| Long name: |
CYB5R3 Primary Polyclonal Antibody |
| Also known as: |
CYB5R3 PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
CYB5R3 |
| Specificity: |
This is a highly specific antibody against CYB5R3 |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human CYB5R3 |
| Gene ID number: |
1727 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
A serine residue at position 117 seems to only be found in persons of African origin, Asians, CYB5R3 belongs to the flavoprotein pyridine nucleotide cytochrome reductase family and has two naturally occuring isoforms, CYB5R3 is involved in the desaturation and elongation of fatty acids, Defects in CYB5R3 are the cause of hereditary methemoglobinemia (HM), Indo-Aryans or Arabs, Isoform 1 is anchored to the cytoplasmic side of the endoplasmic reticulum membrane and mitochondrion outer membrane, It is not found in Caucasians, The allele frequency is 0, There are three forms of this disease: type 1 (HM1), This difference seems to have no effect on the enzyme activity, Type 2 is a severe form accompanied by mental retardation and neurological impairment, and type 3 (HM3), cholesterol biosynthesis, drug metabolism and, in erythrocytes, in which the enzyme is completely deficient, in which the enzyme is only deficient in erythrocytes with a mild cyanosis, methemoglobin reduction, type 2 (HM2), where the deficiency is seen in all blood cells, while isoform 2 is the soluble form found in erythrocytes, 23 in African Americans, CYB5R3 is a 301 amino acid protein encoded by the human gene CYB5R3 |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
Cyb5r3, Cytochrome b5 reductase, Cytochrome b5 reductase 3, DIA1, Diaphorase 1, Diaphorase-1, NADH cytochrome b5 reductase 3, NADH-cytochrome b5 reductase 3 membrane-bound form, NADH-cytochrome b5 reductase 3 soluble form, NB5R3_HUMAN, OTTHUMP00000028761, OTTHUMP00000198435, OTTHUMP00000198574, OTTHUMP00000198662, OTTHUMP00000198665, B5R |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
CYB5R3 |
| Short name: |
CYB5R3 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
CYB5R3 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
2873 |
| Gene: |
CYB5R3 |
More about : CYB5R3 |
| Long gene name: |
cytochrome b5 reductase 3 |
| Synonyms gene: |
DIA1 |
| Synonyms gene name: |
diaphorase (NADH) (cytochrome b-5 reductase) |
| Synonyms name: |
NADH-cytochrome b5 reductase 3 |
| Locus: |
22q13, 2 |
| Discovery year: |
2001-06-22 |
| GenBank acession: |
M16461 |
| Entrez gene record: |
1727 |
| Pubmed identfication: |
2479590 3268037 |
| Havana BLAST/BLAT: |
OTTHUMG00000150745 |