| Long name: |
Biotin Conjugated, NCAM2 Polyclonal Antibody |
| Category: |
Conjugated Primary Antibodies |
| Conjugation: |
Biotinylated |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
NCAM2 |
| Specificity: |
This is a highly specific antibody against NCAM2 |
| Modification: |
Unmodified |
| Modification site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Subcellular location: |
Extracellular |
| Source: |
KLH conjugated synthetic peptide derived from human NCAM2 |
| Tested applications: |
IHC-P, WB |
| Recommended dilutions: |
IHC-P(1:100-500), WB(1:100-1000) |
| Crossreactivity: |
Mouse, Rat, Human |
| Crossreactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Antigen background: |
NCAM2 contains five immunoglobulin-like domains, NCAM2 is a considered a good candidate for involvement in certain Down syndrome phenotypes because a slight overexpression of NCAMs increases many-fold the homotypic adhesion properties of cells, NCAM2 is a member of the neural cell adhesion molecule (NCAM) family, NCAMs are closely related cell surface glycoproteins involved in cell to cell interactions during growth and are thought to play an important role in embryogenesis and development, Neither Stat1 nor Stat3 bind to this region, Stat5 regulates NCAM2 in vivo by binding to the NCAM2 intron in the NKL natural killer cell line, The gene is expressed most strongly in human adult and fetal brain, a transmembrane domain and a cytoplasmic domain, despite sharing a consensus binding sequence with Stat5, this binding is induced by cytokines that activate Stat5, two Fibronectin type III domains, NCAM2 is an 837 amino acid protein encoded by the human gene NCAM2 |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA |
| Synonyms: |
NCAM21 MGC51008 |
| Properties: |
Avidin and Streptavidin bind to the small biotin and are couple to HRP or AP for ELISA, Biotin conjugates can be detected by horseradish peroxidase, To break the streptavidin Biotin bond we suggest to use a 6 molar guanidine HCl solution with acidity of pH 1, alkaline phosphatase substrates or anti biotin conjugated antibodies, 6, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
NCAM2 Conjugated |
| Short name: |
Conjugated, NCAM2 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, antibody Conjugates, Antibody |
| Label: |
Biotin |
| Alternative name: |
biotinilated coupled, neural cellular adhesion molecule 2 (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
NCAM2 and IDBG-1027 and ENSG00000154654 and 4685, NCAM2 and IDBG-630332 and ENSBTAG00000003301 and 535613, NCAM21, Ncam2 and IDBG-172510 and ENSMUSG00000022762 and 17968, Plasma membranes, protein binding, this GO :0005515 and protein binding and molecular function this GO :0005886 and plasma membrane and cellular component this GO :0007158 and neuron cell-cell adhesion and biological process this GO :0007413 and axonal fasciculation and biological process this GO :0007608 and sensory perception of smell and biological process this GO :0016021 and integral component of membrane and cellular component this GO :0030424 and axon and cellular component, this GO :0005515 : protein binding, this GO :0005515 : protein binding, neural cell adhesion molecule 2 |
| Identity: |
7657 |
| Gene: |
NCAM2 |
More about : NCAM2 |
| Long gene name: |
neural cell adhesion molecule 2 |
| Locus: |
21q21, 1 |
| Discovery year: |
1997-04-25 |
| Entrez gene record: |
4685 |
| Pubmed identfication: |
9226371 |
| RefSeq identity: |
NM_004540 |
| Classification: |
Fibronectin type III domain containing I-set domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000078121 |