| Long name: |
ALEXA FLUOR 488 Conjugated, ALS2/Alsin Polyclonal Antibody |
| Also known as: |
Anti-ALS2/Alsin PAb ALEXA FLUOR 488 |
| Category: |
Conjugated Primary Antibodies |
| Conjugated with: |
488, ALEXA FLUOR® |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
ALS2/Alsin |
| Specificity: |
This is a highly specific antibody against ALS2/Alsin |
| Modification: |
Unmodified |
| Modification Site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human ALS2 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Cross-reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the antigen: |
Alsin acts as a guanine nucleotide exchange factor for Rab5, Alsin is a cytosolic protein that is associated with small, Alsin may mediate membrane transport events, The ALS2 C-terminal-like protein (ALS2CL) also modulates Rab 5 activity, The ALS2 gene encodes the Alsin protein, Therefore, a modulator of the endocytic pathway, a recessive form of amyotrophic lateral sclerosis (ALS2), and a form of complicated hereditary spastic paraplegia (cHSP), including juvenile primary lateral sclerosis (JPLS), infantile onset ascending hereditary spastic paralysis (IAHSP), potentially linking endocytic processes and actin cytoskeleton remodeling, punctate membrane structures, Mutations in the ALS2 gene result in a number of juvenile recessive motor neuron diseases (MNDs) |
| Purification: |
Purified by Protein A |
| Storage conditions: |
50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA |
| Excitation emission: |
499nm/519nm |
| Properties: |
ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 488 has the same range to that of fluorescein isothiocyanate (FITC), Also Alexa Fluor 488 is pH stable, As a result of this photo stability, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, It is distinguished in the FL1 of a FACS-Calibur or FACScan, has a very high photo stability, it has turned into an antibody for fluorescent microscopy and FACS FLOW cytometry, yet the ALS2/Alsin Antibody, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Gene target: |
ALS2/Alsin |
| Short name: |
ALS2/Alsin Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Label: |
ALEXA FLUOR 488 |
| Alternative name: |
ALEXA FLUOR 488, ALS2/Alsin (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
443 |
| Gene: |
ALS2 |
More about : ALS2 |
| Long gene name: |
ALS2, alsin Rho guanine nucleotide exchange factor |
| Synonyms gene: |
ALS2CR6 |
| Synonyms gene name: |
amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 6 amyotrophic lateral sclerosis 2 (juvenile) |
| Synonyms name: |
alsin |
| Locus: |
2q33, 1 |
| Discovery year: |
1992-11-19 |
| GenBank acession: |
AB053305 |
| Entrez gene record: |
57679 |
| Pubmed identfication: |
11586298 |
| RefSeq identity: |
NM_020919 |
| Classification: |
Rho guanine nucleotide exchange factors VPS9 domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000154507 |
| Locus Specific Databases: |
ALSOD, the Amyotrophic Lateral Sclerosis Online Genetic Database LRG_654 |