| Long name: |
CPLX1 Primary Polyclonal Antibody |
| Also known as: |
CPLX1 PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
CPLX1 |
| Specificity: |
This is a highly specific antibody against CPLX1 |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human CPLX1 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
A progressive loss of Complexin 2 occurs in the brains of mice carrying the Huntington disease mutation, Changes in the neurotransmitter release might contribute to the motor, Complexin 1 and Complexin 2 are expressed in presynaptic terminals of inhibitory and excitatory hippocampal neurons, Complexin 2 may play a role in LTP (long term potentiation) following tetanic stimulation, Complexins are important regulators of transmitter release at a late step in calcium dependent neurotransmitter release or immediately after the calcium-triggering step of fast synchronous transmitter release and preceding vesicle fusion, Complexins promote SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptors) precomplex formation by binding to synaxin with its a-helical domain, Neurons lacking complexins show reduced transmitter release efficiency due to decreased calcium sensitivity of the synaptic secretion process, also designated Synaphin 1 and Synaphin 2, an autosomal dominant neurodegenerative disorder, and in cytoplasmic pools during early stages of development, contain an a-helical middle domain of approximately 58 amino acids, emotional and cognitive dysfunctions seen in these mice, respectively, Complexin 1 and Complexin 2 |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
921-S, CPLX1, CPLX1_HUMAN, CPX I, CPX-I, CPX1, Complexin I, Complexin-1, Synaphin 2, Synaphin-2, complexin 1 |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
CPLX1 |
| Short name: |
CPLX1 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
complexin 1 (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
CPLX1 and IDBG-6120 and ENSG00000168993 and 10815, CPX-I and CPX1, Cplx1 and IDBG-188148 and ENSMUSG00000033615 and 12889, Cytoplasm, syntaxin binding, this GO :0000149 and SNARE binding and molecular function this GO :0005326 and neurotransmitter transporter activity and molecular function this GO :0005829 and cytosol and cellular component this GO :0006836 and neurotransmitter transport and biological process this GO :0006887 and exocytosis and biological process this GO :0007268 and synaptic transmission and biological process this GO :0007269 and neurotransmitter secretion and biological process this GO :0014047 and glutamate secretion and biological process this GO :0016079 and synaptic vesicle exocytosis and biological process this GO :0017075 and syntaxin-1 binding and molecular function this GO :0019905 and syntaxin binding and molecular function this GO :0030073 and insulin secretion and biological process this GO :0030425 and dendrite and cellular component this GO :0031201 and SNARE complex and cellular component this GO :0043025 and neuronal cell body and cellular component this GO :0043234 and protein complex and cellular component this GO :0045202 and synapse and cellular component this GO :0070032 and synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex and cellular component, this GO :0000149 : SNARE binding, this GO :0000149 : SNARE binding and also this GO :0005326 : neurotransmitter transporter activity and also this GO :0017075 : syntaxin-1 binding and also this GO :0019905 : syntaxin binding, this GO :0005326 : neurotransmitter transporter activity, this GO :0017075 : syntaxin-1 binding, this GO :0019905 : syntaxin binding, complexin 1 |
| Identity: |
2309 |
| Gene: |
CPLX1 |
More about : CPLX1 |
| Long gene name: |
complexin 1 |
| Synonyms: |
CPX-I |
| Locus: |
4p16, 3 |
| Discovery year: |
1999-09-09 |
| GenBank acession: |
AF022383 |
| Entrez gene record: |
10815 |
| Pubmed identfication: |
7553862 |
| Havana BLAST/BLAT: |
OTTHUMG00000160005 |