| Category: |
Antibody |
| Concentration: |
pH 7, with 0, 09% sodium azide, 4, In 1X PBS |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
FBXW7 |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
ELISA, WB |
| Recommended dilutions: |
Western blot: 1:2000 |
| Notes: |
Titration of the FBXW7 antibody may be required due to differences in protocols and secondary/substrate sensitivity |
| Intented use: |
This FBXW7 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
Q969H0 |
| Purity: |
Antigen affinity |
| Description: |
Identified substrates include cyclin-E, MYC, NOTCH1 released notch intracellular domain (NICD), Recognizes and binds phosphorylated sites/phosphodegrons within target proteins and thereafter bring them to the SCF complex for ubiquitination, [UniProt], and probably PSEN1, Substrate recognition component of an SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins |
| Immunogen: |
This FBXW7 antibody was produced from a rabbit immunized with a KLH conjugated synthetic peptide between 177-208 amino acids from the N-terminal region of human FBXW7 |
| Storage: |
Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the FBXW7 antibody and store frozen at -20 deg |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
FBXW7 |
| Short name: |
FBXW7 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
FBXW7 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
16712 |
| Gene: |
FBXW7 |
More about : FBXW7 |
| Long gene name: |
F-box and WD repeat domain containing 7 |
| Synonyms gene name: |
Drosophila) F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase , F-box and WD-40 domain protein 7 (archipelago homolog |
| Synonyms: |
AGO FLJ11071 SEL-10 SEL10 FBW7 FBX30 CDC4 FBXW6 |
| Synonyms name: |
archipelago homolog (Drosophila) |
| Locus: |
4q31, 3 |
| Discovery year: |
2001-12-20 |
| GenBank acession: |
AF411971 |
| Entrez gene record: |
55294 |
| Pubmed identfication: |
10531037 11425854 |
| Classification: |
F-box and WD repeat domain containing WD repeat domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000185246 |