| Category: |
Antibody |
| Concentration: |
pH 7, with 0, 09% sodium azide, 4, In 1X PBS |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
PSME4 / Proteasome Activator Subunit 4 |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
WB |
| Recommended dilutions: |
Western blot: 1:1000-2000 |
| Intented use: |
This PSME4 antibodyis to be used only for research purposes and not for diagnostics |
| Gene ID #: |
23198 |
| Uniprot #: |
Q14997 |
| Purity: |
Antigen affinity |
| Description: |
Also involved in DNA damage response in somatic cells, Binds to the core proteasome via its C-terminus, Component of the spermatoproteasome, Recognizes and binds acetylated histones via its bromodomain-like (BRDL) region and activates the proteasome by opening the gated channel for substrate entry, a form of the proteasome specifically found in testis: binds to acetylated histones and promotes degradation of histones, by promoting degradation of histones following DNA double-strand breaks, opening the closed structure of the proteasome via an active gating mechanism, thereby participating actively to the exchange of histones during spermatogenesis, which occupies the same binding sites as the proteasomal ATPases, Proteasome activator complex subunit 4 is an associated component of the proteasome that specifically recognizes acetylated histones and promotes ATP- and ubiquitin- independent degradation of core histones during spermatogenesis and DNA damage response |
| Immunogen: |
A portion of amino acids 503-535 from the human protein was used as the immunogen for the PSME4 antibody |
| Storage: |
Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the PSME4 antibody and store frozen at -20 deg |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
PSME4 / Proteasome Activator Subunit 4 |
| Short name: |
PSME4 Antibody / Proteasome Activator Subunit 4 |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
macropain) activator subunit 4 (Antibody to) / protein degradation aggregate Activator functionnal sequence 4, proteasome (prosome |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
PA200, PSME4 and IDBG-51780 and ENSG00000068878 and 23198, PSME4 and IDBG-633844 and ENSBTAG00000020262 and 528142, Psme4 and IDBG-158627 and ENSMUSG00000040850 and 103554, TAP-dependent and biological process this GO :0005488 and binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005829 and cytosol and cellular component this GO :0006281 and DNA repair and biological process this GO :0006521 and regulation of cellular amino acid metabolic process and biological process this GO :0006915 and apoptotic process and biological process this GO :0006974 and cellular response to DNA damage stimulus and biological process this GO :0006977 and DNA damage response, exchange of chromosomal proteins and biological process this GO :0042590 and antigen processing and presentation of exogenous peptide antigen via MHC class I and biological process this GO :0042981 and regulation of apoptotic process and biological process this GO :0043066 and negative regulation of apoptotic process and biological process this GO :0044281 and small molecule metabolic process and biological process this GO :0051437 and positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle and biological process this GO :0051439 and regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle and biological process this GO :0070577 and lysine-acetylated histone binding and molecular function this GO :1990111 and spermatoproteasome complex and cellular component, lysine-acetylated histone binding, macropain) activator subunit 4, nuclei, signal transduction by p53 class mediator resulting in cell cycle arrest and biological process this GO :0007275 and multicellular organismal development and biological process this GO :0010467 and gene expression and biological process this GO :0010499 and proteasomal ubiquitin-independent protein catabolic process and biological process this GO :0010952 and positive regulation of peptidase activity and biological process this GO :0016032 and viral process and biological process this GO :0016070 and RNA metabolic process and biological process this GO :0016071 and mRNA metabolic process and biological process this GO :0016504 and peptidase activator activity and molecular function this GO :0016607 and nuclear speck and cellular component this GO :0031145 and anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process and biological process this GO :0034641 and cellular nitrogen compound metabolic process and biological process this GO :0035093 and spermatogenesis, this GO :0000209 and protein polyubiquitination and biological process this GO :0000278 and mitotic cell cycle and biological process this GO :0002474 and antigen processing and presentation of peptide antigen via MHC class I and biological process this GO :0002479 and antigen processing and presentation of exogenous peptide antigen via MHC class I, this GO :0005488 : binding, this GO :0005488 : binding and also this GO :0016504 : peptidase activator activity and also this GO :0070577 : lysine-acetylated histone binding, this GO :0016504 : peptidase activator activity, this GO :0070577 : lysine-acetylated histone binding, proteasome (prosome |
| Identity: |
20635 |
| Gene: |
PSME4 |
More about : PSME4 |
| Long gene name: |
proteasome activator subunit 4 |
| Synonyms gene name: |
macropain) activator subunit 4 , proteasome (prosome |
| Synonyms: |
PA200 KIAA0077 |
| Locus: |
2p16, 2 |
| Discovery year: |
2003-04-14 |
| GenBank acession: |
D38521 |
| Entrez gene record: |
23198 |
| Pubmed identfication: |
7584044 12093752 |
| RefSeq identity: |
XM_040158 |
| Classification: |
Proteasome |
| Havana BLAST/BLAT: |
OTTHUMG00000151852 |