| Category: |
Antibody |
| Concentration: |
pH 7, with 0, 09% sodium azide, 4, In 1X PBS |
| Form: |
Purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
Platelet Derived Growth Factor Receptor beta (PDGFRB) |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
ELISA, FACS, IF, WB, IHC |
| Recommended dilutions: |
Flow Cytometry: 1:10-1:50, IHC (Paraffin): 1:10-1:50, Immunofluorescence: 1:10-1:50, Western blot: 1:1000 |
| Notes: |
Titration of the PDGFR beta antibody may be required due to differences in protocols and secondary/substrate sensitivity, The stated application concentrations are suggested starting amounts |
| Intented use: |
This PDGFR beta antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
P09619 |
| Purity: |
Purified |
| Description: |
A translocation between chromosomes 5 and 12, ETS, The gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor, The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, These growth factors are mitogens for cells of mesenchymal origin, all three genes may be implicated in the 5-q syndrome, composed of both platelet-derived growth factor receptor alpha and beta polypeptides, leukemia gene, results in chronic myelomonocytic leukemia, that fuses the gene to that of the translocation, PDGFRB is a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family |
| Immunogen: |
A portion of amino acids 40-72 from the human protein was used as the immunogen for this CD140b / PDGFR beta antibody |
| Storage: |
Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, For long term, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot the PDGFR beta antibody and store frozen at -20 deg, Store at 4oC for up to one month |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
Platelet Derived Growth Factor Receptor beta (PDGFRB) |
| Short name: |
Platelet Derived Growth Factor Receptor beta Antibody (PDGFRB) |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
b polypeptide), Platelet Derived Growth Factor Receptor b (Antibody to) (platelet-derived growth factor receptor |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
BT, CD140B and IBGC4 and IMF1 and JTK12 and PDGFR and PDGFR-1 and PDGFR1, PDGFRB and IDBG-53326 and ENSG00000113721 and 5159, Pdgfrb and IDBG-150834 and ENSMUSG00000024620 and 18596, beta polypeptide, nuclei, this GO :0001701 and in utero embryonic development and biological process this GO :0001822 and kidney development and biological process this GO :0001894 and tissue homeostasis and biological process this GO :0004672 and protein kinase activity and molecular function this GO :0004713 and protein tyrosine kinase activity and molecular function this GO :0004714 and transmembrane receptor protein tyrosine kinase activity and molecular function this GO :0004871 and signal transducer activity and molecular function this GO :0004992 and platelet activating factor receptor activity and molecular function this GO :0005017 and platelet-derived growth factor-activated receptor activity and molecular function this GO :0005019 and platelet-derived growth factor beta-receptor activity and molecular function this GO :0005102 and receptor binding and molecular function this GO :0005161 and platelet-derived growth factor receptor binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005524 and ATP binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0006024 and glycosaminoglycan biosynthetic process and biological process this GO :0006468 and protein phosphorylation and biological process this GO :0006807 and nitrogen compound metabolic process and biological process this GO :0007165 and signal transduction and biological process this GO :0007169 and transmembrane receptor protein tyrosine kinase signaling pathway and biological process this GO :0007173 and epidermal growth factor receptor signaling pathway and biological process this GO :0007186 and G-protein coupled receptor signaling pathway and biological process this GO :0008284 and positive regulation of cell proliferation and biological process this GO :0008543 and fibroblast growth factor receptor signaling pathway and biological process this GO :0009636 and response to toxic substance and biological process this GO :0009986 and cell surface and cellular component this GO :0010863 and positive regulation of phospholipase C activity and biological process this GO :0014068 and positive regulation of phosphatidylinositol 3-kinase signaling and biological process this GO :0014070 and response to organic cyclic compound and biological process this GO :0014911 and positive regulation of smooth muscle cell migration and biological process this GO :0016020 and membrane and cellular component this GO :0016021 and integral component of membrane and cellular component this GO :0016023 and cytoplasmic membrane-bounded vesicle and cellular component this GO :0016301 and kinase activity and molecular function this GO :0016324 and apical plasma membrane and cellular component this GO :0016477 and cell migration and biological process this GO :0016772 and transferase activity, this GO :0004672 : protein kinase activity, this GO :0004672 : protein kinase activity and also this GO :0004713 : protein tyrosine kinase activity and also this GO :0004714 : transmembrane receptor protein tyrosine kinase activity and also this GO :0004871 : signal transducer activity and also this GO :0004992 : platelet activating factor receptor activity and also this GO :0005017 : platelet-derived growth factor-activated receptor activity and also this GO :0005019 : platelet-derived growth factor beta-receptor activity and also this GO :0005102 : receptor binding and also this GO :0005161 : platelet-derived growth factor receptor binding and also this GO :0005515 : protein binding and also this GO :0005524 : ATP binding and also this GO :0016301 : kinase activity and also this GO :0016772 : transferase activity, this GO :0004713 : protein tyrosine kinase activity, this GO :0004714 : transmembrane receptor protein tyrosine kinase activity, this GO :0004871 : signal transducer activity, this GO :0004992 : platelet activating factor receptor activity, this GO :0005017 : platelet-derived growth factor-activated receptor activity, this GO :0005019 : platelet-derived growth factor beta-receptor activity, this GO :0005102 : receptor binding, this GO :0005161 : platelet-derived growth factor receptor binding, this GO :0005515 : protein binding, this GO :0005524 : ATP binding, this GO :0016301 : kinase activity, this GO :0016772 : transferase activity, this GO :0019901 : protein kinase binding, this GO :0038085 : vascular endothelial growth factor binding, this GO :0043548 : phosphatidylinositol 3-kinase binding, this GO :0048407 : platelet-derived growth factor binding, transferase activity, transferring phosphorus-containing groups, transferring phosphorus-containing groups and also this GO :0019901 : protein kinase binding and also this GO :0038085 : vascular endothelial growth factor binding and also this GO :0043548 : phosphatidylinositol 3-kinase binding and also this GO :0048407 : platelet-derived growth factor binding, transferring phosphorus-containing groups and molecular function this GO :0018108 and peptidyl-tyrosine phosphorylation and biological process this GO :0019901 and protein kinase binding and molecular function this GO :0030325 and adrenal gland development and biological process this GO :0030335 and positive regulation of cell migration and biological process this GO :0031226 and intrinsic component of plasma membrane and cellular component this GO :0032355 and response to estradiol and biological process this GO :0032516 and positive regulation of phosphoprotein phosphatase activity and biological process this GO :0032526 and response to retinoic acid and biological process this GO :0032956 and regulation of actin cytoskeleton organization and biological process this GO :0032967 and positive regulation of collagen biosynthetic process and biological process this GO :0033993 and response to lipid and biological process this GO :0034405 and response to fluid shear stress and biological process this GO :0035441 and cell migration involved in vasculogenesis and biological process this GO :0035556 and intracellular signal transduction and biological process this GO :0035789 and metanephric mesenchymal cell migration and biological process this GO :0035791 and platelet-derived growth factor receptor-beta signaling pathway and biological process this GO :0035793 and positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway and biological process this GO :0035909 and aorta morphogenesis and biological process this GO :0036120 and cellular response to platelet-derived growth factor stimulus and biological process this GO :0038085 and vascular endothelial growth factor binding and molecular function this GO :0038091 and positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway and biological process this GO :0038095 and Fc-epsilon receptor signaling pathway and biological process this GO :0042060 and wound healing and biological process this GO :0042542 and response to hydrogen peroxide and biological process this GO :0043066 and negative regulation of apoptotic process and biological process this GO :0043202 and lysosomal lumen and cellular component this GO :0043406 and positive regulation of MAP kinase activity and biological process this GO :0043548 and phosphatidylinositol 3-kinase binding and molecular function this GO :0043552 and positive regulation of phosphatidylinositol 3-kinase activity and biological process this GO :0043627 and response to estrogen and biological process this GO :0045087 and innate immune response and biological process this GO :0045840 and positive regulation of mitosis and biological process this GO :0046488 and phosphatidylinositol metabolic process and biological process this GO :0046777 and protein autophosphorylation and biological process this GO :0048008 and platelet-derived growth factor receptor signaling pathway and biological process this GO :0048011 and neurotrophin TRK receptor signaling pathway and biological process this GO :0048015 and phosphatidylinositol-mediated signaling and biological process this GO :0048407 and platelet-derived growth factor binding and molecular function this GO :0048661 and positive regulation of smooth muscle cell proliferation and biological process this GO :0048705 and skeletal system morphogenesis and biological process this GO :0048745 and smooth muscle tissue development and biological process this GO :0048839 and inner ear development and biological process this GO :0050730 and regulation of peptidyl-tyrosine phosphorylation and biological process this GO :0050921 and positive regulation of chemotaxis and biological process this GO :0055003 and cardiac myofibril assembly and biological process this GO :0055093 and response to hyperoxia and biological process this GO :0060326 and cell chemotaxis and biological process this GO :0060981 and cell migration involved in coronary angiogenesis and biological process this GO :0061298 and retina vasculature development in camera-type eye and biological process this GO :0070062 and extracellular vesicular exosome and cellular component this GO :0070374 and positive regulation of ERK1 and ERK2 cascade and biological process this GO :0071670 and smooth muscle cell chemotaxis and biological process this GO :0072075 and metanephric mesenchyme development and biological process this GO :0072262 and metanephric glomerular mesangial cell proliferation involved in metanephros development and biological process this GO :0072275 and metanephric glomerulus morphogenesis and biological process this GO :0072277 and metanephric glomerular capillary formation and biological process this GO :0072278 and metanephric comma-shaped body morphogenesis and biological process this GO :0072284 and metanephric S-shaped body morphogenesis and biological process this GO :0090280 and positive regulation of calcium ion import and biological process this GO :2000379 and positive regulation of reactive oxygen species metabolic process and biological process this GO :2000573 and positive regulation of DNA biosynthetic process and biological process, 74208 and IDBG-646273 and ENSBTAG00000002804 and 527165, platelet-derived growth factor receptor |
| Identity: |
8804 |
| Gene: |
PDGFRB |
More about : PDGFRB |
| Long gene name: |
platelet derived growth factor receptor beta |
| Synonyms gene: |
PDGFR |
| Synonyms gene name: |
beta polypeptide , platelet-derived growth factor receptor |
| Synonyms: |
JTK12 CD140b PDGFR1 |
| Locus: |
5q32 |
| Discovery year: |
2001-06-22 |
| GenBank acession: |
M21616 |
| Entrez gene record: |
5159 |
| RefSeq identity: |
NM_002609 |
| Classification: |
I-set domain containing CD molecules Immunoglobulin like domain containing Receptor Tyrosine Kinases |
| Havana BLAST/BLAT: |
OTTHUMG00000130053 |