| Long name: |
OTX1 + OTX2 Primary Polyclonal Antibody |
| Also known as: |
OTX1 + OTX2 PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
OTX1 + OTX2 |
| Specificity: |
This has 79% sequence similarty with CRX, which is specific to Retinal tissue, This is a highly specific antibody against OTX1 + OTX2 |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
30-80/354 |
| Subcellular location: |
Nucleus |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human OTX1 + OTX2 |
| Gene ID number: |
5013, 5015 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
A molecular mechanism depending on a precise threshold of OTX proteins is necessary for the correct positioning of the isthmic region and for anterior brain patterning, OTX1 and OTX2, OTX1 and OTX2 play an important role during early and later events required for proper brain development in that they are involved in the processes of induction, OTX1 is involved in corticogenesis, OTX2 is also required in the early specification of the neuroectoderm, The genes which encode OTX1 and OTX2 map to human chromosomes 2p13 and 14q21-q22, and both OTX1 and OTX2 co-operate in patterning the developing brain through a dosage-dependent mechanism, are two murine homologs of the Drosophila orthodenticle (OTD), for the correct anterior neural plate specification and organization of the primitive streak, respectively, sensory organ development and pituitary functions, show a limited amino acid sequence divergence, specification and regionalization of the brain, which is destined to become the fore-midbrain, while OTX2 is necessary earlier in development, Transcription factors |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
Homeobox protein OTX 1, Homeobox protein OTX1, Homeobox protein OTX2, MCOPS 5, MCOPS5, MGC15736, MGC45000, OTX1_HUMAN, OTX2_HUMAN, Orthodenticle 1, Orthodenticle 2, Orthodenticle homeobox 1, Orthodenticle homeobox 2, Orthodenticle homolog 1, Orthodenticle homolog 2, Orthodenticle homolog 2 Drosophila, Orthodenticle1, Orthodenticle2, Otx 1, Otx 2, otx1, otx2, FLJ38361 |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
OTX1 + OTX2 |
| Short name: |
OTX1 + OTX2 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
OTX1 and OTX2 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
8522 |
| Gene: |
OTX2 |
More about : OTX2 |
| Long gene name: |
orthodenticle homeobox 2 |
| Synonyms gene name: |
orthodenticle homolog 2 (Drosophila) |
| Locus: |
14q22, 3 |
| Discovery year: |
1994-02-08 |
| GenBank acession: |
AF298117 |
| Entrez gene record: |
5015 |
| Pubmed identfication: |
7959790 |
| RefSeq identity: |
, NM_021728 |
| Classification: |
PRD class homeoboxes and pseudogenes |
| Havana BLAST/BLAT: |
OTTHUMG00000152338 |
| Locus Specific Databases: |
LOVD LRG_718 |