| Long name: |
CXCR2 (Ser347) Primary Polyclonal Antibody |
| Also known as: |
CXCR2 (Ser347) PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
CXCR2 Ser347 |
| Specificity: |
This is a highly specific antibody against CXCR2 Ser347 |
| Modification(s): |
Phosphorylation |
| Modification site(s): |
Ser347 |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
KLH conjugated synthetic phosphopeptide derived from human CXCR2 around the phosphorylation site of Ser347 |
| Gene ID number: |
3579 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Alternatively spliced variants, IL8RA, It binds to IL8 with high affinity, Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration, Nov 2009], The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor, This gene, This protein is a receptor for interleukin 8 (IL8), This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), This receptor mediates neutrophil migration to sites of inflammation, [provided by RefSeq, a gene encoding another high affinity IL8 receptor, a protein with melanoma growth stimulating activity, a pseudogene of IL8RB, and has been shown to be a major component required for serum-dependent melanoma cell growth, and transduces the signal through a G-protein activated second messenger system, as well as IL8RBP, encoding the same protein, form a gene cluster in a region mapped to chromosome 2q33-q36, have been identified, The protein encoded by this gene is a member of the G-protein-coupled receptor family |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
C-X-C chemokine receptor type 2, CD 182, CD182, CD182 antigen, CDw128b, CMKAR2, CXC R2, CXC-R2, CXC-chemokine receptor 2, CXCR 2, CXCR-2, CXCR2 phospho Ser347, CXCR2_HUMAN, Chemokine CXC receptor 2, GRO/MGSA receptor, High affinity interleukin-8 receptor B, IL-8 receptor type 2, IL-8R B, p-CD182 phospho Ser347, p-CXCR2 phospho S347, CXCR2 phospho S347 |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
CXCR2 (Ser347) |
| Short name: |
CXCR2 (Ser347) Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
chemokine (C-X-C motif) receptor 2 (Ser347) (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
CD182 and CDw128b and CMKAR2 and IL8R2 and IL8RA and IL8RB, CXCR2 and IDBG-80804 and ENSG00000180871 and 3579, Cell surfaces, Cxcr2 and IDBG-166395 and ENSMUSG00000026180 and 12765, interleukin-8 binding, this GO :0002407 and dendritic cell chemotaxis and biological process this GO :0004871 and signal transducer activity and molecular function this GO :0004918 and interleukin-8 receptor activity and molecular function this GO :0004930 and G-protein coupled receptor activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005622 and intracellular and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0005887 and integral component of plasma membrane and cellular component this GO :0006935 and chemotaxis and biological process this GO :0006954 and inflammatory response and biological process this GO :0006968 and cellular defense response and biological process this GO :0007165 and signal transduction and biological process this GO :0007166 and cell surface receptor signaling pathway and biological process this GO :0007186 and G-protein coupled receptor signaling pathway and biological process this GO :0007200 and phospholipase C-activating G-protein coupled receptor signaling pathway and biological process this GO :0008284 and positive regulation of cell proliferation and biological process this GO :0009986 and cell surface and cellular component this GO :0016020 and membrane and cellular component this GO :0016021 and integral component of membrane and cellular component this GO :0016494 and C-X-C chemokine receptor activity and molecular function this GO :0019959 and interleukin-8 binding and molecular function this GO :0030593 and neutrophil chemotaxis and biological process this GO :0031623 and receptor internalization and biological process this GO :0038112 and interleukin-8-mediated signaling pathway and biological process this GO :0042119 and neutrophil activation and biological process this GO :0042629 and mast cell granule and cellular component this GO :0045087 and innate immune response and biological process this GO :0070098 and chemokine-mediated signaling pathway and biological process, this GO :0004871 : signal transducer activity, this GO :0004871 : signal transducer activity and also this GO :0004918 : interleukin-8 receptor activity and also this GO :0004930 : G-protein coupled receptor activity and also this GO :0005515 : protein binding and also this GO :0016494 : C-X-C chemokine receptor activity and also this GO :0019959 : interleukin-8 binding, this GO :0004918 : interleukin-8 receptor activity, this GO :0004930 : G-protein coupled receptor activity, this GO :0005515 : protein binding, this GO :0016494 : C-X-C chemokine receptor activity, this GO :0019959 : interleukin-8 binding, chemokine (C-X-C motif) receptor 2 |
| Identity: |
6027 |
| Gene: |
CXCR2 |
More about : CXCR2 |
| Long gene name: |
C-X-C motif chemokine receptor 2 |
| Synonyms gene: |
IL8RB |
| Synonyms gene name: |
beta chemokine (C-X-C motif) receptor 2 , interleukin 8 receptor |
| Synonyms: |
CMKAR2 CD182 |
| Locus: |
2q35 |
| Discovery year: |
1991-08-19 |
| GenBank acession: |
U11869 |
| Entrez gene record: |
3579 |
| Pubmed identfication: |
1427896 |
| RefSeq identity: |
NM_001557 |
| Classification: |
CD molecules C-X-C motif chemokine receptors Interleukin receptors |
| Havana BLAST/BLAT: |
OTTHUMG00000133107 |