| Long name: |
Biotin Conjugated, AFAP1L2 Polyclonal Antibody |
| Category: |
Conjugated Primary Antibodies |
| Conjugation: |
Biotinylated |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
AFAP1L2 |
| Specificity: |
This is a highly specific antibody against AFAP1L2 |
| Modification: |
Unmodified |
| Modification site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
KLH conjugated synthetic peptide derived from human AFAP1L2 |
| Tested applications: |
IHC-P, WB |
| Recommended dilutions: |
IHC-P(1:100-500), WB(1:100-1000) |
| Crossreactivity: |
Mouse, Rat, Human |
| Crossreactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Antigen background: |
AFAP-110 contains additional protein-binding domains as well, AFAP-110 provides a platform for the preparation of larger signaling complexes, AFAP-1L2 (Actin filament-associated protein 1-like 2), AFAP-1L2 interacts with Src kinase and may play a role in Src-regulated transcription activation, AFAP-1L2 is expressed in thyroid and spleen and can also be detected at lower levels in lung, By linking signaling molecules to actin filaments, Like its relative AFAP110, There are four isoforms of AFAP-1L2 that are produced as a result of alternative splicing events, activates Src kinases in response to cellular signals and also directly affects Actin organization as an Actin filament cross-linking protein, also known as XB130, and serves as an adaptor protein, brain, is a 818 amino acid cytoplasmic protein that contains two Pleckstrin homology (PH) domains, pancreas and kidney, which are normally found in proteins involved in intracellular signaling, Actin filament associated protein (AFAP-110) interacts directly with actin filaments through its C-terminal actin-binding domain |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA |
| Synonyms: |
FLJ14564 Em:AC005383, 4 XB130 |
| Properties: |
Avidin and Streptavidin bind to the small biotin and are couple to HRP or AP for ELISA, Biotin conjugates can be detected by horseradish peroxidase, To break the streptavidin Biotin bond we suggest to use a 6 molar guanidine HCl solution with acidity of pH 1, alkaline phosphatase substrates or anti biotin conjugated antibodies, 6, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
AFAP1L2 Conjugated |
| Short name: |
Conjugated, AFAP1L2 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, antibody Conjugates, Antibody |
| Label: |
Biotin |
| Alternative name: |
biotinilated coupled, actin filament associated protein 1-like 2 (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
AFAP1L2 and IDBG-640002 and ENSBTAG00000004895 and 615436, AFAP1L2 and IDBG-90372 and ENSG00000169129 and 84632, Afap1l2 and IDBG-179434 and ENSMUSG00000025083 and 226250, Cytoplasm, DNA-templated and biological process this GO :0061098 and positive regulation of protein tyrosine kinase activity and biological process, SH2 domain binding, this GO :0005737 and cytoplasm and cellular component this GO :0006954 and inflammatory response and biological process this GO :0007346 and regulation of mitotic cell cycle and biological process this GO :0017124 and SH3 domain binding and molecular function this GO :0030296 and protein tyrosine kinase activator activity and molecular function this GO :0032675 and regulation of interleukin-6 production and biological process this GO :0032757 and positive regulation of interleukin-8 production and biological process this GO :0042169 and SH2 domain binding and molecular function this GO :0045742 and positive regulation of epidermal growth factor receptor signaling pathway and biological process this GO :0045893 and positive regulation of transcription, this GO :0017124 : SH3 domain binding, this GO :0017124 : SH3 domain binding and also this GO :0030296 : protein tyrosine kinase activator activity and also this GO :0042169 : SH2 domain binding, this GO :0030296 : protein tyrosine kinase activator activity, this GO :0042169 : SH2 domain binding, actin filament associated protein 1-like 2 |
| Identity: |
25901 |
| Gene: |
AFAP1L2 |
More about : AFAP1L2 |
| Long gene name: |
actin filament associated protein 1 like 2 |
| Synonyms gene: |
KIAA1914 |
| Synonyms gene name: |
KIAA1914 actin filament associated protein 1-like 2 |
| Locus: |
10q25, 3 |
| Discovery year: |
2004-02-18 |
| GenBank acession: |
BC024314 |
| Entrez gene record: |
84632 |
| Pubmed identfication: |
11572484 17412687 |
| RefSeq identity: |
NM_032550 |
| Classification: |
Pleckstrin homology domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000019086 |