| Category: |
Antibody |
| Concentration: |
pH 7, with 0, 09% sodium azide, 4, In 1X PBS |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
Anti-p21 |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Mouse (Mus musculus) |
| Tested applications: |
ELISA, WB |
| Recommended dilutions: |
Western blot: 1:1000 |
| Notes: |
Titration of the anti-p21 antibody may be required due to differences in protocols and secondary/substrate sensitivity |
| Intented use: |
This anti-p21 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
P39689 |
| Purity: |
Antigen affinity |
| Description: |
At higher stoichiometric ratios, Binds to and inhibits cyclin-dependent kinase activity, Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1, inhibits the kinase activity of the cyclin D-CDK4 complex (By similarity), preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression, May be the important intermediate by which p53/TP53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage |
| Immunogen: |
A portion of amino acids 126-154 from the mouse protein was used as the immunogen for this anti-p21 antibody |
| Storage: |
Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the anti-p21 antibody and store frozen at -20 deg |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
p21 |
| Short name: |
Anti-p21 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
antibody to-p21 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
8591 |
| Gene: |
PAK2 |
More about : PAK2 |
| Long gene name: |
p21 (RAC1) activated kinase 2 |
| Synonyms gene name: |
p21 (CDKN1A)-activated kinase 2 p21 protein (Cdc42/Rac)-activated kinase 2 |
| Synonyms: |
PAK65 PAKgamma |
| Synonyms name: |
S6/H4 kinase |
| Locus: |
3q29 |
| Discovery year: |
1998-03-25 |
| GenBank acession: |
U24153 |
| Entrez gene record: |
5062 |
| Pubmed identfication: |
7744004 7618083 |
| RefSeq identity: |
NM_002577 |
| Havana BLAST/BLAT: |
OTTHUMG00000155534 |