| Long name: |
ALEXA FLUOR 594 Conjugated, CXCR4 Polyclonal Antibody |
| Also known as: |
Anti-CXCR4 PAb ALEXA FLUOR 594 |
| Category: |
Conjugated Primary Antibodies |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
CXCR4 |
| Specificity: |
This is a highly specific antibody against CXCR4 |
| Modification: |
Unmodified |
| Modification Site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
217-241/352 |
| Subcellular location: |
Cytoplasm |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human CXCR4 |
| Gene ID Number: |
7852 |
| Tested applications: |
IF(IHC-P), FCM |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), FCM(1:20-100) |
| Crossreactivity: |
Mouse, Rat, Human |
| Cross-reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the antigen: |
Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 X4 isolates and as a primary receptor for some HIV-2 isolates, Acts as a receptor for extracellular ubiquitin, Also plays an essential role in vascularization of the gastrointestinal tract, Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, In the CNS, Involved in cerebellar development, Involved in hematopoiesis and in cardiac ventricular septum formation, Promotes Env-mediated fusion of the virus, could mediate hippocampal-neuron survival, including TNF secretion by monocytes, leading to enhanced intracellular calcium ions and reduced cellular cAMP levels, probably by regulating vascular branching and/or remodeling processes in endothelial cells, Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation |
| Purification: |
Purified by Protein A |
| Storage conditions: |
50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
LESTR NPY3R HM89 NPYY3R D2S201E fusin HSY3RR NPYR CD184 |
| Properties: |
ALEXA FLUOR they should be stored frozen at - 24°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
594, ALEXA FLUOR®, Alexa Fluor |
| Conjugated: |
Alexa conjugate 1 |
| Gene target: |
CXCR4 |
| Short name: |
CXCR4 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Label: |
ALEXA FLUOR 594 |
| Alternative name: |
ALEXA FLUOR 594, chemokine (C-X-C motif) receptor 4 (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
CD184 and D2S201E and FB22 and HM89 and HSY3RR and LAP-3 and LAP3 and LCR1 and LESTR and NPY3R and NPYR and NPYRL and NPYY3R and WHIM, CXCR4 and IDBG-642187 and ENSBTAG00000001060 and 281736, CXCR4 and IDBG-71032 and ENSG00000121966 and 7852, Cell surfaces, Cxcr4 and IDBG-189999 and ENSMUSG00000045382 and 12767, this GO :0000187 and activation of MAPK activity and biological process this GO :0001569 and patterning of blood vessels and biological process this GO :0001618 and virus receptor activity and molecular function this GO :0001666 and response to hypoxia and biological process this GO :0001667 and ameboidal cell migration and biological process this GO :0001764 and neuron migration and biological process this GO :0002407 and dendritic cell chemotaxis and biological process this GO :0003779 and actin binding and molecular function this GO :0004930 and G-protein coupled receptor activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005737 and cytoplasm and cellular component this GO :0005764 and lysosome and cellular component this GO :0005769 and early endosome and cellular component this GO :0005770 and late endosome and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0005911 and cell-cell junction and cellular component this GO :0006915 and apoptotic process and biological process this GO :0006954 and inflammatory response and biological process this GO :0007186 and G-protein coupled receptor signaling pathway and biological process this GO :0007204 and positive regulation of cytosolic calcium ion concentration and biological process this GO :0007281 and germ cell development and biological process this GO :0007420 and brain development and biological process this GO :0008045 and motor neuron axon guidance and biological process this GO :0008354 and germ cell migration and biological process this GO :0009615 and response to virus and biological process this GO :0009897 and external side of plasma membrane and cellular component this GO :0009986 and cell surface and cellular component this GO :0015026 and coreceptor activity and molecular function this GO :0016021 and integral component of membrane and cellular component this GO :0016023 and cytoplasmic membrane-bounded vesicle and cellular component this GO :0016032 and viral process and biological process this GO :0016494 and C-X-C chemokine receptor activity and molecular function this GO :0019722 and calcium-mediated signaling and biological process this GO :0019955 and cytokine binding and molecular function this GO :0030054 and cell junction and cellular component this GO :0030260 and entry into host cell and biological process this GO :0030334 and regulation of cell migration and biological process this GO :0030426 and growth cone and cellular component this GO :0031252 and cell leading edge and cellular component this GO :0031410 and cytoplasmic vesicle and cellular component this GO :0031625 and ubiquitin protein ligase binding and molecular function this GO :0032027 and myosin light chain binding and molecular function this GO :0042098 and T cell proliferation and biological process this GO :0042119 and neutrophil activation and biological process this GO :0043130 and ubiquitin binding and molecular function this GO :0043217 and myelin maintenance and biological process this GO :0045087 and innate immune response and biological process this GO :0048699 and generation of neurons and biological process this GO :0048714 and positive regulation of oli this GO dendrocyte differentiation and biological process this GO :0050920 and regulation of chemotaxis and biological process this GO :0061351 and neural precursor cell proliferation and biological process this GO :0070062 and extracellular vesicular exosome and cellular component this GO :0070098 and chemokine-mediated signaling pathway and biological process this GO :0071345 and cellular response to cytokine stimulus and biological process, this GO :0001618 : virus receptor activity, this GO :0001618 : virus receptor activity and also this GO :0003779 : actin binding and also this GO :0004930 : G-protein coupled receptor activity and also this GO :0005515 : protein binding and also this GO :0015026 : coreceptor activity and also this GO :0016494 : C-X-C chemokine receptor activity and also this GO :0019955 : cytokine binding and also this GO :0031625 : ubiquitin protein ligase binding and also this GO :0032027 : myosin light chain binding and also this GO :0043130 : ubiquitin binding, this GO :0003779 : actin binding, this GO :0004930 : G-protein coupled receptor activity, this GO :0005515 : protein binding, this GO :0015026 : coreceptor activity, this GO :0016494 : C-X-C chemokine receptor activity, this GO :0019955 : cytokine binding, this GO :0031625 : ubiquitin protein ligase binding, this GO :0032027 : myosin light chain binding, this GO :0043130 : ubiquitin binding, ubiquitin binding, chemokine (C-X-C motif) receptor 4 |
| Identity: |
2561 |
| Gene: |
CXCR4 |
More about : CXCR4 |
| Long gene name: |
C-X-C motif chemokine receptor 4 |
| Synonyms gene name: |
chemokine (C-X-C motif), receptor 4 (fusin) chemokine (C-X-C motif) receptor 4 |
| Locus: |
2q22, 1 |
| Discovery year: |
1998-09-17 |
| GenBank acession: |
AF005058 |
| Entrez gene record: |
7852 |
| Pubmed identfication: |
9599023 9379028 |
| Classification: |
CD molecules C-X-C motif chemokine receptors |
| Havana BLAST/BLAT: |
OTTHUMG00000153583 |
| Locus Specific Databases: |
CXCR4base: Mutation registry for WHIM syndrome (warts, and myelokathexis) LRG_51 , hypogammaglobulinemia, immunodeficiency |