| Long name: |
IRAK1 (Thr209) Primary Polyclonal Antibody |
| Also known as: |
IRAK1 (Thr209) PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
IRAK1 Thr209 |
| Specificity: |
This is a highly specific antibody against IRAK1 Thr209 |
| Modification(s): |
Phosphorylation |
| Modification site(s): |
Thr209 |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
195-225/710 |
| Subcellular location: |
Nucleus, Cytoplasm |
| Source: |
KLH conjugated synthetic phosphopeptide derived from mouse IRAK1 around the phosphorylation site of Thr209 [QG(p-T)CN] |
| Gene ID number: |
16179 |
| Swiss Prot: |
Q62406 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Rat, Mouse |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Alternatively, Association with MYD88 leads to IRAK1 phosphorylation by IRAK4 and subsequent autophosphorylation and kinase activation, In turn, Involved in Toll-like receptor (TLR) and IL-1R signaling pathways, Is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation, MAP3K7/TAK1 activates IKKs (CHUK/IKKA and IKBKB/IKKB) leading to NF-kappa-B nuclear translocation and activation, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1, Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, Phosphorylates the interferon regulatory factor 7 (IRF7) to induce its activation and translocation to the nucleus, Then, When sumoylated, phosphorylates TIRAP to promote its ubiquitination and subsequent degradation, resulting in transcriptional activation of type I IFN genes, the ubiquitin-binding domain of IKBKG/NEMO binds to polyubiquitinated IRAK1 bringing together the IRAK1-MAP3K7/TAK1-TRAF6 complex and the NEMO-IKKA-IKKB complex, translocates to the nucleus and phosphorylates STAT3 (By similarity), which drive the cell in an antiviral state, Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
AA48924, IRAK-1, IRAK1-S, Il1rak, Interleukin-1 receptor-associated kinase 1, Irak1, Pelle-like protein kinase, Plpk, mPLK, IRAK |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
IRAK1 (Thr209) |
| Short name: |
IRAK1 (Thr209) Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
interleukin-1 receptor-associated kinase 1 (Thr209) (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
DNA-templated and biological process this GO :0046777 and protein autophosphorylation and biological process this GO :0046982 and protein heterodimerization activity and molecular function this GO :0048011 and neurotrophin TRK receptor signaling pathway and biological process this GO :0048661 and positive regulation of smooth muscle cell proliferation and biological process this GO :0051092 and positive regulation of NF-kappaB transcription factor activity and biological process this GO :0051259 and protein oli this GO merization and biological process this GO :0051403 and stress-activated MAPK cascade and biological process this GO :0070423 and nucleotide-binding oli this GO merization domain containing signaling pathway and biological process this GO :0070498 and interleukin-1-mediated signaling pathway and biological process this GO :0070555 and response to interleukin-1 and biological process this GO :0071222 and cellular response to lipopolysaccharide and biological process this GO :0071456 and cellular response to hypoxia and biological process, IRAK and pelle, IRAK1 and IDBG-632573 and ENSBTAG00000016085 and 533953, IRAK1 and IDBG-90782 and ENSG00000184216 and 3654, Irak1 and IDBG-154747 and ENSMUSG00000031392 and 16179, leucine rich repeat containing receptor signaling pathway and biological process this GO :0038123 and toll-like receptor TLR1:TLR2 signaling pathway and biological process this GO :0038124 and toll-like receptor TLR6:TLR2 signaling pathway and biological process this GO :0042803 and protein homodimerization activity and molecular function this GO :0043066 and negative regulation of apoptotic process and biological process this GO :0043123 and positive regulation of I-kappaB kinase/NF-kappaB signaling and biological process this GO :0045087 and innate immune response and biological process this GO :0045323 and interleukin-1 receptor complex and cellular component this GO :0045893 and positive regulation of transcription, nuclei, this GO :0000187 and activation of MAPK activity and biological process this GO :0001959 and regulation of cytokine-mediated signaling pathway and biological process this GO :0002224 and toll-like receptor signaling pathway and biological process this GO :0002755 and MyD88-dependent toll-like receptor signaling pathway and biological process this GO :0002756 and MyD88-independent toll-like receptor signaling pathway and biological process this GO :0004672 and protein kinase activity and molecular function this GO :0004674 and protein serine/threonine kinase activity and molecular function this GO :0004704 and NF-kappaB-inducing kinase activity and molecular function this GO :0004713 and protein tyrosine kinase activity and molecular function this GO :0004842 and ubiquitin-protein transferase activity and molecular function this GO :0005149 and interleukin-1 receptor binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005524 and ATP binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005811 and lipid particle and cellular component this GO :0005829 and cytosol and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0006468 and protein phosphorylation and biological process this GO :0007165 and signal transduction and biological process this GO :0007178 and transmembrane receptor protein serine/threonine kinase signaling pathway and biological process this GO :0007250 and activation of NF-kappaB-inducing kinase activity and biological process this GO :0007254 and JNK cascade and biological process this GO :0007568 and aging and biological process this GO :0008152 and metabolic process and biological process this GO :0010008 and endosome membrane and cellular component this GO :0016020 and membrane and cellular component this GO :0016301 and kinase activity and molecular function this GO :0016567 and protein ubiquitination and biological process this GO :0016772 and transferase activity, this GO :0004672 : protein kinase activity, this GO :0004672 : protein kinase activity and also this GO :0004674 : protein serine/threonine kinase activity and also this GO :0004704 : NF-kappaB-inducing kinase activity and also this GO :0004713 : protein tyrosine kinase activity and also this GO :0004842 : ubiquitin-protein transferase activity and also this GO :0005149 : interleukin-1 receptor binding and also this GO :0005515 : protein binding and also this GO :0005524 : ATP binding and also this GO :0016301 : kinase activity and also this GO :0016772 : transferase activity, this GO :0004674 : protein serine/threonine kinase activity, this GO :0004704 : NF-kappaB-inducing kinase activity, this GO :0004713 : protein tyrosine kinase activity, this GO :0004842 : ubiquitin-protein transferase activity, this GO :0005149 : interleukin-1 receptor binding, this GO :0005515 : protein binding, this GO :0005524 : ATP binding, this GO :0016301 : kinase activity, this GO :0016772 : transferase activity, this GO :0031072 : heat shock protein binding, this GO :0042803 : protein homodimerization activity, this GO :0046982 : protein heterodimerization activity, transferase activity, transferring phosphorus-containing groups, transferring phosphorus-containing groups and also this GO :0031072 : heat shock protein binding and also this GO :0042803 : protein homodimerization activity and also this GO :0046982 : protein heterodimerization activity, transferring phosphorus-containing groups and molecular function this GO :0019221 and cytokine-mediated signaling pathway and biological process this GO :0031072 and heat shock protein binding and molecular function this GO :0031663 and lipopolysaccharide-mediated signaling pathway and biological process this GO :0032088 and negative regulation of NF-kappaB transcription factor activity and biological process this GO :0032494 and response to peptidoglycan and biological process this GO :0032496 and response to lipopolysaccharide and biological process this GO :0034134 and toll-like receptor 2 signaling pathway and biological process this GO :0034138 and toll-like receptor 3 signaling pathway and biological process this GO :0034142 and toll-like receptor 4 signaling pathway and biological process this GO :0034146 and toll-like receptor 5 signaling pathway and biological process this GO :0034162 and toll-like receptor 9 signaling pathway and biological process this GO :0034166 and toll-like receptor 10 signaling pathway and biological process this GO :0034605 and cellular response to heat and biological process this GO :0035666 and TRIF-dependent toll-like receptor signaling pathway and biological process this GO :0035872 and nucleotide-binding domain, interleukin-1 receptor-associated kinase 1 |
| Identity: |
6112 |
| Gene: |
IRAK1 |
More about : IRAK1 |
| Long gene name: |
interleukin 1 receptor associated kinase 1 |
| Synonyms: |
IRAK pelle |
| Locus: |
Xq28 |
| Discovery year: |
1998-06-22 |
| GenBank acession: |
L76191 |
| Entrez gene record: |
3654 |
| Pubmed identfication: |
9374458 8599092 |
| Havana BLAST/BLAT: |
OTTHUMG00000024228 |
| Locus Specific Databases: |
Mental Retardation database |