| Long name: |
Biotin Conjugated, TRAF3 Polyclonal Antibody |
| Category: |
Conjugated Primary Antibodies |
| Conjugation: |
Biotinylated |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
TRAF3 |
| Specificity: |
This is a highly specific antibody against TRAF3 |
| Modification: |
Unmodified |
| Modification site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen_range: |
130-180/568 |
| Subcellular location: |
Cytoplasm |
| Source: |
KLH conjugated synthetic peptide derived from human TRAF3 |
| Gene ID number: |
7187 |
| Swiss Prot: |
Q13114 |
| Tested applications: |
IHC-P, WB |
| Recommended dilutions: |
IHC-P(1:100-500), WB(1:100-1000) |
| Crossreactivity: |
Mouse, Rat, Human |
| Crossreactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Antigen background: |
Down-regulates proteolytic processing of NFKB2, Inhibits TRAF2-mediated activation of NF-kappa-B, Inhibits activation of NF-kappa-B in response to LTBR stimulation, Is an essential constituent of several E3 ubiquitin-protein ligase complexes, May have E3 ubiquitin-protein ligase activity and promote 'Lys-63'-linked ubiquitination of target proteins, Part of signaling pathways leading to the production of cytokines and interferon, Plays a role T-cell dependent immune responses, Plays a role in the regulation of antiviral responses, Promotes ubiquitination and proteasomal degradation of MAP3K14, Required for normal antibody isotype switching from IgM to IgG, and plays a central role in the regulation of B-cell survival, and thereby inhibits non-canonical activation of NF-kappa-B, Regulates pathways leading to the activation of NF-kappa-B and MAP kinases |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA |
| Synonyms: |
CAP-1 CD40bp CRAF1 LAP1 |
| Properties: |
Avidin and Streptavidin bind to the small biotin and are couple to HRP or AP for ELISA, Biotin conjugates can be detected by horseradish peroxidase, To break the streptavidin Biotin bond we suggest to use a 6 molar guanidine HCl solution with acidity of pH 1, alkaline phosphatase substrates or anti biotin conjugated antibodies, 6, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
TRAF3 Conjugated |
| Short name: |
Conjugated, TRAF3 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, antibody Conjugates, Antibody |
| Label: |
Biotin |
| Alternative name: |
biotinilated coupled, tumor necrosis factor receptor-associated factor 3 (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
CAP-1 and CAP1 and CD40bp and CRAF1 and IIAE5 and LAP1, Plasma membranes, TRAF3 and IDBG-21240 and ENSG00000131323 and 7187, TRAF3 and IDBG-635183 and ENSBTAG00000013475 and 506182, Traf3 and IDBG-172558 and ENSMUSG00000021277 and 22031, thioesterase binding, this GO :0001817 and regulation of cytokine production and biological process this GO :0002224 and toll-like receptor signaling pathway and biological process this GO :0002756 and MyD88-independent toll-like receptor signaling pathway and biological process this GO :0004842 and ubiquitin-protein transferase activity and molecular function this GO :0004871 and signal transducer activity and molecular function this GO :0005164 and tumor necrosis factor receptor binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005739 and mitochondrion and cellular component this GO :0005768 and endosome and cellular component this GO :0005829 and cytosol and cellular component this GO :0006915 and apoptotic process and biological process this GO :0007165 and signal transduction and biological process this GO :0008063 and Toll signaling pathway and biological process this GO :0008270 and zinc ion binding and molecular function this GO :0009898 and cytoplasmic side of plasma membrane and cellular component this GO :0016567 and protein ubiquitination and biological process this GO :0016874 and ligase activity and molecular function this GO :0019901 and protein kinase binding and molecular function this GO :0030162 and regulation of proteolysis and biological process this GO :0031625 and ubiquitin protein ligase binding and molecular function this GO :0031996 and thioesterase binding and molecular function this GO :0032088 and negative regulation of NF-kappaB transcription factor activity and biological process this GO :0032480 and negative regulation of type I interferon production and biological process this GO :0032648 and regulation of interferon-beta production and biological process this GO :0033209 and tumor necrosis factor-mediated signaling pathway and biological process this GO :0034138 and toll-like receptor 3 signaling pathway and biological process this GO :0034142 and toll-like receptor 4 signaling pathway and biological process this GO :0035631 and CD40 receptor complex and cellular component this GO :0035666 and TRIF-dependent toll-like receptor signaling pathway and biological process this GO :0042981 and regulation of apoptotic process and biological process this GO :0045087 and innate immune response and biological process this GO :0050688 and regulation of defense response to virus and biological process, this GO :0004842 : ubiquitin-protein transferase activity, this GO :0004842 : ubiquitin-protein transferase activity and also this GO :0004871 : signal transducer activity and also this GO :0005164 : tumor necrosis factor receptor binding and also this GO :0005515 : protein binding and also this GO :0008270 : zinc ion binding and also this GO :0016874 : ligase activity and also this GO :0019901 : protein kinase binding and also this GO :0031625 : ubiquitin protein ligase binding and also this GO :0031996 : thioesterase binding, this GO :0004871 : signal transducer activity, this GO :0005164 : tumor necrosis factor receptor binding, this GO :0005515 : protein binding, this GO :0008270 : zinc ion binding, this GO :0016874 : ligase activity, this GO :0019901 : protein kinase binding, this GO :0031625 : ubiquitin protein ligase binding, this GO :0031996 : thioesterase binding, TNF receptor-associated factor 3 |
| Identity: |
12033 |
| Gene: |
TRAF3 |
More about : TRAF3 |
| Long gene name: |
TNF receptor associated factor 3 |
| Locus: |
14q32, 32 |
| Discovery year: |
1998-05-05 |
| GenBank acession: |
U21092 |
| Entrez gene record: |
7187 |
| Pubmed identfication: |
7530216 7859281 |
| RefSeq identity: |
NM_145725 |
| Classification: |
Zinc fingers TNF receptor associated factors |
| Havana BLAST/BLAT: |
OTTHUMG00000171902 |
| Locus Specific Databases: |
LRG_229 |