| Long name: |
GABABR1 Primary Polyclonal Antibody |
| Also known as: |
GABABR1 PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
GABABR1 |
| Specificity: |
This is a highly specific antibody against GABABR1 |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
670-720/961 |
| Subcellular location: |
Cytoplasm |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human GABABR1 |
| Gene ID number: |
2550 |
| Swiss Prot: |
Q9UBS5 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Activated by (-)-baclofen, Calcium is required for high affinity binding to GABA, Isoform 1E may regulate the formation of functional GABBR1/GABBR2 heterodimers by competing for GABBR2 binding, Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, Plays a critical role in the fine-tuning of inhibitory synaptic transmission, Pre-synaptic GABA receptor inhibits neurotransmitter release by down-regulating high-voltage activated calcium channels, Signaling inhibits adenylate cyclase, This could explain the observation that certain small molecule ligands exhibit differential affinity for central versus peripheral sites, Within the heterodimeric GABA receptor, activates potassium channels, cgp27492 and blocked by phaclofen, formed by GABBR1 and GABBR2, inactivates voltage-dependent calcium-channels and modulates inositol phospholipid hydrolysis, muscle relaxation and antinociception, only GABBR1 seems to bind agonists, slow wave sleep, stimulates phospholipase A2, such as adenylate cyclase, whereas postsynaptic GABA receptor decreases neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials, while GABBR2 mediates coupling to G proteins, Component of a heterodimeric G-protein coupled receptor for GABA |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
GABA-B receptor 1, GABA-B-R1, GABA-BR1, GABABR1, GABBR1, GABBR1-3, GPRC3A, Gamma-aminobutyric acid type B receptor subunit 1, dJ271M21, dJ271M21, 1, 1, 1, 2, GB1 |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
GABABR1 |
| Short name: |
GABABR1 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
GABABR1 (Antibody to) |
| Alternative technique: |
antibodies |