| Long name: |
PALB2 Primary Polyclonal Antibody |
| Also known as: |
PALB2 PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
PALB2 |
| Specificity: |
This is a highly specific antibody against PALB2 |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
1100-1150/1186 |
| Subcellular location: |
Nucleus |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human PALB2 |
| Gene ID number: |
79728 |
| Swiss Prot: |
Q86YC2 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Also enables its recombinational repair and checkpoint functions of BRCA2, Binds DNA with high affinity for D loop, Essential partner of BRCA2 that promotes the localization and stability of BRCA2, Functionally cooperates with RAD51AP1 in promoting of D-loop formation by RAD51, May act by promoting stable association of BRCA2 with nuclear structures, May play a role in the extension step after strand invasion at replication-dependent DNA double-strand breaks, Serves as the molecular scaffold in the formation of the BRCA1-PALB2-BRCA2 complex which is essential for homologous recombination, Strongly stimulates the DNA strand-invasion activity of RAD51, Via its WD repeats is proposed to scaffold a HR complex containing RAD51C and BRCA2 which is thought to play a role in HR-mediated DNA repair, allowing BRCA2 to escape the effects of proteasome-mediated degradation, double-stranded and branched DNA structures, stabilizes the nucleoprotein filament against a disruptive BRC3-BRC4 polypeptide and helps RAD51 to overcome the suppressive effect of replication protein A (RPA), together with BRCA2 is involved in both POLH localization at collapsed replication forks and DNA polymerization activity, which comprises single-stranded, Plays a critical role in homologous recombination repair (HRR) through its ability to recruit BRCA2 and RAD51 to DNA breaks |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
PALB2, PNCA3, Partner and localizer of BRCA2, FANCN |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
PALB2 |
| Short name: |
PALB2 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
PALB2 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
26144 |
| Gene: |
PALB2 |
More about : PALB2 |
| Long gene name: |
partner and localizer of BRCA2 |
| Synonyms: |
FLJ21816 FANCN |
| Synonyms name: |
Fanconi anemia, complementation group N |
| Locus: |
16p12, 2 |
| Discovery year: |
2007-01-15 |
| Entrez gene record: |
79728 |
| Pubmed identfication: |
16793542 17200672 |
| RefSeq identity: |
NM_024675 |
| Classification: |
Fanconi anemia complementation groups |
| Havana BLAST/BLAT: |
OTTHUMG00000177097 |
| Locus Specific Databases: |
Fanconi anemia database LRG_308 |