IRAK4(Thr345) Antibody , ALEXA FLUOR 350

Catalog number:	bs-10208R-A350 Buy Now
Price:	332 €
Supplier:	Bioss Primary Conjugated Antibodies.
Product name:	IRAK4(Thr345) Antibody , ALEXA FLUOR 350
Quantity:	100ul
Related search:	process receptor protein binding pathway function antibody interleukin irakthr transferase serinethreonine

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Long name:	ALEXA FLUOR 350 Conjugated, IRAK4(Thr345) Polyclonal Antibody
Also known as:	Anti-IRAK4(Thr345) PAb ALEXA FLUOR 350
Category:	Conjugated Primary Antibodies
Conjugated with:	350, ALEXA FLUOR®
Host Organism:	Rabbit (Oryctolagus cuniculus)
Target Antigen:	IRAK4(Thr345)
Specificity:	This is a highly specific antibody against IRAK4(Thr345)
Modification:	Phosphorylation
Modification Site:	Thr345
Clonality:	Polyclonal
Clone:	Polyclonal antibody
Concentration:	1ug per 1ul
Immunogen range:	330-360/460
Subcellular location:	Cytoplasm
Source:	KLH conjugated Synthesised phosphopeptide derived from human IRAK4 around the phosphorylation site of Thr345
Gene ID Number:	51135
Swiss Prot:	Q9NWZ3
Tested applications:	IF(IHC-P)
Recommended dilutions:	IF(IHC-P)(1:50-200)
Crossreactivity:	Human
Cross-reactive species details:	not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the antigen:	Alternatively, In turn, Involved in Toll-like receptor (TLR) and IL-1R signaling pathways, Is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation to form the Myddosome together with IRAK2, MAP3K7/TAK1 activates IKKs (CHUK/IKKA and IKBKB/IKKB) leading to NF-kappa-B nuclear translocation and activation, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1, Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, Phosphorylates NCF1 and regulates NADPH oxidase activation after LPS stimulation suggesting a similar mechanism during microbial infections, Phosphorylates initially IRAK1, Then, phosphorylates TIRAP to promote its ubiquitination and subsequent degradation, the ubiquitin-binding domain of IKBKG/NEMO binds to polyubiquitinated IRAK1 bringing together the IRAK1-MAP3K7/TAK1-TRAF6 complex and the NEMO-IKKA-IKKB complex, thus stimulating the kinase activity and intensive autophosphorylation of IRAK1, Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens
Purification:	Purified by Protein A
Storage conditions:	50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA
Excitation emission:	343nm/442nm
Synonyms:	NY-REN-64
Properties:	ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 350 conjugates can be used in multi-color flow cytometry with FACS's equipped with a second red laser or red diode, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate
Conjugation:	ALEXA FLUOR 350, Alexa Fluor
Gene target:	IRAK4(Thr345)
Short name:	IRAK4(Thr345) Antibody
Technique:	antibodies against human proteins, antibodies for, Antibody
Label:	ALEXA FLUOR 350
Alternative name:	ALEXA FLUOR 350, interleukin-1 receptor-associated kinase 4(Thr345) (Antibody to)
Alternative technique:	antibodies
Alternative to gene target:	Extracellular, IRAK4 and IDBG-28022 and ENSG00000198001 and 51135, IRAK4 and IDBG-633310 and ENSBTAG00000021105 and 533692, Irak4 and IDBG-177236 and ENSMUSG00000059883 and 266632, this GO :0000287 and magnesium ion binding and molecular function this GO :0001816 and cytokine production and biological process this GO :0002224 and toll-like receptor signaling pathway and biological process this GO :0002755 and MyD88-dependent toll-like receptor signaling pathway and biological process this GO :0004672 and protein kinase activity and molecular function this GO :0004674 and protein serine/threonine kinase activity and molecular function this GO :0004713 and protein tyrosine kinase activity and molecular function this GO :0005149 and interleukin-1 receptor binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005524 and ATP binding and molecular function this GO :0005615 and extracellular space and cellular component this GO :0005829 and cytosol and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0006468 and protein phosphorylation and biological process this GO :0007165 and signal transduction and biological process this GO :0007254 and JNK cascade and biological process this GO :0010008 and endosome membrane and cellular component this GO :0016772 and transferase activity, this GO :0000287 : magnesium ion binding, this GO :0000287 : magnesium ion binding and also this GO :0004672 : protein kinase activity and also this GO :0004674 : protein serine/threonine kinase activity and also this GO :0004713 : protein tyrosine kinase activity and also this GO :0005149 : interleukin-1 receptor binding and also this GO :0005515 : protein binding and also this GO :0005524 : ATP binding and also this GO :0016772 : transferase activity, this GO :0004672 : protein kinase activity, this GO :0004674 : protein serine/threonine kinase activity, this GO :0004713 : protein tyrosine kinase activity, this GO :0005149 : interleukin-1 receptor binding, this GO :0005515 : protein binding, this GO :0005524 : ATP binding, this GO :0016772 : transferase activity, transferase activity, transferring phosphorus-containing groups, transferring phosphorus-containing groups, transferring phosphorus-containing groups and molecular function this GO :0019221 and cytokine-mediated signaling pathway and biological process this GO :0034134 and toll-like receptor 2 signaling pathway and biological process this GO :0034142 and toll-like receptor 4 signaling pathway and biological process this GO :0034146 and toll-like receptor 5 signaling pathway and biological process this GO :0034162 and toll-like receptor 9 signaling pathway and biological process this GO :0034166 and toll-like receptor 10 signaling pathway and biological process this GO :0038123 and toll-like receptor TLR1:TLR2 signaling pathway and biological process this GO :0038124 and toll-like receptor TLR6:TLR2 signaling pathway and biological process this GO :0043123 and positive regulation of I-kappaB kinase/NF-kappaB signaling and biological process this GO :0045087 and innate immune response and biological process this GO :0048661 and positive regulation of smooth muscle cell proliferation and biological process, interleukin-1 receptor-associated kinase 4
Identity:	17967
Gene:	IRAK4 | More about : IRAK4
Long gene name:	interleukin 1 receptor associated kinase 4
Locus:	12q12
Discovery year:	2002-09-27
GenBank acession:	AF155118
Entrez gene record:	51135
Pubmed identfication:	3772297 10508479
Havana BLAST/BLAT:	OTTHUMG00000169425
Locus Specific Databases:	IRAK4base: Mutation registry for IRAK4 deficiency LRG_75

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