| Long name: |
Nicalin/NCLN Primary Polyclonal Antibody |
| Also known as: |
Nicalin/NCLN PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
Nicalin/NCLN |
| Specificity: |
This is a highly specific antibody against Nicalin/NCLN |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Nicalin |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Nicalin, Nodal signaling is an important factor for melanoma cell invasiveness and tumorigenicity and inhibition of this signal can promote melanoma cells reverting back toward a melanocyte phenotype, Nodals are TGF beta signaling factors that control various cell fate decisions during embryonic body planning stages in vertebrate development, The Nicalin/NOMO complex acts to regulate the nodal signaling factors during gastrulation, This regulation most often affects the development of the axial mesoderm, a nicastrin-like protein, is not associated with gamma-secretase but rather interacts with NOMO (Nodal modulator), Nicastrin is an integral part of the Alzheimers associated gamma-secretase complex |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
NCLN_HUMAN, NET59, Nicalin, Nicalin homolog zebrafish, Nicastrin like protein, Nicastrin-like protein, NCLN |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
Nicalin/NCLN |
| Short name: |
Nicalin/NCLN Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
Nicalin/NCLN (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
26923 |
| Gene: |
NCLN |
More about : NCLN |
| Long gene name: |
nicalin |
| Synonyms gene name: |
nicalin homolog (zebrafish) |
| Synonyms: |
NICALIN NET59 |
| Synonyms name: |
nicastrin-like protein |
| Locus: |
19p13, 3 |
| Discovery year: |
2004-11-26 |
| GenBank acession: |
BC025926 |
| Entrez gene record: |
56926 |
| Pubmed identfication: |
11230166 |
| RefSeq identity: |
NM_020170 |
| Havana BLAST/BLAT: |
OTTHUMG00000180687 |