| Reacts with: |
Mouse |
| Source: |
proteins, Recombinants or rec |
| Description: |
Recombinant Mouse alpha-Synuclein is produced by our E, coli expression system and the target gene encoding Met1-Ala140 is expressed with a 6His tag at the N-terminus |
| Molecular Weight: |
15, 9 kD |
| UniProt number: |
O55042 |
| State of the product: |
Freeze-dried |
| Shipping conditions: |
Ambient temperature |
| Formulation: |
150 mM sodium chloride, pH 7, 2 um filtered solution of 20 mM PB, 4, Lyophilized from a 0 |
| Storage recommendations: |
-20°, Aliquots of reconstituted samples are stable at less -20°, If kept at at room temperature, If kept at at room temperature, Reconstituted protein solution should be stored at 4-7°, it is stable for 3 weeks, it is stable for 3 weeks, C, C for 2-7 days, C for 3 months, Freeze-dried proteins should be stored frozen at < |
| Reconstitution: |
Dissolve the lyophilized protein in ddH2O, Do not mix by vortex or pipetting, It is not recommended to reconstitute to a concentration less than 100 &mu, Please aliquot the reconstituted solution to minimize freeze-thaw cycles, Always centrifuge tubes before opening, g/ml |
| Purity: |
and determined by Polyacrylamide gel electrophoresis, Greater than 95% |
| Sequence of the amino acid: |
MNHKVHHHHHHMDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVTTVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGNIAAATGFVKKDQMGKGEEGYPQEGILEDMPVDPGSEAYEMPSEEGYQDYEPEA |
| Levels of endotoxin: |
11 IEU/ug, LAL test shows less than than 0 |
| Test: |
A/J, BALB/c, Mouse are mature after 40 days for females and 55 days for males, SCID while the CD-1 is outbred as strain, The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year, Transgenic, congenic and inbread strains are known for C57BL/6, knock-out, Mouse , mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab, or |
| Latin name: |
Mus musculus |
| Group: |
recombinants |
| Gene target: |
SNCA (N-6His), &alpha, -Synuclein |
| Short name: |
SNCA (N-6His), -Synuclein, Recombinant Mouse &alpha |
| Technique: |
E, coli recombinant proteins are , mouses, novo advises they will be reconstituted in a buffer soluion or culture medium for cell culture, supplied as white sterile powder lyopillized, Recombinant, genetic recombinations , in Escherichia coli |
| Species: |
Mouses |
| Alternative name: |
alpha (non A4 component on amyloid precursor) (N-6His), synuclein, -Synuclein, recombinant Mouse &alpha |
| Alternative technique: |
rec |
| Alternative to gene target: |
NACP and PARK1 and PARK4 and PD1, SNCA and IDBG-30077 and ENSG00000145335 and 6622, SNCA and IDBG-641103 and ENSBTAG00000024957 and 282857, Snca and IDBG-152558 and ENSMUSG00000025889 and 20617, alpha (non A4 component of amyloid precursor), dopaminergic and biological process this GO :0005507 and copper ion binding and molecular function this GO :0005509 and calcium ion binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005543 and phospholipid binding and molecular function this GO :0005576 and extracellular region and cellular component this GO :0005634 and nucleus and cellular component this GO :0005640 and nuclear outer membrane and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005739 and mitochondrion and cellular component this GO :0005764 and lysosome and cellular component this GO :0005791 and rough endoplasmic reticulum and cellular component this GO :0005794 and this GO lgi apparatus and cellular component this GO :0005829 and cytosol and cellular component this GO :0005840 and ribosome and cellular component this GO :0005856 and cytoskeleton and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0005938 and cell cortex and cellular component this GO :0006631 and fatty acid metabolic process and biological process this GO :0006638 and neutral lipid metabolic process and biological process this GO :0006644 and phospholipid metabolic process and biological process this GO :0006919 and activation of cysteine-type endopeptidase activity involved in apoptotic process and biological process this GO :0007006 and mitochondrial membrane organization and biological process this GO :0007268 and synaptic transmission and biological process this GO :0007568 and aging and biological process this GO :0008017 and microtubule binding and molecular function this GO :0008021 and synaptic vesicle and cellular component this GO :0008198 and ferrous iron binding and molecular function this GO :0008270 and zinc ion binding and molecular function this GO :0008344 and adult locomotory behavior and biological process this GO :0010040 and response to iron(II) ion and biological process this GO :0010517 and regulation of phospholipase activity and biological process this GO :0010642 and negative regulation of platelet-derived growth factor receptor signaling pathway and biological process this GO :0014048 and regulation of glutamate secretion and biological process this GO :0014059 and regulation of dopamine secretion and biological process this GO :0015629 and actin cytoskeleton and cellular component this GO :0016234 and inclusion body and cellular component this GO :0016491 and oxidoreductase activity and molecular function this GO :0019894 and kinesin binding and molecular function this GO :0019899 and enzyme binding and molecular function this GO :0019904 and protein domain specific binding and molecular function this GO :0030054 and cell junction and cellular component this GO :0030424 and axon and cellular component this GO :0030426 and growth cone and cellular component this GO :0030544 and Hsp70 protein binding and molecular function this GO :0030659 and cytoplasmic vesicle membrane and cellular component this GO :0031092 and platelet alpha granule membrane and cellular component this GO :0031115 and negative regulation of microtubule polymerization and biological process this GO :0031623 and receptor internalization and biological process this GO :0031648 and protein destabilization and biological process this GO :0032026 and response to magnesium ion and biological process this GO :0032410 and negative regulation of transporter activity and biological process this GO :0032496 and response to lipopolysaccharide and biological process this GO :0032769 and negative regulation of monooxygenase activity and biological process this GO :0033138 and positive regulation of peptidyl-serine phosphorylation and biological process this GO :0034341 and response to interferon-gamma and biological process this GO :0034599 and cellular response to oxidative stress and biological process this GO :0035067 and negative regulation of histone acetylation and biological process this GO :0040012 and regulation of locomotion and biological process this GO :0042220 and response to cocaine and biological process this GO :0042393 and histone binding and molecular function this GO :0042416 and dopamine biosynthetic process and biological process this GO :0042417 and dopamine metabolic process and biological process this GO :0042493 and response to drug and biological process this GO :0042775 and mitochondrial ATP synthesis coupled electron transport and biological process this GO :0042802 and identical protein binding and molecular function this GO :0043014 and alpha-tubulin binding and molecular function this GO :0043027 and cysteine-type endopeptidase inhibitor activity involved in apoptotic process and molecular function this GO :0043030 and regulation of macrophage activation and biological process this GO :0043066 and negative regulation of apoptotic process and biological process this GO :0043154 and negative regulation of cysteine-type endopeptidase activity involved in apoptotic process and biological process this GO :0043195 and terminal bouton and cellular component this GO :0043205 and fibril and cellular component this GO :0043206 and extracellular fibril organization and biological process this GO :0043231 and intracellular membrane-bounded organelle and cellular component this GO :0043274 and phospholipase binding and molecular function this GO :0043524 and negative regulation of neuron apoptotic process and biological process this GO :0043679 and axon terminus and cellular component this GO :0044344 and cellular response to fibroblast growth factor stimulus and biological process this GO :0045087 and innate immune response and biological process this GO :0045202 and synapse and cellular component this GO :0045502 and dynein binding and molecular function this GO :0045807 and positive regulation of endocytosis and biological process this GO :0045920 and negative regulation of exocytosis and biological process this GO :0045963 and negative regulation of dopamine metabolic process and biological process this GO :0046928 and regulation of neurotransmitter secretion and biological process this GO :0047485 and protein N-terminus binding and molecular function this GO :0048148 and behavioral response to cocaine and biological process this GO :0048156 and tau protein binding and molecular function this GO :0048168 and regulation of neuronal synaptic plasticity and biological process this GO :0048169 and regulation of long-term neuronal synaptic plasticity and biological process this GO :0048471 and perinuclear region of cytoplasm and cellular component this GO :0048487 and beta-tubulin binding and molecular function this GO :0048488 and synaptic vesicle endocytosis and biological process this GO :0048489 and synaptic vesicle transport and biological process this GO :0050544 and arachidonic acid binding and molecular function this GO :0050806 and positive regulation of synaptic transmission and biological process this GO :0050808 and synapse organization and biological process this GO :0050812 and regulation of acyl-CoA biosynthetic process and biological process this GO :0051219 and phosphoprotein binding and molecular function this GO :0051281 and positive regulation of release of sequestered calcium ion into cytosol and biological process this GO :0051583 and dopamine uptake involved in synaptic transmission and biological process this GO :0051585 and negative regulation of dopamine uptake involved in synaptic transmission and biological process this GO :0051612 and negative regulation of serotonin uptake and biological process this GO :0051622 and negative regulation of norepinephrine uptake and biological process this GO :0055114 and oxidation-reduction process and biological process this GO :0060079 and regulation of excitatory postsynaptic membrane potential and biological process this GO :0060291 and long-term synaptic potentiation and biological process this GO :0060732 and positive regulation of inositol phosphate biosynthetic process and biological process this GO :0061024 and membrane organization and biological process this GO :0070495 and negative regulation of thrombin receptor signaling pathway and biological process this GO :0070555 and response to interleukin-1 and biological process this GO :0071280 and cellular response to copper ion and biological process this GO :0071872 and cellular response to epinephrine stimulus and biological process this GO :0071902 and positive regulation of protein serine/threonine kinase activity and biological process this GO :1901214 and regulation of neuron death and biological process, nuclei, phosphoprotein binding, this GO :0000287 and magnesium ion binding and molecular function this GO :0001774 and microglial cell activation and biological process this GO :0001921 and positive regulation of receptor recycling and biological process this GO :0001933 and negative regulation of protein phosphorylation and biological process this GO :0001956 and positive regulation of neurotransmitter secretion and biological process this GO :0001963 and synaptic transmission, this GO :0000287 : magnesium ion binding, this GO :0000287 : magnesium ion binding and also this GO :0005507 : copper ion binding and also this GO :0005509 : calcium ion binding and also this GO :0005515 : protein binding and also this GO :0005543 : phospholipid binding and also this GO :0008017 : microtubule binding and also this GO :0008198 : ferrous iron binding and also this GO :0008270 : zinc ion binding and also this GO :0016491 : oxidoreductase activity and also this GO :0019894 : kinesin binding and also this GO :0019899 : enzyme binding and also this GO :0019904 : protein domain specific binding and also this GO :0030544 : Hsp70 protein binding and also this GO :0042393 : histone binding and also this GO :0042802 : identical protein binding and also this GO :0043014 : alpha-tubulin binding and also this GO :0043027 : cysteine-type endopeptidase inhibitor activity involved in apoptotic process and also this GO :0043274 : phospholipase binding and also this GO :0045502 : dynein binding and also this GO :0047485 : protein N-terminus binding and also this GO :0048156 : tau protein binding and also this GO :0048487 : beta-tubulin binding and also this GO :0050544 : arachidonic acid binding and also this GO :0051219 : phosphoprotein binding, this GO :0005507 : copper ion binding, this GO :0005509 : calcium ion binding, this GO :0005515 : protein binding, this GO :0005543 : phospholipid binding, this GO :0008017 : microtubule binding, this GO :0008198 : ferrous iron binding, this GO :0008270 : zinc ion binding, this GO :0016491 : oxidoreductase activity, this GO :0019894 : kinesin binding, this GO :0019899 : enzyme binding, this GO :0019904 : protein domain specific binding, this GO :0030544 : Hsp70 protein binding, this GO :0042393 : histone binding, this GO :0042802 : identical protein binding, this GO :0043014 : alpha-tubulin binding, this GO :0043027 : cysteine-type endopeptidase inhibitor activity involved in apoptotic process, this GO :0043274 : phospholipase binding, this GO :0045502 : dynein binding, this GO :0047485 : protein N-terminus binding, this GO :0048156 : tau protein binding, this GO :0048487 : beta-tubulin binding, this GO :0050544 : arachidonic acid binding, this GO :0051219 : phosphoprotein binding, synuclein |
| Identity: |
11138 |
| Gene: |
SNCA |
More about : SNCA |
| Long gene name: |
synuclein alpha |
| Synonyms gene: |
PARK1 PARK4 |
| Synonyms gene name: |
Lewy body) 4 synuclein, Parkinson disease (autosomal dominant, alpha (non A4 component of amyloid precursor) |
| Synonyms: |
NACP PD1 alpha-synuclein |
| Synonyms name: |
non A4 component of amyloid precursor |
| Locus: |
4q22, 1 |
| Discovery year: |
1995-01-24 |
| GenBank acession: |
L08850 |
| Entrez gene record: |
6622 |
| Pubmed identfication: |
8248242 14593171 |
| Classification: |
Parkinson disease associated genes |
| Havana BLAST/BLAT: |
OTTHUMG00000130948 |
| Locus Specific Databases: |
Parkinson', s disease Mutation Database |