| Category: |
Antibody |
| Concentration: |
pH 7, with 0, 09% sodium azide, 4, In 1X PBS |
| Form: |
Purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
DDR2 |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
ELISA, FACS, IHC, WB |
| Recommended dilutions: |
Flow Cytometry: 1:10-1:50, IHC (Paraffin): 1:10-1:50, Western blot: 1:1000 |
| Notes: |
Titration of the DDR2 antibody may be required due to differences in protocols and secondary/substrate sensitivity |
| Intented use: |
This DDR2 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
Q16832 |
| Purity: |
Purified |
| Description: |
MMP2 and MMP13, Promotes fibroblast migration and proliferation, Regulates osteoblast differentiation and chondrocyte maturation via a signaling pathway that involves MAP kinases and leads to the activation of the transcription factor RUNX2, Regulates remodeling of the extracellular matrix by up-regulation of the collagenases MMP1, Required for normal bone development, [UniProt], and thereby contributes to cutaneous wound healing, and thereby facilitates cell migration and tumor cell invasion, cell migration and cell proliferation, remodeling of the extracellular matrix, DDR2/TYRO10 is a tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell differentiation |
| Immunogen: |
This DDR2 antibody was produced from rabbits immunized with a his tag recombinant protein of human DDR2/TYRO10 |
| Storage: |
Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the DDR2 antibody and store frozen at -20 deg |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
DDR2 |
| Short name: |
DDR2 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
discoidin domain receptor tyrosine kinase 2 (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
BT, DDR2 and IDBG-104396 and ENSG00000162733 and 4921, Ddr2 and IDBG-203608 and ENSMUSG00000026674 and 18214, MIG20a and NTRKR3 and TKT and TYRO10, Plasma membranes, this GO :0001503 and ossification and biological process this GO :0003416 and endochondral bone growth and biological process this GO :0004672 and protein kinase activity and molecular function this GO :0004713 and protein tyrosine kinase activity and molecular function this GO :0004714 and transmembrane receptor protein tyrosine kinase activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005518 and collagen binding and molecular function this GO :0005524 and ATP binding and molecular function this GO :0005886 and plasma membrane and cellular component this GO :0005887 and integral component of plasma membrane and cellular component this GO :0006468 and protein phosphorylation and biological process this GO :0007155 and cell adhesion and biological process this GO :0007165 and signal transduction and biological process this GO :0007169 and transmembrane receptor protein tyrosine kinase signaling pathway and biological process this GO :0008284 and positive regulation of cell proliferation and biological process this GO :0010715 and regulation of extracellular matrix disassembly and biological process this GO :0010763 and positive regulation of fibroblast migration and biological process this GO :0016324 and apical plasma membrane and cellular component this GO :0016772 and transferase activity, this GO :0004672 : protein kinase activity, this GO :0004672 : protein kinase activity and also this GO :0004713 : protein tyrosine kinase activity and also this GO :0004714 : transmembrane receptor protein tyrosine kinase activity and also this GO :0005515 : protein binding and also this GO :0005518 : collagen binding and also this GO :0005524 : ATP binding and also this GO :0016772 : transferase activity, this GO :0004713 : protein tyrosine kinase activity, this GO :0004714 : transmembrane receptor protein tyrosine kinase activity, this GO :0005515 : protein binding, this GO :0005518 : collagen binding, this GO :0005524 : ATP binding, this GO :0016772 : transferase activity, this GO :0038062 : protein tyrosine kinase collagen receptor activity, transferase activity, transferring phosphorus-containing groups, transferring phosphorus-containing groups and also this GO :0038062 : protein tyrosine kinase collagen receptor activity, transferring phosphorus-containing groups and molecular function this GO :0018108 and peptidyl-tyrosine phosphorylation and biological process this GO :0030198 and extracellular matrix organization and biological process this GO :0030199 and collagen fibril organization and biological process this GO :0030500 and regulation of bone mineralization and biological process this GO :0031214 and biomineral tissue development and biological process this GO :0035988 and chondrocyte proliferation and biological process this GO :0038062 and protein tyrosine kinase collagen receptor activity and molecular function this GO :0038063 and collagen-activated tyrosine kinase receptor signaling pathway and biological process this GO :0045669 and positive regulation of osteoblast differentiation and biological process this GO :0045860 and positive regulation of protein kinase activity and biological process this GO :0046777 and protein autophosphorylation and biological process this GO :0048146 and positive regulation of fibroblast proliferation and biological process this GO :0051091 and positive regulation of sequence-specific DNA binding transcription factor activity and biological process this GO :0070062 and extracellular vesicular exosome and cellular component this GO :0090091 and positive regulation of extracellular matrix disassembly and biological process, 46641 and IDBG-629865 and ENSBTAG00000004885 and 533523, discoidin domain receptor tyrosine kinase 2 |
| Identity: |
2731 |
| Gene: |
DDR2 |
More about : DDR2 |
| Long gene name: |
discoidin domain receptor tyrosine kinase 2 |
| Synonyms gene: |
TYRO10 NTRKR3 |
| Synonyms gene name: |
discoidin domain receptor family, member 2 |
| Synonyms: |
TKT |
| Locus: |
1q23, 3 |
| Discovery year: |
1999-06-17 |
| GenBank acession: |
AK095975 |
| Entrez gene record: |
4921 |
| Pubmed identfication: |
9659899 |
| RefSeq identity: |
NM_006182 |
| Classification: |
Receptor Tyrosine Kinases |
| Havana BLAST/BLAT: |
OTTHUMG00000034423 |