| Category: |
Antibody |
| Concentration: |
pH 7, with 0, 09% sodium azide, 4, In 1X PBS |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
CHD5 / Chromodomain-helicase-DNA-binding protein 5 |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
WB |
| Recommended dilutions: |
Western blot: 1:1000-2000 |
| Intented use: |
This CHD5 antibodyis to be used only for research purposes and not for diagnostics |
| Gene ID #: |
26038 |
| Uniprot #: |
Q8TDI0 |
| Purity: |
Antigen affinity |
| Description: |
Downstream activated genes may include CDKN2A that positively regulates the p53/TP53 pathway, In parallel, In spermatogenesis, May specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non- methylated 'Lys-4' of histone H3, Plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation, Tumor suppressor, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa, it may also positively regulate the trimethylation of histone H3 at 'Lys- 27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, it regulates the expression of genes involved in cell proliferation and differentiation, prevents cell proliferation, which in turn, Chromodomain-helicase-DNA-binding protein 5 is a chromatin-remodeling protein that binds DNA through histones and regulates gene transcription |
| Immunogen: |
A portion of amino acids 64-98 from the human protein was used as the immunogen for the CHD5 antibody |
| Storage: |
Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the CHD5 antibody and store frozen at -20 deg |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
CHD5 / Chromodomain-helicase-DNA-binding protein 5 |
| Short name: |
CHD5 Antibody / Chromodomain-helicase-DNA-binding protein 5 |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
CHD5 (Antibody to) / Chromodomain-helicase-Desoxyribonucleic acid-binding protein 5 |
| Alternative technique: |
antibodies |
| Identity: |
16816 |
| Gene: |
CHD5 |
More about : CHD5 |
| Long gene name: |
chromodomain helicase DNA binding protein 5 |
| Locus: |
1p36, 31 |
| Discovery year: |
2002-11-29 |
| GenBank acession: |
AF425231 |
| Entrez gene record: |
26038 |
| Pubmed identfication: |
11889561 12592387 |
| RefSeq identity: |
NM_015557 |
| Classification: |
NuRD complex PHD finger proteins |
| Havana BLAST/BLAT: |
OTTHUMG00000000952 |