| Long name: |
IMP4/SPPL2B Primary Polyclonal Antibody |
| Also known as: |
IMP4/SPPL2B PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
IMP4/SPPL2B |
| Specificity: |
This is a highly specific antibody against IMP4/SPPL2B |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human SPPL2B |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Four isoforms of SPPL2b exist due to alternative splicing events, Localized to the membrane of the Golgi apparatus and to lysosomes, SPPL2b also interacts with and catalyzes the intramembrane proteolysis of ITM2B (integral membrane protein 2B), SPPL2b functions as an intramembrane protease that specifically cleaves the transmembrane domain of TNF? Once cleaved, TNF?releases its intracellular domain, a protein that, endosomes and the plasma membrane, is associated with dementia, thus triggering the immunity-related expression of cytokines (also known as interleukins) which are used in various pathways throughout the body, when mutated, SPPL2b is a 592 amino acid multi-pass membrane protein that contains one protease associated domain and belongs to the GXGD family of aspartic proteases |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
Intramembrane protease 4, Protein SPP-like 2B, SPP2B_HUMAN, SPPL2B, Signal peptide peptidase-like 2B, IMP4 |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
IMP4/SPPL2B |
| Short name: |
IMP4/SPPL2B Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
IMP4/SPPL2B (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
30856 |
| Gene: |
IMP4 |
More about : IMP4 |
| Long gene name: |
IMP4 homolog, U3 small nucleolar ribonucleoprotein |
| Synonyms gene name: |
IMP4, U3 small nucleolar ribonucleoprotein, U3 small nucleolar ribonucleoprotein , homolog (yeast) IMP4 |
| Synonyms: |
MGC19606 BXDC4 |
| Locus: |
2q21, 1 |
| Discovery year: |
2005-02-21 |
| GenBank acession: |
BC010042 |
| Entrez gene record: |
92856 |
| Pubmed identfication: |
8619474 9110174 12655004 |
| RefSeq identity: |
NM_033416 |
| Havana BLAST/BLAT: |
OTTHUMG00000131627 |