| Category: |
Antibody |
| Concentration: |
09% sodium azide, 4 with 0, In 1X PBS pH 7 |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
HER2 (ERBB2) (phospho-Y1222) |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
ELISA, WB |
| Recommended dilutions: |
Western blot: 1:1000 |
| Notes: |
Titration of the phospho-ErbB2 antibody may be required due to differences in protocols and secondary/substrate sensitivity |
| Intented use: |
This phospho-ErbB2 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
P04626 |
| Purity: |
Antigen affinity |
| Description: |
Associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription, Essential component of a neuregulin-receptor complex, GP30 is a potential ligand for this receptor, Implicated in transcriptional activation of CDKN1A, In the nucleus is involved in transcriptional regulation, In turn, Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth, Regulates outgrowth and stabilization of peripheral microtubules (MTs), This prevents the phosphorylation of APC and CLASP2, Upon ERBB2 activation, allowing its association with the cell membrane, although neuregulins do not interact with it alone, but that apparently needs a coreceptor for ligand binding, membrane-bound APC allows the localization of MACF1 to the cell membrane, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane, the function involves STAT3 and SRC, which is required for microtubule capture and stabilization, Protein tyrosine kinase that is part of several cell surface receptor complexes |
| Immunogen: |
This phospho-ErbB2 antibody was produced from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding pY1222 of the human protein |
| Storage: |
Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the phospho-ErbB2 antibody and store frozen at -20 deg |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
HER2 (ERBB2) (phospho-Y1222) |
| Short name: |
HER2 Antibody (ERBB2) (phospho-Y1222) |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
neuro/glioblastoma derived oncogene homolog (avian)) (phosphorilated-Y1222), HER2 (Antibody to) (v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
CD340 and HER-2 and HER-2/neu and HER2 and MLN 19 and NEU and NGL and TKR1, DNA-templated and biological process this GO :0006468 and protein phosphorylation and biological process this GO :0007165 and signal transduction and biological process this GO :0007166 and cell surface receptor signaling pathway and biological process this GO :0007167 and enzyme linked receptor protein signaling pathway and biological process this GO :0007169 and transmembrane receptor protein tyrosine kinase signaling pathway and biological process this GO :0007173 and epidermal growth factor receptor signaling pathway and biological process this GO :0007399 and nervous system development and biological process this GO :0007411 and axon guidance and biological process this GO :0007422 and peripheral nervous system development and biological process this GO :0007507 and heart development and biological process this GO :0007528 and neuromuscular junction development and biological process this GO :0008022 and protein C-terminus binding and molecular function this GO :0008045 and motor neuron axon guidance and biological process this GO :0008283 and cell proliferation and biological process this GO :0008543 and fibroblast growth factor receptor signaling pathway and biological process this GO :0010008 and endosome membrane and cellular component this GO :0014065 and phosphatidylinositol 3-kinase signaling and biological process this GO :0016020 and membrane and cellular component this GO :0016021 and integral component of membrane and cellular component this GO :0016323 and basolateral plasma membrane and cellular component this GO :0016324 and apical plasma membrane and cellular component this GO :0016772 and transferase activity, ERBB2 and IDBG-46068 and ENSG00000141736 and 2064, ERBB2 and IDBG-639410 and ENSBTAG00000021798 and 505709, Erbb2 and IDBG-210591 and ENSMUSG00000062312 and 13866, neuro/glioblastoma derived oncogene homolog (avian), nuclei, this GO :0001042 and RNA polymerase I core binding and molecular function this GO :0001934 and positive regulation of protein phosphorylation and biological process this GO :0004672 and protein kinase activity and molecular function this GO :0004713 and protein tyrosine kinase activity and molecular function this GO :0004714 and transmembrane receptor protein tyrosine kinase activity and molecular function this GO :0004716 and receptor signaling protein tyrosine kinase activity and molecular function this GO :0004888 and transmembrane signaling receptor activity and molecular function this GO :0005006 and epidermal growth factor-activated receptor activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005524 and ATP binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0006351 and transcription, this GO :0001042 : RNA polymerase I core binding, this GO :0001042 : RNA polymerase I core binding and also this GO :0004672 : protein kinase activity and also this GO :0004713 : protein tyrosine kinase activity and also this GO :0004714 : transmembrane receptor protein tyrosine kinase activity and also this GO :0004716 : receptor signaling protein tyrosine kinase activity and also this GO :0004888 : transmembrane signaling receptor activity and also this GO :0005006 : epidermal growth factor-activated receptor activity and also this GO :0005515 : protein binding and also this GO :0005524 : ATP binding and also this GO :0008022 : protein C-terminus binding and also this GO :0016772 : transferase activity, this GO :0004672 : protein kinase activity, this GO :0004713 : protein tyrosine kinase activity, this GO :0004714 : transmembrane receptor protein tyrosine kinase activity, this GO :0004716 : receptor signaling protein tyrosine kinase activity, this GO :0004888 : transmembrane signaling receptor activity, this GO :0005006 : epidermal growth factor-activated receptor activity, this GO :0005515 : protein binding, this GO :0005524 : ATP binding, this GO :0008022 : protein C-terminus binding, this GO :0016772 : transferase activity, this GO :0019838 : growth factor binding, this GO :0019903 : protein phosphatase binding, this GO :0042802 : identical protein binding, this GO :0043125 : ErbB-3 class receptor binding, this GO :0046982 : protein heterodimerization activity, this GO :0046983 : protein dimerization activity, transferase activity, transferring phosphorus-containing groups, transferring phosphorus-containing groups and also this GO :0019838 : growth factor binding and also this GO :0019903 : protein phosphatase binding and also this GO :0042802 : identical protein binding and also this GO :0043125 : ErbB-3 class receptor binding and also this GO :0046982 : protein heterodimerization activity and also this GO :0046983 : protein dimerization activity, transferring phosphorus-containing groups and molecular function this GO :0018108 and peptidyl-tyrosine phosphorylation and biological process this GO :0019838 and growth factor binding and molecular function this GO :0019903 and protein phosphatase binding and molecular function this GO :0023014 and signal transduction by phosphorylation and biological process this GO :0030307 and positive regulation of cell growth and biological process this GO :0030879 and mammary gland development and biological process this GO :0031410 and cytoplasmic vesicle and cellular component this GO :0032321 and positive regulation of Rho GTPase activity and biological process this GO :0032886 and regulation of microtubule-based process and biological process this GO :0033088 and negative regulation of immature T cell proliferation in thymus and biological process this GO :0038095 and Fc-epsilon receptor signaling pathway and biological process this GO :0042060 and wound healing and biological process this GO :0042552 and myelination and biological process this GO :0042802 and identical protein binding and molecular function this GO :0043125 and ErbB-3 class receptor binding and molecular function this GO :0043235 and receptor complex and cellular component this GO :0043406 and positive regulation of MAP kinase activity and biological process this GO :0045087 and innate immune response and biological process this GO :0045727 and positive regulation of translation and biological process this GO :0045765 and regulation of angiogenesis and biological process this GO :0045785 and positive regulation of cell adhesion and biological process this GO :0045943 and positive regulation of transcription from RNA polymerase I promoter and biological process this GO :0045945 and positive regulation of transcription from RNA polymerase III promoter and biological process this GO :0046777 and protein autophosphorylation and biological process this GO :0046982 and protein heterodimerization activity and molecular function this GO :0046983 and protein dimerization activity and molecular function this GO :0048011 and neurotrophin TRK receptor signaling pathway and biological process this GO :0048015 and phosphatidylinositol-mediated signaling and biological process this GO :0048471 and perinuclear region of cytoplasm and cellular component this GO :0048709 and oli this GO dendrocyte differentiation and biological process this GO :0050679 and positive regulation of epithelial cell proliferation and biological process this GO :0070372 and regulation of ERK1 and ERK2 cascade and biological process, v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 |
| Identity: |
3430 |
| Gene: |
ERBB2 |
More about : ERBB2 |
| Long gene name: |
erb-b2 receptor tyrosine kinase 2 |
| Synonyms gene: |
NGL |
| Synonyms gene name: |
v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog) v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 |
| Synonyms: |
NEU HER-2 CD340 HER2 |
| Synonyms name: |
neuro/glioblastoma derived oncogene homolog human epidermal growth factor receptor 2 |
| Locus: |
17q12 |
| Discovery year: |
2001-06-22 |
| GenBank acession: |
X03363 |
| Entrez gene record: |
2064 |
| RefSeq identity: |
NM_004448 |
| Classification: |
CD molecules Minor histocompatibility antigens Erb-b2 receptor tyrosine kinases |
| Havana BLAST/BLAT: |
OTTHUMG00000179300 |
| Locus Specific Databases: |
LRG_724 |