| Long name: |
Biotin Conjugated, Trk B Polyclonal Antibody |
| Category: |
Conjugated Primary Antibodies |
| Conjugation: |
Biotinylated |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
TrkB |
| Specificity: |
This is a highly specific antibody against TrkB |
| Modification: |
Unmodified |
| Modification site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen_range: |
30-80/822 |
| Subcellular location: |
Extracellular |
| Source: |
KLH conjugated synthetic peptide derived from human Trk B |
| Gene ID number: |
4915 |
| Swiss Prot: |
Q16620 |
| Tested applications: |
IHC-P, WB |
| Recommended dilutions: |
IHC-P(1:100-500), WB(1:100-1000) |
| Crossreactivity: |
Mouse, Rat, Human |
| Crossreactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Antigen background: |
Alternatively can also bind NTF3/neurotrophin-3 which is less efficient in activating the receptor but regulates neuron survival through NTRK2, FRS2, FRS2, Hence, May also play a role in neutrophin-dependent calcium signaling in glial cells and mediate communication between neurons and glia, PLCG1 also leads to NF-Kappa-B activation and the transcription of genes involved in cell survival, Receptor for BDNF/brain-derived neurotrophic factor and NTF4/neurotrophin-4, Recruits, SH2B1, SH2B1, SH2B2 activates the GRB2-Ras-MAPK cascade that regulates for instance neuronal differentiation including neurite outgrowth, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades, Thereby, Through PLCG1 and the downstream protein kinase C-regulated pathways controls synaptic plasticity, Through SHC1, Through the same effectors controls the Ras-PI3 kinase-AKT1 signaling cascade that mainly regulates growth and survival, Upon ligand-binding, and synapse formation and plasticity, autophosphorylation and activation, differentiation, it is able to suppress anoikis, migration, phosphorylates and/or activates several downstream effectors including SHC1, plays a role in learning and memory by regulating both short term synaptic function and long-term potentiation, proliferation, the apoptosis resulting from loss of cell-matrix interactions, undergoes homodimerization, Receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA |
| Synonyms: |
BDNF/NT-3 growth factors receptor, GP145-TrkB, NTRK2, Neurotrophic tyrosine kinase receptor type 2, TrkB tyrosine kinase, Tropomyosin-related kinase B, trk-B, TRKB |
| Properties: |
Avidin and Streptavidin bind to the small biotin and are couple to HRP or AP for ELISA, Biotin conjugates can be detected by horseradish peroxidase, To break the streptavidin Biotin bond we suggest to use a 6 molar guanidine HCl solution with acidity of pH 1, alkaline phosphatase substrates or anti biotin conjugated antibodies, 6, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
Trk B Conjugated |
| Short name: |
Conjugated, Trk B Antibody |
| Technique: |
antibodies against human proteins, antibodies for, antibody Conjugates, Antibody |
| Label: |
Biotin |
| Alternative name: |
biotinilated coupled, Trk B (Antibody to) |
| Alternative technique: |
antibodies |