted as fluorescent light, For fluorescent microscopy applications, This Bioss Primary Conjugated Antibodies Fluorescein isothiocyanate (FITC) antibody is currently after some BD antibodies the most commonly used fluorescent dye for FACS, When excited at 488 nanometers, its photo bleaching effects are not observed due to a very brief interaction at the laser intercept, the 1 FITC is seldom used as it photo bleaches rather quickly though in flow cytometry applications, the FL1 detector of a FACSCalibur or FACScan, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
RASSF1 Conjugated |
| Short name: |
FITC Conjugated, RASSF1 Antibody |
| Technique: |
Fluorescein, antibodies against human proteins, antibodies for, antibody Conjugates, Antibody |
| Label: |
FITC |
| Alternative name: |
fluorecein coupled, RASSF1 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
9882 |
| Gene: |
RASSF1 |
More about : RASSF1 |
| Long gene name: |
Ras association domain family member 1 |
| Synonyms gene name: |
Ras association (RalGDS/AF-6) domain family member 1 |
| Locus: |
3p21, 31 |
| Discovery year: |
2000-05-30 |
| GenBank acession: |
AF132675 |
| Entrez gene record: |
11186 |
| Classification: |
Ras association domain family |
| Havana BLAST/BLAT: |
OTTHUMG00000149958 |