| Long name: |
HEXA/Beta hexosaminidase subunit alpha Antibody |
| Also known as: |
HEXA/Beta hexosaminidase subunit alpha Antibody |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
HEXA/Beta hexosaminidase subunit alpha |
| Specificity: |
This is a highly specific antibody against HEXA/Beta hexosaminidase subunit alpha |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Beta hexosaminidase subunit alpha |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
A mutation in the &, HEXA, TSD is a fatal autosomal recessive lysosomal storage disease of the central nervous system (CNS) caused by insufficient activity of the HEXA enzyme that results in a failure to process GM2 gangliosides, The accumulation of GM2 ganglioside in the absence of HEXA activity causes progressive destruction of the CNS, along with the cofactor CM2 activator protein, also designated beta-Hexosaminidase A, also known as GM2-gangliosidosis type I, catalyzes the degradation of GM2 ganglioside and other molecules containing terminal N-acetyl hexosamines in the brain and other tissues, chain, is a trimer composed of one &, one â, subunit of hexosaminidase is the cause of Tay-Sachs disease (TSD), &circ, &circ, «, «, -A chain and one â, -B chain and is found in the lysosomes of cells, Hexosaminidase A (HEXA), aring, aring |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
Beta N acetylhexosaminidase, Beta N acetylhexosaminidase subunit alpha, Beta hexosaminidase subunit alpha, Beta-N-acetylhexosaminidase subunit alpha, Beta-hexosaminidase subunit alpha, HEXA_HUMAN, Hexa, Hexosaminidase A, Hexosaminidase A alpha polypeptide, Hexosaminidase A alpha polypeptide, Hexosaminidase subunit A, MGC99608, N acetyl beta glucosaminidase, N acetyl beta glucosaminidase subunit alpha, N-acetyl-beta-glucosaminidase subunit alpha, TSD, Beta hexosaminidase alpha chain precursor |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
HEXA/Beta hexosaminidase subunit alpha |
| Short name: |
HEXA/Beta hexosaminidase subunit alpha Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
HEXA/b hexosaminidase functionnal sequence a (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
4878 |
| Gene: |
HEXA |
More about : HEXA |
| Long gene name: |
hexosaminidase subunit alpha |
| Synonyms gene name: |
hexosaminidase A (alpha polypeptide) |
| Synonyms name: |
Tay Sachs disease GM2 gangliosidosis beta-hexosaminidase subunit alpha |
| Locus: |
15q23 |
| Discovery year: |
2001-06-22 |
| GenBank acession: |
M13520 |
| Entrez gene record: |
3073 |
| Pubmed identfication: |
2952641 3013851 |
| RefSeq identity: |
NM_000520 |
| Havana BLAST/BLAT: |
OTTHUMG00000133445 |
| Locus Specific Databases: |
Hexosaminidase A, Tay-Sachs Disease ALSOD, the Amyotrophic Lateral Sclerosis Online Genetic Database |