| Long name: |
CHN 1/Alpha-chimerin Primary Polyclonal Antibody |
| Also known as: |
CHN 1/Alpha-chimerin PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
CHN 1/Alpha-chimerin |
| Specificity: |
This is a highly specific antibody against CHN 1/Alpha-chimerin |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Alpha-chimerin |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Alpha1-chimaerin expression is down-regulated resulting in an increase in spine growth and dendritic branching, Alpha1-chimaerin plays a significant role in the regulation of dendritic growth during neuronal development, By inactivating Rac 1, In the presence of reduced neuronal activity, It is recruited to the plasma membrane by phospholipase C Beta-coupled cell surface receptors activating the downstream generation of DAG (diacylglycerol), Overexpression of Alpha1-chimaerin results in dendritic spine retraction and the loss of dendritic branches, The ?-chimaerin variant is a neuron-specific, This variant lacks the N-terminal SH2 domain that is present in the Alpha2 variant, diacylglycerol-binding and GTPase-activating protein for ras-related protein Rac 1, The Rac-GAP chimaerin family member Alpha-chimaerin (also known as N-chimaerin or rho GTPase-activating protein 2) has two splice variants: Alpha1 and Alpha2 |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
ARHGAP2, Alpha-chimerin, CHIN_HUMAN, CHN, Chn1, N chimaerin, N chimerin, N-chimaerin, N-chimerin, NC, RHOGAP2, Rho GTPase-activating protein 2, A-chimaerin |
| Description: |
- or alpha protein sometimes glycoprotein present in blood, The CHN 1/Alpha-chimerin Antibody is a &alpha |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
CHN 1/Alpha-chimerin |
| Short name: |
CHN 1/Alpha-chimerin Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
CHN 1/a-chimerin (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
1943 |
| Gene: |
CHN1 |
More about : CHN1 |
| Long gene name: |
chimerin 1 |
| Synonyms gene: |
CHN DURS2 |
| Synonyms gene name: |
Duane retraction syndrome 2 chimerin (chimaerin) 1 |
| Synonyms: |
RhoGAP2 ARHGAP2 n-chimerin |
| Synonyms name: |
2) chimaerin 1 , Chimerin 1 (GTPase-activating protein, rho |
| Locus: |
2q31, 1 |
| Discovery year: |
1991-07-12 |
| Entrez gene record: |
1123 |
| Pubmed identfication: |
2299665 15013773 18653847 |
| RefSeq identity: |
NM_001822 |
| Classification: |
SH2 domain containing Rho GTPase activating proteins |
| Havana BLAST/BLAT: |
OTTHUMG00000154225 |