| Long name: |
IFN-beta Primary Polyclonal Antibody |
| Also known as: |
IFN-beta PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
IFN-beta |
| Specificity: |
This is a highly specific antibody against IFN-beta |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
KLH conjugated synthetic peptide derived from mouse IFN-beta |
| Gene ID number: |
24481 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Rat, Mouse |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Both IFN subtypes are pleiotropic cytokines and have a similar range of biological activities, Both chains are necessary for function and in the absence of either there is neither high affinity binding nor biological activity, Differences between alpha subtypes, Higher potency of IFN beta in treatment of multiple sclerosis and certain cancers has been observed, IFN beta elicits a markedly higher antiproliferation response in some cell types such as, IFNAR1 and IFNAR2, In particular, Jak1 and Tyk2, The human IFN alphas are encoded by a family of at least 15 different genes, The intracellular portions of the receptor subunits are bound by tyrosine kinases, There is approximately 50% amino acid homology between the alpha and beta subtypes, They are divided into alpha and beta subtypes leukocytes and fibroblasts reactivity, Two chains of the receptor, Type I IFNs signal through binding to a common cell surface receptor, Upon ligand binding these kinases are activated and phosphorylate members of the STAT family of transcription factors, and between IFN alpha and betas, are in potency and cell type specific activities, as well as IFNAR1 and 2, embryonal carcinoma, have been identified, melanoma and melanocytes than do IFN alphas, members of the Janus kinase family, while IFN beta is the unique member of its subtype, The mammalian type I Inteferons (IFN1) are produced in response to viral infection and other inducers |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
Î, Î, Î, B, Beta N, Beta-N, F, Interferon beta 1 fibroblast , Interferon beta precursor, Interferon betaï, Interferon-beta, MGC96956ï, N, N Î, N beta, N-Beta, NB , NB 1, NB1, ¼, ¼, &rsaquo, &rsaquo, ², ², ², ², -N, Fibroblast interferon, N |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
IFN-beta |
| Short name: |
IFN-beta Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
Interferon-b (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
5417 |
| Gene: |
IFNA1 |
More about : IFNA1 |
| Long gene name: |
interferon alpha 1 |
| Synonyms: |
IFNA@ IFL IFN IFN-ALPHA IFNA13 IFN-alphaD |
| Synonyms name: |
IFN-alpha 1b interferon alpha 1b |
| Locus: |
9p21, 3 |
| Discovery year: |
1993-01-14 |
| Entrez gene record: |
3439 |
| Pubmed identfication: |
1385305 |
| RefSeq identity: |
NM_024013 |
| Classification: |
Interferons |
| Havana BLAST/BLAT: |
OTTHUMG00000019673 |