| Category: |
Antibody |
| Concentration: |
09% sodium azide, 4 with 0, In 1X PBS pH 7 |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
HER2 (ERBB2) (phospho-S1107) |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
ELISA, WB, DB |
| Recommended dilutions: |
Dot blot: 1:500, Western blot: 1:1000 |
| Notes: |
Titration of the phospho-HER2 antibody may be required due to differences in protocols and secondary/substrate sensitivity |
| Intented use: |
This phospho-HER2 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
P04626 |
| Purity: |
Antigen affinity |
| Description: |
Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, Alternative splicing results in several additional transcript variants, Amplification and/or overexpression of this gene has been reported in numerous cancers, However, Ile654/Ile655, This protein has no ligand binding domain of its own and therefore cannot bind growth factors, including breast and ovarian tumors, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, shown here, some encoding different isoforms and others that have not been fully characterized, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase, with the most common allele, This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases |
| Immunogen: |
This phospho-HER2 antibody was produced from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding pS1107 of human HER2/ERBB2 |
| Storage: |
Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the phospho-HER2 antibody and store frozen at -20 deg |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
HER2 (ERBB2) (phospho-S1107) |
| Short name: |
HER2 Antibody (ERBB2) (phospho-S1107) |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
neuro/glioblastoma derived oncogene homolog (avian)) (phosphorilated-S1107), HER2 (Antibody to) (v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
CD340 and HER-2 and HER-2/neu and HER2 and MLN 19 and NEU and NGL and TKR1, DNA-templated and biological process this GO :0006468 and protein phosphorylation and biological process this GO :0007165 and signal transduction and biological process this GO :0007166 and cell surface receptor signaling pathway and biological process this GO :0007167 and enzyme linked receptor protein signaling pathway and biological process this GO :0007169 and transmembrane receptor protein tyrosine kinase signaling pathway and biological process this GO :0007173 and epidermal growth factor receptor signaling pathway and biological process this GO :0007399 and nervous system development and biological process this GO :0007411 and axon guidance and biological process this GO :0007422 and peripheral nervous system development and biological process this GO :0007507 and heart development and biological process this GO :0007528 and neuromuscular junction development and biological process this GO :0008022 and protein C-terminus binding and molecular function this GO :0008045 and motor neuron axon guidance and biological process this GO :0008283 and cell proliferation and biological process this GO :0008543 and fibroblast growth factor receptor signaling pathway and biological process this GO :0010008 and endosome membrane and cellular component this GO :0014065 and phosphatidylinositol 3-kinase signaling and biological process this GO :0016020 and membrane and cellular component this GO :0016021 and integral component of membrane and cellular component this GO :0016323 and basolateral plasma membrane and cellular component this GO :0016324 and apical plasma membrane and cellular component this GO :0016772 and transferase activity, ERBB2 and IDBG-46068 and ENSG00000141736 and 2064, ERBB2 and IDBG-639410 and ENSBTAG00000021798 and 505709, Erbb2 and IDBG-210591 and ENSMUSG00000062312 and 13866, neuro/glioblastoma derived oncogene homolog (avian), nuclei, this GO :0001042 and RNA polymerase I core binding and molecular function this GO :0001934 and positive regulation of protein phosphorylation and biological process this GO :0004672 and protein kinase activity and molecular function this GO :0004713 and protein tyrosine kinase activity and molecular function this GO :0004714 and transmembrane receptor protein tyrosine kinase activity and molecular function this GO :0004716 and receptor signaling protein tyrosine kinase activity and molecular function this GO :0004888 and transmembrane signaling receptor activity and molecular function this GO :0005006 and epidermal growth factor-activated receptor activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005524 and ATP binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0006351 and transcription, this GO :0001042 : RNA polymerase I core binding, this GO :0001042 : RNA polymerase I core binding and also this GO :0004672 : protein kinase activity and also this GO :0004713 : protein tyrosine kinase activity and also this GO :0004714 : transmembrane receptor protein tyrosine kinase activity and also this GO :0004716 : receptor signaling protein tyrosine kinase activity and also this GO :0004888 : transmembrane signaling receptor activity and also this GO :0005006 : epidermal growth factor-activated receptor activity and also this GO :0005515 : protein binding and also this GO :0005524 : ATP binding and also this GO :0008022 : protein C-terminus binding and also this GO :0016772 : transferase activity, this GO :0004672 : protein kinase activity, this GO :0004713 : protein tyrosine kinase activity, this GO :0004714 : transmembrane receptor protein tyrosine kinase activity, this GO :0004716 : receptor signaling protein tyrosine kinase activity, this GO :0004888 : transmembrane signaling receptor activity, this GO :0005006 : epidermal growth factor-activated receptor activity, this GO :0005515 : protein binding, this GO :0005524 : ATP binding, this GO :0008022 : protein C-terminus binding, this GO :0016772 : transferase activity, this GO :0019838 : growth factor binding, this GO :0019903 : protein phosphatase binding, this GO :0042802 : identical protein binding, this GO :0043125 : ErbB-3 class receptor binding, this GO :0046982 : protein heterodimerization activity, this GO :0046983 : protein dimerization activity, transferase activity, transferring phosphorus-containing groups, transferring phosphorus-containing groups and also this GO :0019838 : growth factor binding and also this GO :0019903 : protein phosphatase binding and also this GO :0042802 : identical protein binding and also this GO :0043125 : ErbB-3 class receptor binding and also this GO :0046982 : protein heterodimerization activity and also this GO :0046983 : protein dimerization activity, transferring phosphorus-containing groups and molecular function this GO :0018108 and peptidyl-tyrosine phosphorylation and biological process this GO :0019838 and growth factor binding and molecular function this GO :0019903 and protein phosphatase binding and molecular function this GO :0023014 and signal transduction by phosphorylation and biological process this GO :0030307 and positive regulation of cell growth and biological process this GO :0030879 and mammary gland development and biological process this GO :0031410 and cytoplasmic vesicle and cellular component this GO :0032321 and positive regulation of Rho GTPase activity and biological process this GO :0032886 and regulation of microtubule-based process and biological process this GO :0033088 and negative regulation of immature T cell proliferation in thymus and biological process this GO :0038095 and Fc-epsilon receptor signaling pathway and biological process this GO :0042060 and wound healing and biological process this GO :0042552 and myelination and biological process this GO :0042802 and identical protein binding and molecular function this GO :0043125 and ErbB-3 class receptor binding and molecular function this GO :0043235 and receptor complex and cellular component this GO :0043406 and positive regulation of MAP kinase activity and biological process this GO :0045087 and innate immune response and biological process this GO :0045727 and positive regulation of translation and biological process this GO :0045765 and regulation of angiogenesis and biological process this GO :0045785 and positive regulation of cell adhesion and biological process this GO :0045943 and positive regulation of transcription from RNA polymerase I promoter and biological process this GO :0045945 and positive regulation of transcription from RNA polymerase III promoter and biological process this GO :0046777 and protein autophosphorylation and biological process this GO :0046982 and protein heterodimerization activity and molecular function this GO :0046983 and protein dimerization activity and molecular function this GO :0048011 and neurotrophin TRK receptor signaling pathway and biological process this GO :0048015 and phosphatidylinositol-mediated signaling and biological process this GO :0048471 and perinuclear region of cytoplasm and cellular component this GO :0048709 and oli this GO dendrocyte differentiation and biological process this GO :0050679 and positive regulation of epithelial cell proliferation and biological process this GO :0070372 and regulation of ERK1 and ERK2 cascade and biological process, v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 |
| Identity: |
3430 |
| Gene: |
ERBB2 |
More about : ERBB2 |
| Long gene name: |
erb-b2 receptor tyrosine kinase 2 |
| Synonyms gene: |
NGL |
| Synonyms gene name: |
v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog) v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 |
| Synonyms: |
NEU HER-2 CD340 HER2 |
| Synonyms name: |
neuro/glioblastoma derived oncogene homolog human epidermal growth factor receptor 2 |
| Locus: |
17q12 |
| Discovery year: |
2001-06-22 |
| GenBank acession: |
X03363 |
| Entrez gene record: |
2064 |
| RefSeq identity: |
NM_004448 |
| Classification: |
CD molecules Minor histocompatibility antigens Erb-b2 receptor tyrosine kinases |
| Havana BLAST/BLAT: |
OTTHUMG00000179300 |
| Locus Specific Databases: |
LRG_724 |