| Long name: |
ALEXA FLUOR 647 Conjugated, Protein kinase C beta IsoformII Antibody |
| Also known as: |
Anti-PKC beta PAb ALEXA FLUOR 647 |
| Category: |
Conjugated Primary Antibodies |
| Conjugated with: |
647, ALEXA FLUOR® |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
PKC beta |
| Specificity: |
This is a highly specific antibody against PKC beta |
| Modification: |
Unmodified |
| Modification Site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
620-673/673 |
| Subcellular location: |
Cell membrane, Nucleus, Cytoplasm |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human PKC beta 2 |
| Gene ID Number: |
5579 |
| Swiss Prot: |
P05771 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Cross-reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the antigen: |
'Ser-644' and 'Ser-652', Acts as a coactivator of androgen receptor (ANDR)-dependent transcription, In insulin signaling, Involved in apoptosis following oxidative damage: in case of oxidative conditions, May participate in the regulation of glucose transport in adipocytes by negatively modulating the insulin-stimulated translocation of the glucose transporter SLC2A4/GLUT4, Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11/CARMA1 at 'Ser-559', Phosphorylation induces CARD11/CARMA1 association with lipid rafts and recruitment of the BCL10-MALT1 complex as well as MAP3K7/TAK1, Plays a direct role in the negative feedback regulation of the BCR signaling, Plays a key role in B-cell activation by regulating BCR-induced NF-kappa-B activation, a specific tag for epigenetic transcriptional activation that prevents demethylation of histone H3 'Lys-4' (H3K4me) by LSD1/KDM1A, androgen receptor-dependent transcription regulation, by being recruited to ANDR target genes and specifically mediating phosphorylation of 'Thr-6' of histone H3 (H3T6ph), by down-modulating BTK function via direct phosphorylation of BTK at 'Ser-180', insulin signaling and endothelial cells proliferation, leading to mitochondrial accumulation of p66Shc, may function downstream of IRS1 in muscle cells and mediate insulin-dependent DNA synthesis through the RAF1-MAPK/ERK signaling cascade, oxidative stress-induced apoptosis, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase involved in various cellular processes such as regulation of the B-cell receptor (BCR) signalosome, resulting in nuclear translocation and activation of NFKB1, specifically phosphorylates 'Ser-36' of isoform p66Shc of SHC1, where p66Shc acts as a reactive oxygen species producer, which results in the alteration of BTK plasma membrane localization and in turn inhibition of BTK activity, which then activates IKK complex, Calcium-activated |
| Purification: |
Purified by Protein A |
| Storage conditions: |
50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA |
| Excitation emission: |
650nm/665nm |
| Synonyms: |
PKC-B, PKC-beta, PRKCB, PRKCB1, PRKCB2, Protein kinase C beta type, PKCB |
| Properties: |
ALEXA FLUOR made this Alexa Fluor 633 conjugate that can be used in multi-color flow cytometry with instruments equipped with a second red laser or red diode, ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 633 is a practical alternative to APC as well as Cy5, Bioss Primary Conjugated Antibodies, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, It is detected in the FL4 detector of the core's upgraded 2-laser FACScans, Like other Alexa Fluor dyes, exhibits uncommon photo stability, making it an ideal choice for fluorescent microscopy, the Protein kinase C beta IsoformII Antibody, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
ALEXA FLUOR 647, Alexa Fluor |
| Gene target: |
Protein kinase C beta IsoformII |
| Short name: |
Protein kinase C beta IsoformII Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Label: |
ALEXA FLUOR 647 |
| Alternative name: |
ALEXA FLUOR 647, Protein phosphorylation catalyst C b IsoformII (Antibody to) |
| Alternative technique: |
antibodies |