| Long name: |
DCC Primary Polyclonal Antibody |
| Also known as: |
DCC PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
DCC |
| Specificity: |
This is a highly specific antibody against DCC |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human DCC |
| Gene ID number: |
1630 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
DCC functions as a receptor or a component of a receptor for netrins and mediates the effects of netrins on commissural axons, DCC induces apoptosis in the absence of ligand binding, DCC is highly expressed in the brain but is also expressed at very low levels in multiple normal tissues, In adults, In the embyro, Mouse DCC extracellular domain shares 97% and 99% homology with human and rat DCC extracellular domains, Native DCC is found in three isoforms, Netrins are chemoattractants responsible for the guidance of commissural axons at the midline and of motor axons to the their target muscles, The DCC protein is a type I transmembrane glycoprotein that belongs to the immunoglobulin (Ig) superfamily, The extracellular domain is composed of four Ig like domains and six fibronectin type III repeats, The gene has also been deleted in several other types of cancer, The third isoform, Two forms, a long and a short isoform, and also acts as a caspase substrate, are produced from the same gene but have different initiation sites, blocks apoptosis when engaged by netrin 1, chromosome 18q21) was originally identified as a putative tumor suppressor gene that is lost in more than 70% of colorectal cancers, high levels of expression are detected in the brain and neural tube, is expressed only in embryonic tissue, produced by alternative splicing, respectively, Deleted in colorectal cancer (DCC |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
CRC 18, CRC18, CRCR, CRCR 1, Colorectal cancer related chromosome sequence 18, Colorectal cancer suppressor, DCC_RAT, Deleted in colorectal cancer protein, Deleted in colorectal carcinoma, Igdcc1, Immunoglobulin domain cell adhesion molecule, Netrin receptor DCC, Tumor suppressor protein DCC, Deleted in Colorectal Cancer |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
DCC |
| Short name: |
DCC Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
deleted in colorectal carcinoma (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
CRC18 and CRCR1 and IGDCC1 and MRMV1 and NTN1R1, DCC and IDBG-3511 and ENSG00000187323 and 1630, Dcc and IDBG-157336 and ENSMUSG00000060534 and 13176, Plasma membranes, identical protein binding, this GO :0001764 and neuron migration and biological process this GO :0001975 and response to amphetamine and biological process this GO :0003713 and transcription coactivator activity and molecular function this GO :0004888 and transmembrane signaling receptor activity and molecular function this GO :0005042 and netrin receptor activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005829 and cytosol and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0006915 and apoptotic process and biological process this GO :0007409 and axonogenesis and biological process this GO :0007411 and axon guidance and biological process this GO :0010976 and positive regulation of neuron projection development and biological process this GO :0010977 and negative regulation of neuron projection development and biological process this GO :0016021 and integral component of membrane and cellular component this GO :0021965 and spinal cord ventral commissure morphogenesis and biological process this GO :0030424 and axon and cellular component this GO :0032584 and growth cone membrane and cellular component this GO :0033563 and dorsal/ventral axon guidance and biological process this GO :0033564 and anterior/posterior axon guidance and biological process this GO :0038007 and netrin-activated signaling pathway and biological process this GO :0042802 and identical protein binding and molecular function this GO :0042981 and regulation of apoptotic process and biological process this GO :0043065 and positive regulation of apoptotic process and biological process this GO :0045121 and membrane raft and cellular component this GO :0048671 and negative regulation of collateral sprouting and biological process this GO :0070374 and positive regulation of ERK1 and ERK2 cascade and biological process this GO :2000171 and negative regulation of dendrite development and biological process this GO :2001141 and regulation of RNA biosynthetic process and biological process, this GO :0003713 : transcription coactivator activity, this GO :0003713 : transcription coactivator activity and also this GO :0004888 : transmembrane signaling receptor activity and also this GO :0005042 : netrin receptor activity and also this GO :0005515 : protein binding and also this GO :0042802 : identical protein binding, this GO :0004888 : transmembrane signaling receptor activity, this GO :0005042 : netrin receptor activity, this GO :0005515 : protein binding, this GO :0042802 : identical protein binding, deleted in colorectal carcinoma |
| Identity: |
2701 |
| Gene: |
DCC |
More about : DCC |
| Long gene name: |
DCC netrin 1 receptor |
| Synonyms gene name: |
deleted in colorectal carcinoma |
| Synonyms: |
IGDCC1 NTN1R1 |
| Synonyms name: |
DCC subclass, immunoglobulin superfamily, member 1 |
| Locus: |
18q21, 2 |
| Discovery year: |
1990-05-25 |
| GenBank acession: |
X76132 |
| Entrez gene record: |
1630 |
| Pubmed identfication: |
2294591 24400119 |
| RefSeq identity: |
NM_005215 |
| Classification: |
I-set domain containing Immunoglobulin like domain containing Fibronectin type III domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000132698 |
| Locus Specific Databases: |
LRG_1107 |