| Category: |
Antibody |
| Concentration: |
pH 7, with 0, 09% sodium azide, 4, In 1X PBS |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
Cyclin D3 (CCND3) |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus), Rat , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
ELISA, WB |
| Recommended dilutions: |
Western blot: 1:500-1:1000 |
| Notes: |
Titration of the Cyclin D3 antibody may be required due to differences in protocols and secondary/substrate sensitivity |
| Intented use: |
This Cyclin D3 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
P48961 |
| Purity: |
Antigen affinity |
| Description: |
Also substrate for SMAD3, Component of the ternary complex, Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals, Hypophosphorylates RB1 in early G(1) phase, Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase, cyclin D3/CDK4/CDKN1B, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity, required for nuclear translocation and activity of the cyclin D-CDK4 complex, Regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition |
| Immunogen: |
This Cyclin D3 antibody was produced from a rabbit immunized with a KLH conjugated synthetic peptide between 33-66 amino acids from the N-terminal region of rat Ccnd3 |
| Storage: |
Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the Cyclin D3 antibody and store frozen at -20 deg |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
Cyclin D3 (CCND3) |
| Short name: |
Cyclin D3 Antibody (CCND3) |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
Cyclin D3 (Antibody to) (cyclin D3) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
BT, CCND3 and IDBG-86973 and ENSG00000112576 and 896, Ccnd3 and IDBG-189288 and ENSMUSG00000034165 and 12445, nuclei, protein kinase binding, this GO :0000079 and regulation of cyclin-dependent protein serine/threonine kinase activity and biological process this GO :0000307 and cyclin-dependent protein kinase holoenzyme complex and cellular component this GO :0001934 and positive regulation of protein phosphorylation and biological process this GO :0004693 and cyclin-dependent protein serine/threonine kinase activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0006468 and protein phosphorylation and biological process this GO :0007049 and cell cycle and biological process this GO :0007165 and signal transduction and biological process this GO :0016020 and membrane and cellular component this GO :0019901 and protein kinase binding and molecular function this GO :0042098 and T cell proliferation and biological process this GO :0045737 and positive regulation of cyclin-dependent protein serine/threonine kinase activity and biological process this GO :0051301 and cell division and biological process this GO :0051726 and regulation of cell cycle and biological process, this GO :0004693 : cyclin-dependent protein serine/threonine kinase activity, this GO :0004693 : cyclin-dependent protein serine/threonine kinase activity and also this GO :0005515 : protein binding and also this GO :0019901 : protein kinase binding, this GO :0005515 : protein binding, this GO :0019901 : protein kinase binding, 29057 and IDBG-631016 and ENSBTAG00000010106 and 540547, cyclin D3 |
| Identity: |
1585 |
| Gene: |
CCND3 |
More about : CCND3 |
| Long gene name: |
cyclin D3 |
| Locus: |
6p21, 1 |
| Discovery year: |
1991-12-10 |
| Entrez gene record: |
896 |
| Pubmed identfication: |
1386335 |
| RefSeq identity: |
NM_001760 |
| Classification: |
Cyclins |
| Havana BLAST/BLAT: |
OTTHUMG00000014690 |
| Locus Specific Databases: |
LRG_998 |