| Category: |
Antibody |
| Concentration: |
pH 7, with 0, 09% sodium azide, 4, In 1X PBS |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
Protein Phosphatase 2A / PPP2R4 |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus) , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
WB |
| Recommended dilutions: |
Western blot: 1:1000-2000 |
| Intented use: |
This PPP2R4 antibodyis to be used only for research purposes and not for diagnostics |
| Gene ID #: |
5524 |
| Uniprot #: |
Q15257 |
| Purity: |
Antigen affinity |
| Description: |
Acts as a regulatory subunit for serine/threonine- protein phosphatase 2A (PP2A) modulating its activity or substrate specificity, Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2A(i)) in presence of ATP and Mg(2+) (By similarity), Is involved in apoptosis, It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides, Reversibly stimulates the variable phosphotyrosyl phosphatase activity of PP2A core heterodimer PP2A(D) in presence of ATP and Mg(2+) (in vitro), The phosphotyrosyl phosphatase activity is dependent of an ATPase activity of the PP2A(D):PPP2R4 complex, a proposed direct target of the PPIase, probably by inducing a conformational change in the catalytic subunit, the function appears to be independent from PP2A, PPIases accelerate the folding of proteins |
| Immunogen: |
A portion of amino acids 3-35 from the human protein was used as the immunogen for the PPP2R4 antibody |
| Storage: |
Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the PPP2R4 antibody and store frozen at -20 deg |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
Protein Phosphatase 2A / PPP2R4 |
| Short name: |
Protein Phosphatase 2A Antibody / PPP2R4 |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
regulatory subunit 4, Protein Phosphatase 2A (Antibody to) / protein phosphatase 2A activator |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
PP2A and PR53 and PTPA, PPP2R4 and IDBG-639691 and ENSBTAG00000001933 and 514460, PPP2R4 and IDBG-89032 and ENSG00000119383 and 5524, Ppp2r4 and IDBG-156714 and ENSMUSG00000039515 and 110854, nuclei, protein phosphatase 2A binding, regulatory subunit 4, this GO :0000159 and protein phosphatase type 2A complex and cellular component this GO :0000413 and protein peptidyl-prolyl isomerization and biological process this GO :0003755 and peptidyl-prolyl cis-trans isomerase activity and molecular function this GO :0005102 and receptor binding and molecular function this GO :0005524 and ATP binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0006200 and ATP catabolic process and biological process this GO :0006457 and protein folding and biological process this GO :0008160 and protein tyrosine phosphatase activator activity and molecular function this GO :0008601 and protein phosphatase type 2A regulator activity and molecular function this GO :0016887 and ATPase activity and molecular function this GO :0019211 and phosphatase activator activity and molecular function this GO :0030472 and mitotic spindle organization in nucleus and biological process this GO :0032515 and negative regulation of phosphoprotein phosphatase activity and biological process this GO :0032516 and positive regulation of phosphoprotein phosphatase activity and biological process this GO :0034704 and calcium channel complex and cellular component this GO :0035307 and positive regulation of protein dephosphorylation and biological process this GO :0035308 and negative regulation of protein dephosphorylation and biological process this GO :0042803 and protein homodimerization activity and molecular function this GO :0043065 and positive regulation of apoptotic process and biological process this GO :0043085 and positive regulation of catalytic activity and biological process this GO :0043666 and regulation of phosphoprotein phosphatase activity and biological process this GO :0046982 and protein heterodimerization activity and molecular function this GO :0051721 and protein phosphatase 2A binding and molecular function this GO :0070062 and extracellular vesicular exosome and cellular component, this GO :0003755 : peptidyl-prolyl cis-trans isomerase activity, this GO :0003755 : peptidyl-prolyl cis-trans isomerase activity and also this GO :0005102 : receptor binding and also this GO :0005524 : ATP binding and also this GO :0008160 : protein tyrosine phosphatase activator activity and also this GO :0008601 : protein phosphatase type 2A regulator activity and also this GO :0016887 : ATPase activity and also this GO :0019211 : phosphatase activator activity and also this GO :0042803 : protein homodimerization activity and also this GO :0046982 : protein heterodimerization activity and also this GO :0051721 : protein phosphatase 2A binding, this GO :0005102 : receptor binding, this GO :0005524 : ATP binding, this GO :0008160 : protein tyrosine phosphatase activator activity, this GO :0008601 : protein phosphatase type 2A regulator activity, this GO :0016887 : ATPase activity, this GO :0019211 : phosphatase activator activity, this GO :0042803 : protein homodimerization activity, this GO :0046982 : protein heterodimerization activity, this GO :0051721 : protein phosphatase 2A binding, protein phosphatase 2A activator |
| Identity: |
9308 |
| Gene: |
PTPA |
More about : PTPA |
| Long gene name: |
protein phosphatase 2 phosphatase activator |
| Synonyms gene: |
PPP2R4 |
| Synonyms gene name: |
(PR 53) protein phosphatase 2A activator, protein phosphatase 2A, regulatory subunit 4 protein phosphatase 2 regulatory subunit 4 , regulatory subunit B' |
| Synonyms: |
PR53 |
| Synonyms name: |
phosphotyrosyl phosphatase activator PP2A phosphatase activator |
| Locus: |
9q34, 11 |
| Discovery year: |
1994-06-09 |
| GenBank acession: |
X73478 |
| Entrez gene record: |
5524 |
| Pubmed identfication: |
8530035 16380387 |
| RefSeq identity: |
NM_021131 |
| Classification: |
Protein phosphatase 2 modulatory subunits Cyclophilin peptidylprolyl isomerases |
| Havana BLAST/BLAT: |
OTTHUMG00000020774 |