| Long name: |
AKR1C3/DD3 Primary Polyclonal Antibody |
| Also known as: |
AKR1C3/DD3 PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
AKR1C3/DD3 |
| Specificity: |
This is a highly specific antibody against AKR1C3/DD3 |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human AKR1C3 |
| Gene ID number: |
8644 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
AKR1C3 and 3Alpha-HSD are alternate designations for DD3, BABP or DDH2, CD or CHDR, DD1 and DD2 are 20Alpha-HSDs, DD1 and DD2 are ubiquitously expressed, DD1 is also designated AKR1C1, DD2, DD3 and DD4), DDH or DDH1 while DD2 also can be designated AKR1C2, NADPH-dependent oxidoreductase that reduces 3-keto-5-dihydrosteroids to their tetrahydro products, The 20Alpha-HSD catalyzes the reaction of progesterone to the inactive form 20Alpha-hydroxyprogesterone, The 3Alpha-HSD is a cytosolic, The multiple human cytosolic dihydrodiol dehydrogenases are involved in the metabolism of xenobiotics, and are responsible for the reduction of ketone-containing drugs by using NADH or NADPH as a cofactor, dDD, have 20Alpha- or 3Alpha-hydroxysteroid dehydrogenase (HSD) activity, monomeric, pesticides and steroid hormones, such as polycyclic aromatic hydrocarbons, whereas DD3 and DD4 are the 3Alpha-HSDs, whereas DD4 mRNA is restricted to the liver, which belong to the aldo-oxo reductase/aldo-keto reductase (AKR) superfamily, while DD4 also can be called AKR1C4, #65279, &, DD3 is a unique enzyme that can specifically catalyze the dehydrogenation of trans-benzenedihydrodiol and trans-naphthalenedihydrodiol, Human liver contains isoforms of dihydrodiol dehydrogenase (DD1 |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
17 beta hydroxysteroid dehydrogenase type 5, 17-beta-HSD 5, 17-beta-hydroxysteroid dehydrogenase type 5, 2-dihydrobenzene-1, 2-diol dehydrogenase, 3 alpha hydroxysteroid dehydrogenase type II, 3-alpha-HSD type 2, 3-alpha-HSD type II, 3-alpha-HSD type II, 3-alpha-hydroxysteroid dehydrogenase type 2, AK1C3_HUMAN, AKR1 C3, AKR1C3, Aldo keto reductase family 1 member C3, Aldo-keto reductase family 1 member C3, Chlordecone reductase, Chlordecone reductase homolog HAKRb, DD-3, DD3, DDH1, DDX, Dihydrodiol dehydrogenase 3, Dihydrodiol dehydrogenase X, Dihydrodiol dehydrogenase type I, HA1753, HAKRB, HAKRe, HSD17B5, Indanol dehydrogenase, KIAA0119, PGFS, Prostaglandin F synthase, Testosterone 17-beta-dehydrogenase 5, Trans-1, Trans-1, Type IIb 3 alpha hydroxysteroid dehydrogenase, brain, brain, hluPGFS, 17 beta HSD 5, 2-dihydrobenzene-1, 2-diol dehydrogenase |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
AKR1C3/DD3 |
| Short name: |
AKR1C3/DD3 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
classification II)/DD3 (Antibody to), member complement component 3 (3-a hydroxysteroid dehydrogenase, aldo-keto reductase family 1 |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
AKR1C3 and IDBG-47964 and ENSG00000196139 and 8644, DD3 and DDX and HA1753 and HAKRB and HAKRe and hluPGFS and HSD17B5 and PGFS, acting on NAD(P)H, acting on NAD(P)H, acting on NAD(P)H, member C3 (3-alpha hydroxysteroid dehydrogenase, nuclei, oxidoreductase activity, quinone or similar compound as acceptor, quinone or similar compound as acceptor and also this GO :0018636 : phenanthrene 9, quinone or similar compound as acceptor and molecular function this GO :0018636 and phenanthrene 9, this GO :0000060 and protein import into nucleus, this GO :0001758 : retinal dehydrogenase activity, this GO :0001758 : retinal dehydrogenase activity and also this GO :0004032 : alditol:NADP+ 1-oxidoreductase activity and also this GO :0004033 : aldo-keto reductase (NADP) activity and also this GO :0004745 : retinol dehydrogenase activity and also this GO :0004958 : prostaglandin F receptor activity and also this GO :0016491 : oxidoreductase activity and also this GO :0016655 : oxidoreductase activity, this GO :0004032 : alditol:NADP+ 1-oxidoreductase activity, this GO :0004033 : aldo-keto reductase (NADP) activity, this GO :0004745 : retinol dehydrogenase activity, this GO :0004958 : prostaglandin F receptor activity, this GO :0016491 : oxidoreductase activity, this GO :0016655 : oxidoreductase activity, this GO :0018636 : phenanthrene 9, this GO :0035410 : dihydrotestosterone 17-beta-dehydrogenase activity, this GO :0036131 : prostaglandin D2 11-ketoreductase activity, this GO :0045550 : geranylgeranyl reductase activity, this GO :0045703 : ketoreductase activity, this GO :0047017 : prostaglandin-F synthase activity, this GO :0047020 : 15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity, this GO :0047023 : androsterone dehydrogenase activity, this GO :0047035 : testosterone dehydrogenase (NAD+) activity, this GO :0047045 : testosterone 17-beta-dehydrogenase (NADP+) activity, this GO :0047086 : ketosteroid monooxygenase activity, this GO :0047115 : trans-1, this GO :0047718 : indanol dehydrogenase activity, this GO :0047787 : delta4-3-oxosteroid 5beta-reductase activity, translocation and biological process this GO :0001523 and retinoid metabolic process and biological process this GO :0001758 and retinal dehydrogenase activity and molecular function this GO :0004032 and alditol:NADP+ 1-oxidoreductase activity and molecular function this GO :0004033 and aldo-keto reductase (NADP) activity and molecular function this GO :0004745 and retinol dehydrogenase activity and molecular function this GO :0004958 and prostaglandin F receptor activity and molecular function this GO :0005622 and intracellular and cellular component this GO :0005634 and nucleus and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005829 and cytosol and cellular component this GO :0006693 and prostaglandin metabolic process and biological process this GO :0007186 and G-protein coupled receptor signaling pathway and biological process this GO :0007584 and response to nutrient and biological process this GO :0007603 and phototransduction, type II), visible light and biological process this GO :0008202 and steroid metabolic process and biological process this GO :0008284 and positive regulation of cell proliferation and biological process this GO :0008584 and male this GO nad development and biological process this GO :0009267 and cellular response to starvation and biological process this GO :0010942 and positive regulation of cell death and biological process this GO :0016488 and farnesol catabolic process and biological process this GO :0016491 and oxidoreductase activity and molecular function this GO :0016655 and oxidoreductase activity, 10-monooxygenase activity, 10-monooxygenase activity and also this GO :0035410 : dihydrotestosterone 17-beta-dehydrogenase activity and also this GO :0036131 : prostaglandin D2 11-ketoreductase activity and also this GO :0045550 : geranylgeranyl reductase activity and also this GO :0045703 : ketoreductase activity and also this GO :0047017 : prostaglandin-F synthase activity and also this GO :0047020 : 15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity and also this GO :0047023 : androsterone dehydrogenase activity and also this GO :0047035 : testosterone dehydrogenase (NAD+) activity and also this GO :0047045 : testosterone 17-beta-dehydrogenase (NADP+) activity and also this GO :0047086 : ketosteroid monooxygenase activity and also this GO :0047115 : trans-1, 10-monooxygenase activity and molecular function this GO :0019369 and arachidonic acid metabolic process and biological process this GO :0019371 and cyclooxygenase pathway and biological process this GO :0030216 and keratinocyte differentiation and biological process this GO :0034614 and cellular response to reactive oxygen species and biological process this GO :0034694 and response to prostaglandin stimulus and biological process this GO :0035410 and dihydrotestosterone 17-beta-dehydrogenase activity and molecular function this GO :0036131 and prostaglandin D2 11-ketoreductase activity and molecular function this GO :0042448 and progesterone metabolic process and biological process this GO :0042574 and retinal metabolic process and biological process this GO :0044259 and multicellular organismal macromolecule metabolic process and biological process this GO :0044281 and small molecule metabolic process and biological process this GO :0044597 and daunorubicin metabolic process and biological process this GO :0044598 and doxorubicin metabolic process and biological process this GO :0045550 and geranylgeranyl reductase activity and molecular function this GO :0045703 and ketoreductase activity and molecular function this GO :0047017 and prostaglandin-F synthase activity and molecular function this GO :0047020 and 15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity and molecular function this GO :0047023 and androsterone dehydrogenase activity and molecular function this GO :0047035 and testosterone dehydrogenase (NAD+) activity and molecular function this GO :0047045 and testosterone 17-beta-dehydrogenase (NADP+) activity and molecular function this GO :0047086 and ketosteroid monooxygenase activity and molecular function this GO :0047115 and trans-1, 2-dihydrobenzene-1, 2-dihydrobenzene-1, 2-dihydrobenzene-1, 2-diol dehydrogenase activity, 2-diol dehydrogenase activity and also this GO :0047718 : indanol dehydrogenase activity and also this GO :0047787 : delta4-3-oxosteroid 5beta-reductase activity, 2-diol dehydrogenase activity and molecular function this GO :0047718 and indanol dehydrogenase activity and molecular function this GO :0047787 and delta4-3-oxosteroid 5beta-reductase activity and molecular function this GO :0048385 and regulation of retinoic acid receptor signaling pathway and biological process this GO :0051897 and positive regulation of protein kinase B signaling and biological process this GO :0055114 and oxidation-reduction process and biological process this GO :0061370 and testosterone biosynthetic process and biological process this GO :0070062 and extracellular vesicular exosome and cellular component this GO :0070293 and renal absorption and biological process this GO :0071276 and cellular response to cadmium ion and biological process this GO :0071277 and cellular response to calcium ion and biological process this GO :0071379 and cellular response to prostaglandin stimulus and biological process this GO :0071384 and cellular response to corticosteroid stimulus and biological process this GO :0071395 and cellular response to jasmonic acid stimulus and biological process this GO :1900053 and negative regulation of retinoic acid biosynthetic process and biological process this GO :2000224 and regulation of testosterone biosynthetic process and biological process this GO :2000353 and positive regulation of endothelial cell apoptotic process and biological process this GO :2000379 and positive regulation of reactive oxygen species metabolic process and biological process, aldo-keto reductase family 1 |
| Identity: |
386 |
| Gene: |
AKR1C3 |
More about : AKR1C3 |
| Long gene name: |
aldo-keto reductase family 1 member C3 |
| Synonyms gene: |
HSD17B5 |
| Synonyms gene name: |
hydroxysteroid (17-beta) dehydrogenase 5 aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II) |
| Synonyms: |
KIAA0119 DDX HAKRB PGFS |
| Synonyms name: |
dihydrodiol dehydrogenase X prostaglandin F synthase 3-alpha hydroxysteroid dehydrogenase, type II |
| Locus: |
10p15, 1 |
| Discovery year: |
1998-09-29 |
| GenBank acession: |
L43839 |
| Entrez gene record: |
8644 |
| Pubmed identfication: |
7650035 9792917 |
| RefSeq identity: |
NM_003739 |
| Classification: |
Aldo-keto reductases |
| Havana BLAST/BLAT: |
OTTHUMG00000017585 |