| Long name: |
ALEXA FLUOR 555 Conjugated, NCF1/p47 phox(Ser359) Antibody |
| Also known as: |
Anti-NCF1/p47 phox Ser359 PAb ALEXA FLUOR 555 |
| Category: |
Conjugated Primary Antibodies |
| Conjugated with: |
555, ALEXA FLUOR® |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
NCF1/p47 phox Ser359 |
| Specificity: |
This is a highly specific antibody against NCF1/p47 phox Ser359 |
| Modification: |
Phosphorylation |
| Modification Site: |
Ser359 |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
KLH conjugated synthetic phosphopeptide derived from human NCF1 around the phosphorylation site of Ser359 |
| Gene ID Number: |
653361 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Rat, Human |
| Cross-reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the antigen: |
Both p47-phox and p67-phox contain two Src homology 3 (SH3) domains, During activation of the NADPH oxidase, The C-terminal SH3 domain of p67-phox has been shown to interact with the proline-rich domain of p47-phox, The cytosolic proteins p47-phox and p67-phox, also designated neutrophil cytosol factor (NCF)1 and NCF2, are required for activation of the superoxide-producing NADPH oxidase in neutrophils and other phagocytic cells, p47-phox and p67-phox migrate to the plasma membrane where they associate with cytochrome b558 and the small G protein Rac to form the functional enzyme complex, respectively, suggesting that p47-phox may faciliate the transport of p67-phox to the membrane, The heredity chronic granulomatous disease (CGF) has been linked to mutations in p47-phox and p67-phox |
| Purification: |
Purified by Protein A |
| Storage conditions: |
50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA |
| Excitation emission: |
553nm/568nm |
| Synonyms: |
p47phox NOXO2 NCF1A SH3PXD1A |
| Properties: |
ALEXA FLUOR they should be stored frozen at - 24°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, Very high photo stable ALEXA conjugate, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
ALEXA FLUOR 555, Alexa Fluor |
| Gene target: |
NCF1/p47 phox(Ser359) |
| Short name: |
NCF1/p47 phox(Ser359) Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Label: |
ALEXA FLUOR 555 |
| Alternative name: |
ALEXA FLUOR 555, neutrophil cytosolic factor 1/p47 phox(Ser359) (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
NCF1 and IDBG-21570 and ENSG00000158517 and 653361, NCF1 and IDBG-639883 and ENSBTAG00000003305 and 281345, Ncf1 and IDBG-202592 and ENSMUSG00000015950 and 17969, Plasma membranes, TAP-dependent and biological process this GO :0002679 and respiratory burst involved in defense response and biological process this GO :0005515 and protein binding and molecular function this GO :0005737 and cytoplasm and cellular component this GO :0005791 and rough endoplasmic reticulum and cellular component this GO :0005794 and this GO lgi apparatus and cellular component this GO :0005829 and cytosol and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0006612 and protein targeting to membrane and biological process this GO :0006691 and leukotriene metabolic process and biological process this GO :0006801 and superoxide metabolic process and biological process this GO :0006915 and apoptotic process and biological process this GO :0006954 and inflammatory response and biological process this GO :0006968 and cellular defense response and biological process this GO :0008283 and cell proliferation and biological process this GO :0009055 and electron carrier activity and molecular function this GO :0009617 and response to bacterium and biological process this GO :0016020 and membrane and cellular component this GO :0016175 and superoxide-generating NADPH oxidase activity and molecular function this GO :0017124 and SH3 domain binding and molecular function this GO :0019898 and extrinsic component of membrane and cellular component this GO :0030425 and dendrite and cellular component this GO :0032010 and pha this GO lysosome and cellular component this GO :0035091 and phosphatidylinositol binding and molecular function this GO :0042554 and superoxide anion generation and biological process this GO :0042590 and antigen processing and presentation of exogenous peptide antigen via MHC class I and biological process this GO :0042742 and defense response to bacterium and biological process this GO :0043020 and NADPH oxidase complex and cellular component this GO :0043025 and neuronal cell body and cellular component this GO :0043325 and phosphatidylinositol-3, phosphatidylinositol-3, this GO :0001878 and response to yeast and biological process this GO :0001909 and leukocyte mediated cytotoxicity and biological process this GO :0002474 and antigen processing and presentation of peptide antigen via MHC class I and biological process this GO :0002479 and antigen processing and presentation of exogenous peptide antigen via MHC class I, this GO :0005515 : protein binding, this GO :0005515 : protein binding and also this GO :0009055 : electron carrier activity and also this GO :0016175 : superoxide-generating NADPH oxidase activity and also this GO :0017124 : SH3 domain binding and also this GO :0035091 : phosphatidylinositol binding and also this GO :0043325 : phosphatidylinositol-3, this GO :0009055 : electron carrier activity, this GO :0016175 : superoxide-generating NADPH oxidase activity, this GO :0017124 : SH3 domain binding, this GO :0035091 : phosphatidylinositol binding, this GO :0043325 : phosphatidylinositol-3, 4-bisphosphate binding, 4-bisphosphate binding, 4-bisphosphate binding and molecular function this GO :0045087 and innate immune response and biological process this GO :0045730 and respiratory burst and biological process this GO :0045986 and negative regulation of smooth muscle contraction and biological process this GO :0050665 and hydrogen peroxide biosynthetic process and biological process this GO :0050830 and defense response to Gram-positive bacterium and biological process this GO :0050832 and defense response to fungus and biological process this GO :0051701 and interaction with host and biological process this GO :0055114 and oxidation-reduction process and biological process this GO :0070946 and neutrophil mediated killing of gram-positive bacterium and biological process this GO :0070947 and neutrophil mediated killing of fungus and biological process this GO :0090382 and pha this GO some maturation and biological process, neutrophil cytosolic factor 1 |
| Identity: |
7660 |
| Gene: |
NCF1 |
More about : NCF1 |
| Long gene name: |
neutrophil cytosolic factor 1 |
| Synonyms gene name: |
autosomal 1) , chronic granulomatous disease, neutrophil cytosolic factor 1 (47kD |
| Synonyms name: |
NADPH oxidase organizer 2 chronic granulomatous disease, autosomal 1 |
| Locus: |
7q11, 23 |
| Discovery year: |
1989-05-25 |
| GenBank acession: |
M25665 |
| Entrez gene record: |
653361 |
| RefSeq identity: |
NM_000265 |
| Havana BLAST/BLAT: |
OTTHUMG00000149965 |
| Locus Specific Databases: |
NCF1base: Mutation registry for autosomal recessive chronic granulomatous disease (CGD), deficiency of p47phox LRG_87 |