| Long name: |
Cy5, 5 Conjugated, HCN2 + HCN4 Polyclonal Antibody |
| Category: |
Conjugated Primary Antibodies |
| Conjugation: |
Cy5, 5, 5, Cy5 |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
HCN2 + HCN4 |
| Specificity: |
This is a highly specific antibody against HCN2 + HCN4 |
| Modification: |
Unmodified |
| Modification site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
KLH conjugated synthetic peptide derived from human HCN2 + HCN4 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Crossreactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Antigen background: |
HCN currents have been linked to pacemaker activity in the heart and brain, HCN1 and HCN2 play an important role for motor learning and neuronal integration by cerebellar Purkinje cells, HCN2 is a member of a family of pacemaker channels activated by hyperpolarization and regulated by cyclic nucleotides, HCN2 is highly abundant in mamillary bodies, HCN4 is another member of the family of hyperpolarization activated and cyclic nucleotide gated channels, It has been shown that HCN4 channels function as receptors for sour taste, and are associated with pacemaker potential generation in the sinoatrial node, and nucleus of the trapezoid body, as well as, as well as neuronal plasticity, contribute to spontaneous rhythmic activity in both heart and brain, pontine nucleus, resting potential control, shaping autonomous activity of single neurons and the periodicity of network oscillations, ventral cochlear nucleus, Hyperpolarization activated cation channels of the HCN gene family such as HCN2 |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA |
| Excitation Emission: |
675nm/694nm |
| Properties: |
Cy5 antibodies are excited by the 650-nanometer wave of an argon laser and detected at a 670-nanometer captor, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24° |
| Conjugated: |
These antibodies are excite for emission at 678nm and detected at a 694 , nm wavelengths |
| Gene target: |
HCN2 + HCN4 Conjugated |
| Short name: |
Conjugated, HCN2 + HCN4 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, antibody Conjugates, Antibody |
| Label: |
5, Cy5 |
| Alternative name: |
cyanine 5, 5 coupled, HCN2 and HCN4 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
16882 |
| Gene: |
HCN4 |
More about : HCN4 |
| Long gene name: |
hyperpolarization activated cyclic nucleotide gated potassium channel 4 |
| Synonyms gene name: |
hyperpolarization activated cyclic nucleotide-gated potassium channel 4 |
| Locus: |
15q24, 1 |
| Discovery year: |
2002-09-02 |
| GenBank acession: |
AJ132429 |
| Entrez gene record: |
10021 |
| Pubmed identfication: |
10228147 10430953 16382102 |
| RefSeq identity: |
NM_005477 |
| Classification: |
Cyclic nucleotide gated channels |
| Havana BLAST/BLAT: |
OTTHUMG00000137563 |