| Reacts with: |
Human |
| Source: |
proteins, Recombinants or rec |
| Description: |
Recombinant Human Proprotein Convertase 9 is produced by our Mammalian expression system and the target gene encoding Gln31-Gln692 is expressed with a AVI tag at the C-terminus |
| Molecular Weight: |
05 kD, 71 |
| UniProt number: |
Q8NBP7 |
| State of the product: |
Liquid |
| Shipping conditions: |
Dry Ice/ice packs |
| Formulation: |
150 mM sodium chloride, pH 7, 2 um filtered solution of 50 mM HEPES, 4, Supplied as a 0 |
| Storage recommendations: |
-20°, Please minimize freeze-thaw cycles, stable for 6 months after receipt, C, Store at < |
| Reconstitution: |
Dissolve the lyophilized protein in ddH2O, Do not mix by vortex or pipetting, It is not recommended to reconstitute to a concentration less than 100 &mu, Please aliquot the reconstituted solution to minimize freeze-thaw cycles, Always centrifuge tubes before opening, g/ml |
| Purity: |
and determined by Polyacrylamide gel electrophoresis, Greater than 95% |
| Sequence of the amino acid: |
QEDEDGDYEELVLALRSEEDGLAEAPEHGTTATFHRCAKDPWRLPGTYVVVLKEETHLSQSERTARRLQAQAARRGYLTKILHVFHGLLPGFLVKMSGDLLELALKLPHVDYIEEDSSVFAQSIPWNLERITPPRYRADEYQPPDGGSLVEVYLLDTSIQSDHREIEGRVMVTDFENVPEEDGTRFHRQASKCDSHGTHLAGVVSGRDAGVAKGASMRSLRVLNCQGKGTVSGTLIGLEFIRKSQLVQPVGPLVVLLPLAGGYSRVLNAACQRLARAGVVLVTAAGNFRDDACLYSPASAPEVITVGATNAQDQPVTLGTLGTNFGRCVDLFAPGEDIIGASSDCSTCFVSQSGTSQAAAHVAGIAAMMLSAEPELTLAELRQRLIHFSAKDVINEAWFPEDQRVLTPNLVAALPPSTHGAGWQLFCRTVWSAHSGPTRMATAIARCAPDEELLSCSSFSRSGKRRGERMEAQGGKLVCRAHNAFGGEGVYAIARCCLLPQANCSVHTAPPAEASMGTRVHCHQQGHVLTGCSSHWEVEDLGTHKPPVLRPRGQPNQCVGHREASIHASCCHAPGLECKVKEHGIPAPQEQVTVACEEGWTLTGCSALPGTSHVLGAYAVDNTCVVRSRDVSTTGSTSEEAVTAVAICCRSRHLAQASQELQEFGGGLNDIFEAQKIEWHE |
| Levels of endotoxin: |
11 IEU/ug, LAL test shows less than than 0 |
| Properties: |
Depending on the epitopes used human ELISA kits can be cross reactive to many other species, Mainly analyzed are human serum, Modern , cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies, human cell culture supernatants and biological samples, plasma, primarily , saliva, urine, , (Homo sapiens, Homo sapiens sapiens), Human proteins, humans , ssp |
| Group: |
recombinants |
| Gene target: |
Kexin 9, PCSK9 (C-AVI), Proprotein Convertase Subtilisin |
| Short name: |
Kexin 9, PCSK9 (C-AVI), Recombinant Proprotein Convertase Subtilisin |
| Technique: |
E, coli recombinant proteins are , novo advises they will be reconstituted in a buffer soluion or culture medium for cell culture, supplied as white sterile powder lyopillized, Recombinant, genetic recombinations , in Escherichia coli |
| Species: |
Humans, Human |
| Alternative name: |
Kexin classification 9, proprotein convertase subtilisin/kexin classification 9 (C-AVI), sapiens Proprotein Convertase Subtilisin, recombinant H |
| Alternative technique: |
rec |
| Alternative to gene target: |
Extracellular, PCSK9 and IDBG-99082 and ENSG00000169174 and 255738, Pcsk9 and IDBG-170186 and ENSMUSG00000044254 and 100102, this GO :0001822 and kidney development and biological process this GO :0001889 and liver development and biological process this GO :0001920 and negative regulation of receptor recycling and biological process this GO :0002092 and positive regulation of receptor internalization and biological process this GO :0004252 and serine-type endopeptidase activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005576 and extracellular region and cellular component this GO :0005615 and extracellular space and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005764 and lysosome and cellular component this GO :0005769 and early endosome and cellular component this GO :0005770 and late endosome and cellular component this GO :0005783 and endoplasmic reticulum and cellular component this GO :0005791 and rough endoplasmic reticulum and cellular component this GO :0005794 and this GO lgi apparatus and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0006508 and proteolysis and biological process this GO :0006641 and triglyceride metabolic process and biological process this GO :0006644 and phospholipid metabolic process and biological process this GO :0006915 and apoptotic process and biological process this GO :0007041 and lysosomal transport and biological process this GO :0008203 and cholesterol metabolic process and biological process this GO :0009267 and cellular response to starvation and biological process this GO :0009986 and cell surface and cellular component this GO :0010469 and regulation of receptor activity and biological process this GO :0010989 and negative regulation of low-density lipoprotein particle clearance and biological process this GO :0016485 and protein processing and biological process this GO :0016540 and protein autoprocessing and biological process this GO :0019871 and sodium channel inhibitor activity and molecular function this GO :0022008 and neurogenesis and biological process this GO :0030134 and ER to this GO lgi transport vesicle and cellular component this GO :0030169 and low-density lipoprotein particle binding and molecular function this GO :0030182 and neuron differentiation and biological process this GO :0031232 and extrinsic component of external side of plasma membrane and cellular component this GO :0032799 and low-density lipoprotein receptor particle metabolic process and biological process this GO :0032802 and low-density lipoprotein particle receptor catabolic process and biological process this GO :0032803 and regulation of low-density lipoprotein particle receptor catabolic process and biological process this GO :0032869 and cellular response to insulin stimulus and biological process this GO :0034185 and apolipoprotein binding and molecular function this GO :0034189 and very-low-density lipoprotein particle binding and molecular function this GO :0034190 and apolipoprotein receptor binding and molecular function this GO :0042157 and lipoprotein metabolic process and biological process this GO :0042632 and cholesterol homeostasis and biological process this GO :0043523 and regulation of neuron apoptotic process and biological process this GO :0043525 and positive regulation of neuron apoptotic process and biological process this GO :0043621 and protein self-association and molecular function this GO :0044822 and poly(A) RNA binding and molecular function this GO :0048471 and perinuclear region of cytoplasm and cellular component this GO :0050750 and low-density lipoprotein particle receptor binding and molecular function this GO :0070326 and very-low-density lipoprotein particle receptor binding and molecular function, this GO :0004252 : serine-type endopeptidase activity, this GO :0004252 : serine-type endopeptidase activity and also this GO :0005515 : protein binding and also this GO :0019871 : sodium channel inhibitor activity and also this GO :0030169 : low-density lipoprotein particle binding and also this GO :0034185 : apolipoprotein binding and also this GO :0034189 : very-low-density lipoprotein particle binding and also this GO :0034190 : apolipoprotein receptor binding and also this GO :0043621 : protein self-association and also this GO :0044822 : poly(A) RNA binding and also this GO :0050750 : low-density lipoprotein particle receptor binding and also this GO :0070326 : very-low-density lipoprotein particle receptor binding, this GO :0005515 : protein binding, this GO :0019871 : sodium channel inhibitor activity, this GO :0030169 : low-density lipoprotein particle binding, this GO :0034185 : apolipoprotein binding, this GO :0034189 : very-low-density lipoprotein particle binding, this GO :0034190 : apolipoprotein receptor binding, this GO :0043621 : protein self-association, this GO :0044822 : poly(A) RNA binding, this GO :0050750 : low-density lipoprotein particle receptor binding, this GO :0070326 : very-low-density lipoprotein particle receptor binding, very-low-density lipoprotein particle receptor binding, proprotein convertase subtilisin/kexin type 9 |
| Identity: |
20001 |
| Gene: |
PCSK9 |
More about : PCSK9 |
| Long gene name: |
proprotein convertase subtilisin/kexin type 9 |
| Synonyms gene: |
HCHOLA3 |
| Synonyms gene name: |
autosomal dominant 3 , hypercholesterolemia |
| Synonyms: |
NARC-1 FH3 |
| Locus: |
1p32, 3 |
| Discovery year: |
2003-05-13 |
| GenBank acession: |
AX207686 |
| Entrez gene record: |
255738 |
| Pubmed identfication: |
12552133 12730697 |
| RefSeq identity: |
NM_174936 |
| Classification: |
Proprotein convertase subtilisin/kexin family |
| Havana BLAST/BLAT: |
OTTHUMG00000008136 |
| Locus Specific Databases: |
British Heart Foundation LRG_275 |