| Long name: |
HIP1 Primary Polyclonal Antibody |
| Also known as: |
HIP1 PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
HIP1 |
| Specificity: |
This is a highly specific antibody against HIP1 |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human HIP1 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
HIP1 (huntingtin-interacting protein 1), HIP1 contains an endocytic multidomain protein with a C-terminal Actin-binding domain, HIP1 is ubiquitously expressed in different brain regions at low levels, HIP1 may be involved in vesicle trafficking, HIP12 differs from HIP1 in its pattern of expression at both the mRNA and protein level, HIP12 does not directly interact with huntingtin but can interact with HIP1, HIP12 is a non-proapoptotic member of the HIP gene family that is expressed in the brain and shares a similar subcellular distribution pattern with HIP1, However, The huntingtin-HIP1 interaction is restricted to the brain and is inversely correlated to the polyglutamine length in the huntingtin, a central coiled-coil forming region and an N-terminal ENTH domain, a membrane-associated protein, and exhibits nearly identical subcellular fractionation as huntingtin, binds specifically to the N-terminus of human huntingtin, greater than 35 repeats, in the HD gene product huntingtin, suggesting that loss of normal huntingtin-HIP1 interaction may compromise the membrane-cytoskeletal integrity in the brain, the structural integrity of HIP1 is crucial for maintenance of normal vesicle size in vivo, Huntington disease is associated with the expansion of a polyglutamine tract |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
HIP I, HIP-1, HIP-I, HIP1/PDGFRB fusion gene, HIP1/PDGFRB fusion gene, HIP1_HUMAN, HIPI, Huntingtin interacting protein 1, Huntingtin-interacting protein 1, Huntingtin-interacting protein I, ILWEQ, KIAA4113, MGC126506, MGC27616, hip1, included, mKIAA4113, Huntingtin Interacting Protein HIP1 |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
HIP1 |
| Short name: |
HIP1 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
huntingtin interacting protein 1 (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
DNA-templated and biological process this GO :0006355 and regulation of transcription, DNA-templated and biological process this GO :0006897 and endocytosis and biological process this GO :0006915 and apoptotic process and biological process this GO :0006919 and activation of cysteine-type endopeptidase activity involved in apoptotic process and biological process this GO :0016020 and membrane and cellular component this GO :0030136 and clathrin-coated vesicle and cellular component this GO :0030154 and cell differentiation and biological process this GO :0030276 and clathrin binding and molecular function this GO :0030665 and clathrin-coated vesicle membrane and cellular component this GO :0035091 and phosphatidylinositol binding and molecular function this GO :0042981 and regulation of apoptotic process and biological process this GO :0043231 and intracellular membrane-bounded organelle and cellular component this GO :0048260 and positive regulation of receptor-mediated endocytosis and biological process this GO :0048268 and clathrin coat assembly and biological process this GO :0097190 and apoptotic signaling pathway and biological process, HIP-I and ILWEQ, HIP1 and IDBG-22641 and ENSG00000127946 and 3092, HIP1 and IDBG-640092 and ENSBTAG00000000781 and 505919, Hip1 and IDBG-203840 and ENSMUSG00000039959 and 215114, nuclei, phosphatidylinositol binding, this GO :0003779 and actin binding and molecular function this GO :0005200 and structural constituent of cytoskeleton and molecular function this GO :0005488 and binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005543 and phospholipid binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005794 and this GO lgi apparatus and cellular component this GO :0005856 and cytoskeleton and cellular component this GO :0006351 and transcription, this GO :0003779 : actin binding, this GO :0003779 : actin binding and also this GO :0005200 : structural constituent of cytoskeleton and also this GO :0005488 : binding and also this GO :0005515 : protein binding and also this GO :0005543 : phospholipid binding and also this GO :0030276 : clathrin binding and also this GO :0035091 : phosphatidylinositol binding, this GO :0005200 : structural constituent of cytoskeleton, this GO :0005488 : binding, this GO :0005515 : protein binding, this GO :0005543 : phospholipid binding, this GO :0030276 : clathrin binding, this GO :0035091 : phosphatidylinositol binding, huntingtin interacting protein 1 |
| Identity: |
4913 |
| Gene: |
HIP1 |
More about : HIP1 |
| Long gene name: |
huntingtin interacting protein 1 |
| Synonyms: |
ILWEQ |
| Locus: |
7q11, 23 |
| Discovery year: |
1997-08-28 |
| GenBank acession: |
AF052288 |
| Entrez gene record: |
3092 |
| Pubmed identfication: |
9140394 9147654 |
| RefSeq identity: |
NM_005338 |
| Havana BLAST/BLAT: |
OTTHUMG00000156050 |