| Long name: |
HRP Conjugated, CDK2 Polyclonal Antibody |
| Category: |
Conjugated Primary Antibodies |
| Conjugation: |
HRP Conjugated |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
CDK2 |
| Specificity: |
This is a highly specific antibody against CDK2 |
| Modification: |
Unmodified |
| Modification site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen_range: |
220-260/298 |
| Source: |
KLH conjugated synthetic peptide derived from human CDK2 |
| Gene ID number: |
1017 |
| Swiss Prot: |
P24941 |
| Tested applications: |
WB |
| Recommended dilutions: |
WB(1:100-1000) |
| Crossreactivity: |
Human |
| Crossreactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Antigen background: |
Activity of CDK2 is maximal during S phase and G2, Acts at the G1-S transition to promote the E2F transcriptional program and the initiation of DNA synthesis, B1, B3, BRCA2, CDK7, Crucial role in orchestrating a fine balance between cellular proliferation, Cyclin E/CDK2 prevents oxidative stress-mediated Ras-induced senescence by phosphorylating MYC, D, EZH2, EZH2 phosphorylation promotes H3K27me3 maintenance and epigenetic gene silencing, In response to DNA damage, Interacts with cyclins A, Involved in G1-S phase DNA damage checkpoint that prevents cells with damaged DNA from initiating mitosis, MYC, NPAT, NPM1, NPM1 phosphorylation by cyclin E/CDK2 promotes its dissociates from unduplicated centrosomes, Phosphorylates CABLES1 (By similarity), Phosphorylates CTNNB1, Phosphorylation of RB1 disturbs its interaction with E2F1, RB1, Triggers duplication of centrosomes and DNA, USP37, activated by interaction with cyclin E during the early stages of DNA synthesis to permit G1-S transition, and DNA repair in human embryonic stem cells (hESCs), and coordinates the activation of cyclin B/CDK1 at the centrosome and in the nucleus, and modulates G2 progression, and subsequently activated by cyclin A2 (cyclin A1 in germ cells) during the late stages of DNA replication to drive the transition from S phase to mitosis, but dispensable for mitosis, but increases as cells progress towards mitosis, cell death, controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, double-strand break repair by homologous recombination a reduction of CDK2-mediated BRCA2 phosphorylation, essential for meiosis, or E, p53/TP53, regulates homologous recombination-dependent repair by phosphorylating BRCA2, the G2 phase, this phosphorylation is low in S phase when recombination is active, thus initiating centrosome duplication, Serine/threonine-protein kinase involved in the control of the cell cycle |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% Gentamicin, Keep the antibody in an aqueous buffered solution containing 1% BSA |
| Properties: |
Also monoclonal HRP conjugates are often used for Western Blot, HRP conjugates are often primary rabbit polyclonal antibodies couples to the , found in the roots of , (HRP), C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°, enzyme , horseradish, horseradish peroxidase |
| Gene target: |
CDK2 Conjugated |
| Short name: |
Conjugated, CDK2 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, antibody Conjugates, Antibody |
| Label: |
HRP |
| Alternative name: |
horseradish peroxidase coupled, CDK2 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
1771 |
| Gene: |
CDK2 |
More about : CDK2 |
| Long gene name: |
cyclin dependent kinase 2 |
| Locus: |
12q13, 2 |
| Discovery year: |
1992-02-28 |
| GenBank acession: |
M68520 |
| Entrez gene record: |
1017 |
| Pubmed identfication: |
1717994 8275715 |
| Classification: |
Cyclin dependent kinases |
| Havana BLAST/BLAT: |
OTTHUMG00000170575 |