| Long name: |
ALEXA FLUOR 594 Conjugated, EPS15 Polyclonal Antibody |
| Also known as: |
Anti-EPS15 PAb ALEXA FLUOR 594 |
| Category: |
Conjugated Primary Antibodies |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
EPS15 |
| Specificity: |
This is a highly specific antibody against EPS15 |
| Modification: |
Unmodified |
| Modification Site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human EPS15 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Cross-reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the antigen: |
Eps15 is capable of binding the amino terminal portion of Crk via a conserved proline-rich domain, Eps8 and Eps15 are proteins, Eps8 has been shown to associate with the EGF receptor despite its lack of a functional SH2 domain, Further characterization suggests the protein has both a PH domain and a SH3 domain, Miscues in RTK signaling pathways can result in cellular transformation and ultimately in cancer, Overexpression of Eps15 in NIH/3T3 cells causes cellular transformation, Overexpression of Eps8 in both fibroblasts and hematopoietic cells results in an increased mitogenic response to EGF, Two novel EGF receptor substrates designated EGF-receptor pathway substrates 8 and 15, characteristic of all Crk binding proteins (5), have been described, implying involvement in the regulation of cell proliferation, or Eps8 and Eps15, respectively that become tyrosine phosphorylated subsequent to EGF stimulation, the functional significance of which are not yet known, Elucidation of the mechanism by which receptor tyrosine kinases (RTKs) modulate cellular physiology in response to stimuli is critical to the understanding of growth regulation |
| Purification: |
Purified by Protein A |
| Storage conditions: |
50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
AF-1P MLLT5 |
| Properties: |
ALEXA FLUOR they should be stored frozen at - 24°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
594, ALEXA FLUOR®, Alexa Fluor |
| Conjugated: |
Alexa conjugate 1 |
| Gene target: |
EPS15 |
| Short name: |
EPS15 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Label: |
ALEXA FLUOR 594 |
| Alternative name: |
ALEXA FLUOR 594, EPS15 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
3419 |
| Gene: |
EPS15 |
More about : EPS15 |
| Long gene name: |
epidermal growth factor receptor pathway substrate 15 |
| Locus: |
1p32, 3 |
| Discovery year: |
1994-12-19 |
| GenBank acession: |
BC054006 |
| Entrez gene record: |
2060 |
| Pubmed identfication: |
8183552 |
| RefSeq identity: |
NM_001981 |
| Classification: |
EF-hand domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000008192 |