| Category: |
Antibody |
| Concentration: |
pH 7, with 0, 09% sodium azide, 4, In 1X PBS |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
COMMD1 |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
WB |
| Recommended dilutions: |
Western blot: 1:1000-2000 |
| Intented use: |
This COMMD1 antibodyis to be used only for research purposes and not for diagnostics |
| Gene ID #: |
150684 |
| Uniprot #: |
Q8N668 |
| Purity: |
Antigen affinity |
| Description: |
Binds to phosphatidylinositol 4, Can bind one copper ion per monomer, Can modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes by displacing CAND1, Down-regulates NF-kappa-B activity, Down-regulates SOD1 activity by interfering with its homodimerization, Involved in copper-dependent ATP7A trafficking between the trans- Golgi network and vesicles in the cell periphery, Involved in the regulation of HIF1A-mediated transcription, Involved in the regulation of membrane expression and ubiquitination of SLC12A2, May function to facilitate biliary copper excretion within hepatocytes, Modulates Na(+) transport in epithelial cells by regulation of apical cell surface expression of amiloride-sensitive sodium channel (ENaC) subunits and by promoting their ubiquitination presumably involving NEDD4L, Plays a role in copper ion homeostasis, Promotes CFTR cell surface expression through regulation of its ubiquitination, Promotes the localization of SCNN1D to recycling endosomes, Promotes ubiquitination of NF-kappa-B subunit RELA and its subsequent proteasomal degradation, competes with ARNT/Hif-1-beta for binding to HIF1A resulting in decreased DNA binding and impaired transcriptional activation by HIF-1, in vitro promotes CRL E3 activiy and dissocoiates CAND1 from CUL1 and CUL2, the function is proposed to depend on its association within the CCC complex and cooperation with the WASH complex on early endosomes, 5)P2), 5- bisphosphate (PtdIns(4, COMM domain-containing protein 1 is a proposed scaffold protein that is implicated in diverse physiological processes and whose function may be in part linked to its ability to regulate ubiquitination of specific cellular proteins |
| Immunogen: |
A portion of amino acids 4-33 from the human protein was used as the immunogen for the COMMD1 antibody |
| Storage: |
Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the COMMD1 antibody and store frozen at -20 deg |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
COMMD1 |
| Short name: |
COMMD1 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
COMMD1 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
23024 |
| Gene: |
COMMD1 |
More about : COMMD1 |
| Long gene name: |
copper metabolism domain containing 1 |
| Synonyms gene: |
C2orf5 |
| Synonyms gene name: |
chromosome 2 open reading frame 5 (MURR1) copper metabolism (Murr1) domain containing 1 |
| Synonyms: |
MURR1 MGC27155 |
| Synonyms name: |
copper metabolism gene MURR1 COMM domain containing 1 |
| Locus: |
2p15 |
| Discovery year: |
2003-08-26 |
| GenBank acession: |
BC022046 |
| Entrez gene record: |
150684 |
| Pubmed identfication: |
9001233 11809725 |
| RefSeq identity: |
NM_152516 |
| Classification: |
COMM domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000129445 |