| Category: |
Antibody |
| Concentration: |
pH 7, with 0, 09% sodium azide, 4, In 1X PBS |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
IGF2R / M6PR |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
WB |
| Recommended dilutions: |
Western blot: 1:1000-2000 |
| Intented use: |
This IGF2R antibodyis to be used only for research purposes and not for diagnostics |
| Gene ID #: |
3482 |
| Uniprot #: |
P11717 |
| Purity: |
Antigen affinity |
| Description: |
Acts as a positive regulator of T-cell coactivation, Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6- phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex, This receptor also binds IGF2, by binding DPP4, Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes |
| Immunogen: |
A portion of amino acids 2424-2458 from the human protein was used as the immunogen for the IGF2R antibody |
| Storage: |
Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the IGF2R antibody and store frozen at -20 deg |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
IGF2R / M6PR |
| Short name: |
IGF2R Antibody / M6PR |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
insulin-like growth factor 2 receptor (Antibody to) / mannose-6-phosphate receptor (cation dependent) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
BT, CD-MPR and MPR 46 and MPR-46 and MPR46 and SMPR, CD222 and CIMPR and M6P-R and MPR1 and MPRI, IGF2R and IDBG-98588 and ENSG00000197081 and 3482, Igf2r and IDBG-136984 and ENSMUSG00000023830 and 16004, M6PR and IDBG-17511 and ENSG00000003056 and 4074, M6PR and IDBG-639695 and ENSBTAG00000018207 and 281291, M6pr and IDBG-185276 and ENSMUSG00000007458 and 17113, Plasma membranes, insulin-like growth factor 2 receptor, mannose transmembrane transporter activity, nuclei, phosphoprotein binding, this GO :0000323 and lytic vacuole and cellular component this GO :0004888 and transmembrane signaling receptor activity and molecular function this GO :0005537 and mannose binding and molecular function this GO :0005765 and lysosomal membrane and cellular component this GO :0005768 and endosome and cellular component this GO :0005770 and late endosome and cellular component this GO :0005887 and integral component of plasma membrane and cellular component this GO :0006898 and receptor-mediated endocytosis and biological process this GO :0007165 and signal transduction and biological process this GO :0008333 and endosome to lysosome transport and biological process this GO :0015578 and mannose transmembrane transporter activity and molecular function this GO :0015761 and mannose transport and biological process this GO :0016020 and membrane and cellular component this GO :0016021 and integral component of membrane and cellular component, this GO :0001889 and liver development and biological process this GO :0001948 and glycoprotein binding and molecular function this GO :0001965 and G-protein alpha-subunit binding and molecular function this GO :0001972 and retinoic acid binding and molecular function this GO :0004872 and receptor activity and molecular function this GO :0004930 and G-protein coupled receptor activity and molecular function this GO :0005010 and insulin-like growth factor-activated receptor activity and molecular function this GO :0005215 and transporter activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005520 and insulin-like growth factor binding and molecular function this GO :0005537 and mannose binding and molecular function this GO :0005615 and extracellular space and cellular component this GO :0005634 and nucleus and cellular component this GO :0005641 and nuclear envelope lumen and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005765 and lysosomal membrane and cellular component this GO :0005768 and endosome and cellular component this GO :0005770 and late endosome and cellular component this GO :0005802 and trans- this GO lgi network and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0005887 and integral component of plasma membrane and cellular component this GO :0006810 and transport and biological process this GO :0006898 and receptor-mediated endocytosis and biological process this GO :0007165 and signal transduction and biological process this GO :0007186 and G-protein coupled receptor signaling pathway and biological process this GO :0007283 and spermatogenesis and biological process this GO :0009791 and post-embryonic development and biological process this GO :0009986 and cell surface and cellular component this GO :0016020 and membrane and cellular component this GO :0016021 and integral component of membrane and cellular component this GO :0019899 and enzyme binding and molecular function this GO :0030118 and clathrin coat and cellular component this GO :0030139 and endocytic vesicle and cellular component this GO :0030140 and trans- this GO lgi network transport vesicle and cellular component this GO :0031100 and organ regeneration and biological process this GO :0031995 and insulin-like growth factor II binding and molecular function this GO :0032526 and response to retinoic acid and biological process this GO :0042802 and identical protein binding and molecular function this GO :0042981 and regulation of apoptotic process and biological process this GO :0043065 and positive regulation of apoptotic process and biological process this GO :0048009 and insulin-like growth factor receptor signaling pathway and biological process this GO :0048471 and perinuclear region of cytoplasm and cellular component this GO :0051219 and phosphoprotein binding and molecular function this GO :0070062 and extracellular vesicular exosome and cellular component, this GO :0001948 : glycoprotein binding, this GO :0001948 : glycoprotein binding and also this GO :0001965 : G-protein alpha-subunit binding and also this GO :0001972 : retinoic acid binding and also this GO :0004872 : receptor activity and also this GO :0004930 : G-protein coupled receptor activity and also this GO :0005010 : insulin-like growth factor-activated receptor activity and also this GO :0005215 : transporter activity and also this GO :0005515 : protein binding and also this GO :0005520 : insulin-like growth factor binding and also this GO :0005537 : mannose binding and also this GO :0019899 : enzyme binding and also this GO :0031995 : insulin-like growth factor II binding and also this GO :0042802 : identical protein binding and also this GO :0051219 : phosphoprotein binding, this GO :0001965 : G-protein alpha-subunit binding, this GO :0001972 : retinoic acid binding, this GO :0004872 : receptor activity, this GO :0004888 : transmembrane signaling receptor activity, this GO :0004888 : transmembrane signaling receptor activity and also this GO :0005537 : mannose binding and also this GO :0015578 : mannose transmembrane transporter activity, this GO :0004930 : G-protein coupled receptor activity, this GO :0005010 : insulin-like growth factor-activated receptor activity, this GO :0005215 : transporter activity, this GO :0005515 : protein binding, this GO :0005520 : insulin-like growth factor binding, this GO :0005537 : mannose binding, this GO :0005537 : mannose binding, this GO :0015578 : mannose transmembrane transporter activity, this GO :0019899 : enzyme binding, this GO :0031995 : insulin-like growth factor II binding, this GO :0042802 : identical protein binding, this GO :0051219 : phosphoprotein binding, 4977 and IDBG-635488 and ENSBTAG00000002402 and 281849, mannose-6-phosphate receptor (cation dependent) |
| Identity: |
5467 |
| Gene: |
IGF2R |
More about : IGF2R |
| Long gene name: |
insulin like growth factor 2 receptor |
| Synonyms gene name: |
insulin-like growth factor 2 receptor |
| Synonyms: |
CD222 MPRI MPR1 CIMPR M6P-R CI-M6PR CI-MPR MPR300 |
| Synonyms name: |
cation-independent mannose-6 phosphate receptor |
| Locus: |
6q25, 3 |
| Discovery year: |
1988-07-07 |
| GenBank acession: |
J03528 |
| Entrez gene record: |
3482 |
| RefSeq identity: |
NM_000876 |
| Classification: |
CD molecules MRH domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000015945 |
| Locus Specific Databases: |
LRG_1036 |