| Long name: |
Integrin beta 3 Primary Polyclonal Antibody |
| Also known as: |
Integrin beta 3 PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
Integrin beta 3 |
| Specificity: |
This is a highly specific antibody against Integrin beta 3 |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
27-77/788 |
| Subcellular location: |
Extracellular |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Integrin beta 3 |
| Gene ID number: |
3690 |
| Swiss Prot: |
P05106 |
| Tested Applications: |
ELISA, IF(ICC), IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
ELISA(1:500-1000), IF(ICC)(1:50-200), IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Fibrinogen binding enhances SELP expression in activated platelets (By similarity), Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen, In case of HIV-1 infection, Integrin alpha-IIb/beta-3 is a receptor for fibronectin, Integrin alpha-IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain, Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands, This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface, fibrinogen, fibronectin, laminin, matrix metalloproteinase-2, osteomodulin, osteopontin, plasminogen, prothrombin, prothrombin, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions, thrombospondin, thrombospondin and vitronectin, vitronectin and von Willebrand factor, Integrin alpha-V/beta-3 is a receptor for cytotactin |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
BDPLT16, BDPLT2, CD61, GP3A, GPIIIa, ITGB3, Integrin beta-3, Platelet membrane glycoprotein IIIa, GT |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
Integrin beta 3 |
| Short name: |
Integrin beta 3 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
Integrin b 3 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
6157 |
| Gene: |
ITGB3BP |
More about : ITGB3BP |
| Long gene name: |
integrin subunit beta 3 binding protein |
| Synonyms gene name: |
integrin beta 3 binding protein (beta3-endonexin) |
| Synonyms: |
NRIF3 HSU37139 TAP20 CENPR |
| Synonyms name: |
centromere protein R beta3-endonexin |
| Locus: |
1p31, 3 |
| Discovery year: |
2000-05-08 |
| GenBank acession: |
U37139 |
| Entrez gene record: |
23421 |
| Pubmed identfication: |
7593198 10490654 |
| RefSeq identity: |
NM_014288 |
| Havana BLAST/BLAT: |
OTTHUMG00000013364 |