| Long name: |
UCHL3 Primary Polyclonal Antibody |
| Also known as: |
UCHL3 PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
UCHL3 |
| Specificity: |
This is a highly specific antibody against UCHL3 |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
130-180/230 |
| Subcellular location: |
Cytoplasm |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human UCHL3 |
| Gene ID number: |
7347 |
| Swiss Prot: |
P15374 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Examination of specific brain regions reveals expression in all areas tested, Expression of UCH-L1 is highly specific to neurons and to cells of the diffuse neuroendocrine system and their tumors, Its occurrence in Lewy bodies and its function in the proteasome pathway make it a compelling candidate gene in Parkinson disease, The 230 amino acid human UCH-L3 protein is 54% identical to that of UCH-L1, The gene which encodes UCH-L1 maps to human chromosome 4p14, UCH-L1 is expressed in brain neurons, UCH-L1 represents 1 to 2% of total soluble brain protein, UCH-L3 is the predominant thiol protease and has high-affinity binding sites for ubiquitin, particularly in the substantia nigra, UCH-L1 is a member of a gene family whose products hydrolyze small C-terminal adducts of ubiquitin to generate the ubiquitin monomer |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
UCH L3, UCH-L3, UCHL3, UCHL3_HUMAN, Ubiquitin thioesterase L3, Ubiquitin thiolesterase, Ubiquitin thiolesterase L3, Ubiquitin carboxyl-terminal hydrolase isozyme L3 |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
UCHL3 |
| Short name: |
UCHL3 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
UCHL3 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
12515 |
| Gene: |
UCHL3 |
More about : UCHL3 |
| Long gene name: |
ubiquitin C-terminal hydrolase L3 |
| Synonyms gene name: |
ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase) |
| Synonyms name: |
ubiquitin thiolesterase |
| Locus: |
13q22, 2 |
| Discovery year: |
1991-07-15 |
| GenBank acession: |
M30496 |
| Entrez gene record: |
7347 |
| Pubmed identfication: |
2530630 |
| RefSeq identity: |
NM_006002 |
| Classification: |
Ubiquitin C-terminal hydrolases |
| Havana BLAST/BLAT: |
OTTHUMG00000017090 |