| Long name: |
PHD3 Primary Polyclonal Antibody |
| Also known as: |
PHD3 PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
PHD3 |
| Specificity: |
This is a highly specific antibody against PHD3 |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
KLH conjugated synthetic peptide derived from PHD3 |
| Gene ID number: |
112399 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Egln3, Expressed athigher levels in heart (cardiac myocytes, Functions as a cellular oxygen sensor and, HIF-PH3, HIF-prolyl hydroxylase 3, HPH-1, Hydroxylates HIF-1 alpha at 'Pro-564', Hypoxia-inducible factor prolyl hydroxylase 3, May play a role in cell growth regulation in muscle cells and in apoptosis in neuronal tissue, Nucleus, Prolyl hydroxylase domain-containing protein 3, Promotes cell death through a caspase-dependent mechanism, Widely expressed at low levels, [Catalytic Activity] An HIF alpha chain L-proline + 2-oxoglutarate+ O(2) = An HIF alpha chain trans-4-hydroxy-L-proline + succinate + CO(2), [Subcellular Location] Cytoplasm, and HIF-2 alpha, aortic endothelial cells and coronary artery smooth muscle) and placenta, targets HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitination complex, under normoxic conditions, )Catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins, PHD3 (Egl nine homolog 3 |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
EGLN3, Factor responsive smooth muscle protein, H Prolyl Hydroxylase 3, HP4H3, HPH3, P4H3, Prolyl Hydroxylase Domain Containing Protein 3, SM20, elegans 3, EGL9 homolog of C |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
PHD3 |
| Short name: |
PHD3 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
PHD3 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
14661 |
| Gene: |
EGLN3 |
More about : EGLN3 |
| Long gene name: |
egl-9 family hypoxia inducible factor 3 |
| Synonyms gene name: |
egl nine homolog 3 (C, elegans) |
| Synonyms: |
PHD3 HIFPH3 |
| Synonyms name: |
HIF prolyl hydroxylase 3 |
| Locus: |
14q13, 1 |
| Discovery year: |
2001-08-21 |
| GenBank acession: |
AJ310545 |
| Entrez gene record: |
112399 |
| Havana BLAST/BLAT: |
OTTHUMG00000029498 |