| Long name: |
FITC Conjugated, CXCR3 Polyclonal Antibody |
| Category: |
Conjugated Primary Antibodies |
| Conjugation: |
Anti-FITC Antibody |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
CXCR3 |
| Specificity: |
This antibody is specific for isoform 2: CXCR3B, This is a highly specific antibody against CXCR3 |
| Modification: |
Unmodified |
| Modification site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen_range: |
5-50/415 |
| Subcellular location: |
Extracellular |
| Source: |
KLH conjugated synthetic peptide derived from human CXCR3 isoform 2 |
| Gene ID number: |
2833 |
| Swiss Prot: |
P49682 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Human |
| Crossreactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Antigen background: |
Binds to CCL21, CXCL10 and CXCL11 and mediates the proliferation, CXCL10 and CXCL11 on the proliferation, Does not promote cell chemotaxis respons, Interaction with CXCL4 or CXCL10 leads to activation of the p38MAPK pathway and contributes to inhibition of angiogenesis, Isoform 2: Receptor for the C-X-C chemokine CXCL4 and also mediates the inhibitory activities of CXCL9, Isoform 3: Mediates the activity of CXCL11, Overexpression in renal cancer cells down-regulates expression of the anti-apoptotic protein HMOX1 and promotes apoptosis, Probably promotes cell chemotaxis response, survival and angiogenic activity of human mesangial cells (HMC) through a heterotrimeric G-protein signaling pathway (PubMed:12782716), survival and angiogenic activity of human microvascular endothelial cells (HMVEC) through a cAMP-mediated signaling pathway (PubMed:12782716), Isoform 1: Receptor for the C-X-C chemokine CXCL9 |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA |
| Excitation Emission: |
494nm/518nm |
| Synonyms: |
CKR-L2 CMKAR3 IP10-R MigR CD183 |
| Properties: |
Bioss Primary Conjugated Antibodies FITC is highly sensitive to pH extremes, FITC has a green emission that's usually collected at 530 nanometers, FITC has a high quantum yield (efficiency of energy transfer from absorption to emission fluorescence) and approximately half of the absorbed photons are emitted as fluorescent light, For fluorescent microscopy applications, This Bioss Primary Conjugated Antibodies Fluorescein isothiocyanate (FITC) antibody is currently after some BD antibodies the most commonly used fluorescent dye for FACS, When excited at 488 nanometers, its photo bleaching effects are not observed due to a very brief interaction at the laser intercept, the 1 FITC is seldom used as it photo bleaches rather quickly though in flow cytometry applications, the FL1 detector of a FACSCalibur or FACScan, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
CXCR3 Conjugated |
| Short name: |
FITC Conjugated, CXCR3 Antibody |
| Technique: |
Fluorescein, antibodies against human proteins, antibodies for, antibody Conjugates, Antibody |
| Label: |
FITC |
| Alternative name: |
fluorecein coupled, chemokine (C-X-C motif) receptor 3 (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
C-X-C chemokine binding, CD182 and CD183 and CKR-L2 and CMKAR3 and GPR9 and IP10-R and Mig-R and MigR, CXCR3 and IDBG-635748 and ENSBTAG00000014798 and 497018, CXCR3 and IDBG-76333 and ENSG00000186810 and 2833, Cell surfaces, Cxcr3 and IDBG-164788 and ENSMUSG00000050232 and 12766, this GO :0001525 and angiogenesis and biological process this GO :0001937 and negative regulation of endothelial cell proliferation and biological process this GO :0002685 and regulation of leukocyte migration and biological process this GO :0004872 and receptor activity and molecular function this GO :0004930 and G-protein coupled receptor activity and molecular function this GO :0004950 and chemokine receptor activity and molecular function this GO :0005737 and cytoplasm and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0005887 and integral component of plasma membrane and cellular component this GO :0006915 and apoptotic process and biological process this GO :0006928 and cellular component movement and biological process this GO :0006935 and chemotaxis and biological process this GO :0006954 and inflammatory response and biological process this GO :0007155 and cell adhesion and biological process this GO :0007166 and cell surface receptor signaling pathway and biological process this GO :0007186 and G-protein coupled receptor signaling pathway and biological process this GO :0007204 and positive regulation of cytosolic calcium ion concentration and biological process this GO :0008284 and positive regulation of cell proliferation and biological process this GO :0009897 and external side of plasma membrane and cellular component this GO :0009986 and cell surface and cellular component this GO :0010818 and T cell chemotaxis and biological process this GO :0016021 and integral component of membrane and cellular component this GO :0016494 and C-X-C chemokine receptor activity and molecular function this GO :0016525 and negative regulation of angiogenesis and biological process this GO :0019722 and calcium-mediated signaling and biological process this GO :0019956 and chemokine binding and molecular function this GO :0019958 and C-X-C chemokine binding and molecular function this GO :0030816 and positive regulation of cAMP metabolic process and biological process this GO :0043950 and positive regulation of cAMP-mediated signaling and biological process this GO :0045087 and innate immune response and biological process this GO :0045766 and positive regulation of angiogenesis and biological process this GO :0045944 and positive regulation of transcription from RNA polymerase II promoter and biological process this GO :0050921 and positive regulation of chemotaxis and biological process this GO :0051281 and positive regulation of release of sequestered calcium ion into cytosol and biological process this GO :0071954 and chemokine (C-C motif) ligand 11 production and biological process this GO :1900118 and negative regulation of execution phase of apoptosis and biological process this GO :1900119 and positive regulation of execution phase of apoptosis and biological process, this GO :0004872 : receptor activity, this GO :0004872 : receptor activity and also this GO :0004930 : G-protein coupled receptor activity and also this GO :0004950 : chemokine receptor activity and also this GO :0016494 : C-X-C chemokine receptor activity and also this GO :0019956 : chemokine binding and also this GO :0019958 : C-X-C chemokine binding, this GO :0004930 : G-protein coupled receptor activity, this GO :0004950 : chemokine receptor activity, this GO :0016494 : C-X-C chemokine receptor activity, this GO :0019956 : chemokine binding, this GO :0019958 : C-X-C chemokine binding, chemokine (C-X-C motif) receptor 3 |
| Identity: |
4540 |
| Gene: |
CXCR3 |
More about : CXCR3 |
| Long gene name: |
C-X-C motif chemokine receptor 3 |
| Synonyms gene: |
GPR9 |
| Synonyms gene name: |
G protein-coupled receptor 9 chemokine (C-X-C motif) receptor 3 |
| Locus: |
Xq13, 1 |
| Discovery year: |
1994-11-01 |
| GenBank acession: |
U32674 |
| Entrez gene record: |
2833 |
| Pubmed identfication: |
8666380 9064356 |
| Classification: |
CD molecules C-X-C motif chemokine receptors |
| Havana BLAST/BLAT: |
OTTHUMG00000033326 |