| Long name: |
ALEXA FLUOR 488 Conjugated, Dnmt1 Polyclonal Antibody |
| Also known as: |
Anti-Dnmt1 PAb ALEXA FLUOR 488 |
| Category: |
Conjugated Primary Antibodies |
| Conjugated with: |
488, ALEXA FLUOR® |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
Dnmt1 |
| Specificity: |
This is a highly specific antibody against Dnmt1 |
| Modification: |
Unmodified |
| Modification Site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
10-60/1616 |
| Subcellular location: |
Nucleus |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Dnmt1 |
| Gene ID Number: |
1786 |
| Swiss Prot: |
P26358 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Cross-reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the antigen: |
Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication, DNA methylation is coordinated with methylation of histones, In association with DNMT3B and via the recruitment of CTCFL/BORIS, It is responsible for maintaining methylation patterns established in development, Mediates transcriptional repression by direct binding to HDAC2, Preferentially methylates hemimethylated DNA, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9, that is essential for epigenetic inheritance, Methylates CpG residues |
| Purification: |
Purified by Protein A |
| Storage conditions: |
50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA |
| Excitation emission: |
499nm/519nm |
| Synonyms: |
MCMT CXXC9 DNMT1 |
| Properties: |
ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 488 has the same range to that of fluorescein isothiocyanate (FITC), Also Alexa Fluor 488 is pH stable, As a result of this photo stability, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, It is distinguished in the FL1 of a FACS-Calibur or FACScan, has a very high photo stability, it has turned into an antibody for fluorescent microscopy and FACS FLOW cytometry, yet the Dnmt1 Antibody, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Gene target: |
Dnmt1 |
| Short name: |
Dnmt1 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Label: |
ALEXA FLUOR 488 |
| Alternative name: |
ALEXA FLUOR 488, Dnmt1 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
2975 |
| Gene: |
DNMT |
More about : DNMT |
| Long gene name: |
DNA methyltransferase 1 |
| Synonyms gene name: |
DNA (cytosine-5-)-methyltransferase 1 |
| Locus: |
19p13, 2 |
| Discovery year: |
1991-06-04 |
| GenBank acession: |
X63692 |
| Entrez gene record: |
1786 |
| Pubmed identfication: |
1594447 |
| RefSeq identity: |
NM_001379 |
| Classification: |
Zinc fingers CXXC-type |
| Havana BLAST/BLAT: |
OTTHUMG00000180397 |
| Locus Specific Databases: |
LRG_362 |