| Long name: |
Acetyl-p53(K382) Primary Polyclonal Antibody |
| Also known as: |
Acetyl-p53(K382) PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
Acetyl-p53 K382 |
| Specificity: |
This is a highly specific antibody against Acetyl-p53 K382 |
| Modification(s): |
Acetylation |
| Modification site(s): |
K382 |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
350-393/393 |
| Subcellular location: |
Nucleus, Cytoplasm |
| Source: |
KLH conjugated synthetic acetylpeptide derived from human p53 around acetylation site of K382 |
| Gene ID number: |
7157 |
| Swiss Prot: |
P04637 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, Implicated in Notch signaling cross-over, In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis, Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1, Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process, Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters, Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1, Isoform 7 inhibits isoform 1-mediated apoptosis, LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seem to have to effect on cell-cycle regulation, One of the activated genes is an inhibitor of cyclin-dependent kinases, Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, induces growth arrest or apoptosis depending on the physiological circumstances and cell type, or by repression of Bcl-2 expression, the function is largely independent of transcription, thus stopping cell cycle progression, Acts as a tumor suppressor in many tumor types |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
Antigen NY-CO-13, BCC7, Cellular tumor antigen p53, LFS1, Phosphoprotein p53, TP53, TRP53, Tumor suppressor p53, P53 |
| Description: |
N terminal acetylation or CH3CO as epigenetic regulation of -p53(K382) Antibody by NATs |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
p53(K382) |
| Short name: |
-p53(K382) Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
Acetyl-p53(K382) (Antibody to) |
| Alternative technique: |
antibodies |