| Long name: |
ALEXA FLUOR 647 Conjugated, HDAC4 + 5 + 9 Polyclonal Antibody |
| Also known as: |
Anti-HDAC4 + 5 + 9 PAb ALEXA FLUOR 647 |
| Category: |
Conjugated Primary Antibodies |
| Conjugated with: |
647, ALEXA FLUOR® |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
HDAC4 + 5 + 9 |
| Specificity: |
This is a highly specific antibody against HDAC4 + 5 + 9 |
| Modification: |
Unmodified |
| Modification Site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human HDAC4 + 5 + 9 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Cross-reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the antigen: |
Acetylation of lysine residues in the amino terminal tail domain of histone results in an allosteric change in the nucleosomal conformation and an increased accessibility to transcription factors by DNA, Conversely, DNA closely associates with histones and other nuclear proteins to form chromatin, HAT1, HDAC2 (also designated RPD3) and HDAC3-7, Mammalian HDAC1 (also designated HD1), Mammalian HDAC7 interacts with the adaptor mSin3A, PCAF (p300/CBP-associated factor), Several mammalian proteins have been identified as nuclear histone acetylases, The interaction of HDAC7 with mSin3A suggests the association of multiple repression complexes of transcription factors, The remodeling of chromatin is believed to be a critical component of transcriptional regulation and a major source of this remodeling is brought about by the acetylation of nucleosomal histones, and the TFIID subunit TAF II p250, have been identified as histone deacetylases, including GCN5, p300/CBP, the deacetylation of histones is associated with transcriptional silencing, In the intact cell |
| Purification: |
Purified by Protein A |
| Storage conditions: |
50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA |
| Excitation emission: |
650nm/665nm |
| Synonyms: |
KIAA0288 HDAC-A HDACA HD4 HA6116 HDAC-4 |
| Properties: |
ALEXA FLUOR made this Alexa Fluor 633 conjugate that can be used in multi-color flow cytometry with instruments equipped with a second red laser or red diode, ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 633 is a practical alternative to APC as well as Cy5, Bioss Primary Conjugated Antibodies, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, It is detected in the FL4 detector of the core's upgraded 2-laser FACScans, Like other Alexa Fluor dyes, exhibits uncommon photo stability, making it an ideal choice for fluorescent microscopy, the HDAC4 + 5 + 9 Antibody, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
ALEXA FLUOR 647, Alexa Fluor |
| Gene target: |
HDAC4 + 5 + 9 |
| Short name: |
HDAC4 + 5 + 9 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Label: |
ALEXA FLUOR 647 |
| Alternative name: |
ALEXA FLUOR 647, histone deacetylase 4 and 5 and 9 (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
AHO3 and BDMR and HA6116 and HD4 and HDAC-4 and HDAC-A and HDACA, DNA-templated and biological process this GO :0006954 and inflammatory response and biological process this GO :0007399 and nervous system development and biological process this GO :0008134 and transcription factor binding and molecular function this GO :0008270 and zinc ion binding and molecular function this GO :0008284 and positive regulation of cell proliferation and biological process this GO :0008285 and negative regulation of cell proliferation and biological process this GO :0010832 and negative regulation of myotube differentiation and biological process this GO :0010882 and regulation of cardiac muscle contraction by calcium ion signaling and biological process this GO :0014894 and response to denervation involved in regulation of muscle adaptation and biological process this GO :0014898 and cardiac muscle hypertrophy in response to stress and biological process this GO :0016568 and chromatin modification and biological process this GO :0016575 and histone deacetylation and biological process this GO :0017053 and transcriptional repressor complex and cellular component this GO :0019901 and protein kinase binding and molecular function this GO :0030017 and sarcomere and cellular component this GO :0030018 and Z disc and cellular component this GO :0030183 and B cell differentiation and biological process this GO :0030955 and potassium ion binding and molecular function this GO :0031594 and neuromuscular junction and cellular component this GO :0031672 and A band and cellular component this GO :0032041 and NAD-dependent histone deacetylase activity (H3-K14 specific) and molecular function this GO :0033235 and positive regulation of protein sumoylation and biological process this GO :0033558 and protein deacetylase activity and molecular function this GO :0033613 and activating transcription factor binding and molecular function this GO :0034983 and peptidyl-lysine deacetylation and biological process this GO :0042113 and B cell activation and biological process this GO :0042493 and response to drug and biological process this GO :0042641 and actomyosin and cellular component this GO :0042826 and histone deacetylase binding and molecular function this GO :0043234 and protein complex and cellular component this GO :0043393 and regulation of protein binding and biological process this GO :0043433 and negative regulation of sequence-specific DNA binding transcription factor activity and biological process this GO :0043565 and sequence-specific DNA binding and molecular function this GO :0044212 and transcription regulatory region DNA binding and molecular function this GO :0045668 and negative regulation of osteoblast differentiation and biological process this GO :0045820 and negative regulation of glycolytic process and biological process this GO :0045892 and negative regulation of transcription, DNA-templated and biological process this GO :0045893 and positive regulation of transcription, DNA-templated and biological process this GO :0045944 and positive regulation of transcription from RNA polymerase II promoter and biological process this GO :0046969 and NAD-dependent histone deacetylase activity (H3-K9 specific) and molecular function this GO :0046970 and NAD-dependent histone deacetylase activity (H4-K16 specific) and molecular function this GO :0048742 and regulation of skeletal muscle fiber development and biological process this GO :0051091 and positive regulation of sequence-specific DNA binding transcription factor activity and biological process this GO :0051153 and regulation of striated muscle cell differentiation and biological process this GO :0070491 and repressing transcription factor binding and molecular function this GO :0070555 and response to interleukin-1 and biological process this GO :0070932 and histone H3 deacetylation and biological process this GO :0070933 and histone H4 deacetylation and biological process this GO :0097372 and NAD-dependent histone deacetylase activity (H3-K18 specific) and molecular function, HDAC4 and IDBG-642244 and ENSBTAG00000017764 and 517559, HDAC4 and IDBG-84594 and ENSG00000068024 and 9759, Hdac4 and IDBG-181579 and ENSMUSG00000026313 and 208727, NAD-dependent histone deacetylase activity (H3-K18 specific), nuclei, this GO :0000118 and histone deacetylase complex and cellular component this GO :0000122 and negative regulation of transcription from RNA polymerase II promoter and biological process this GO :0001047 and core promoter binding and molecular function this GO :0001501 and skeletal system development and biological process this GO :0002076 and osteoblast development and biological process this GO :0003677 and DNA binding and molecular function this GO :0003714 and transcription corepressor activity and molecular function this GO :0004407 and histone deacetylase activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005829 and cytosol and cellular component this GO :0006338 and chromatin remodeling and biological process this GO :0006351 and transcription, this GO :0001047 : core promoter binding, this GO :0001047 : core promoter binding and also this GO :0003677 : DNA binding and also this GO :0003714 : transcription corepressor activity and also this GO :0004407 : histone deacetylase activity and also this GO :0005515 : protein binding and also this GO :0008134 : transcription factor binding and also this GO :0008270 : zinc ion binding and also this GO :0019901 : protein kinase binding and also this GO :0030955 : potassium ion binding and also this GO :0032041 : NAD-dependent histone deacetylase activity (H3-K14 specific) and also this GO :0033558 : protein deacetylase activity and also this GO :0033613 : activating transcription factor binding and also this GO :0042826 : histone deacetylase binding and also this GO :0043565 : sequence-specific DNA binding and also this GO :0044212 : transcription regulatory region DNA binding and also this GO :0046969 : NAD-dependent histone deacetylase activity (H3-K9 specific) and also this GO :0046970 : NAD-dependent histone deacetylase activity (H4-K16 specific) and also this GO :0070491 : repressing transcription factor binding and also this GO :0097372 : NAD-dependent histone deacetylase activity (H3-K18 specific), this GO :0003677 : DNA binding, this GO :0003714 : transcription corepressor activity, this GO :0004407 : histone deacetylase activity, this GO :0005515 : protein binding, this GO :0008134 : transcription factor binding, this GO :0008270 : zinc ion binding, this GO :0019901 : protein kinase binding, this GO :0030955 : potassium ion binding, this GO :0032041 : NAD-dependent histone deacetylase activity (H3-K14 specific), this GO :0033558 : protein deacetylase activity, this GO :0033613 : activating transcription factor binding, this GO :0042826 : histone deacetylase binding, this GO :0043565 : sequence-specific DNA binding, this GO :0044212 : transcription regulatory region DNA binding, this GO :0046969 : NAD-dependent histone deacetylase activity (H3-K9 specific), this GO :0046970 : NAD-dependent histone deacetylase activity (H4-K16 specific), this GO :0070491 : repressing transcription factor binding, this GO :0097372 : NAD-dependent histone deacetylase activity (H3-K18 specific), histone deacetylase 4 |
| Identity: |
14063 |
| Gene: |
HDAC4 |
More about : HDAC4 |
| Long gene name: |
histone deacetylase 4 |
| Synonyms gene: |
BDMR |
| Synonyms gene name: |
brachydactyly-mental retardation syndrome |
| Locus: |
2q37, 3 |
| Discovery year: |
2000-11-28 |
| GenBank acession: |
AB006626 |
| Entrez gene record: |
9759 |
| Pubmed identfication: |
10206986 10220385 20691407 |
| RefSeq identity: |
NM_006037 |
| Classification: |
Histone deacetylases, class IIA |
| Havana BLAST/BLAT: |
OTTHUMG00000133344 |